Medium Chain Triglycerides (mcts) + Darunavir, Cobicistat
Darunavir, Cobicistat brand name: Prezcobix.
We found no known interaction between Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Darunavir, Cobicistat states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Darunavir, Cobicistat and Medium Chain Triglycerides (mcts) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Medium Chain Triglycerides (mcts) at all — not against Darunavir, Cobicistat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Medium Chain Triglycerides (mcts) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Darunavir, Cobicistat Products Have a Food Rule — Medium Chain Triglycerides (mcts) Should Not Break It
At least one FDA label for a product containing Darunavir, Cobicistat says to take it with food. If you take Medium Chain Triglycerides (mcts) on an empty stomach out of habit, keep them separate — and take Darunavir, Cobicistat with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Darunavir, Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended dosage: Adults and pediatric patients weighing at least 40 kg: One 800 mg/150 mg tablet taken once daily with food.
From the Dosage and Administration section of the FDA label we read for Darunavir, Cobicistat — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Darunavir, Cobicistat
This page covers Medium Chain Triglycerides (mcts) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Darunavir, Cobicistat page lists 145 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 102 moderate · 40 minor.
From our pharmacist’s overview on the Darunavir, Cobicistat page
“Prezcobix (darunavir with cobicistat) treats HIV, and it only works if it holds a steady blood level, so this list of 145 supplements deserves real care. Three carry a major rating and matter most: St.”
Reviewed by 2 · Jul 18, 2026
Where Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,157 of 1,452 supplements looked up here in the last 7 days
#855 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Medium Chain Triglycerides (mcts) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Medium Chain Triglycerides (mcts)
What is Medium Chain Triglycerides (mcts)?
- Energy and sports nutrition
- Weight management
- Ketogenic diets
- Brain and cognitive support
- Nutrition support in medical conditions
Medium chain triglycerides (MCTs) are fats from coconut or palm oil that the body absorbs and uses for energy quickly. They are widely used as an energy source, in ketogenic diets, and in some medical nutrition, but evidence for big benefits like weight loss is modest. They are generally well tolerated when taken in small, gradually increased amounts, but can cause stomach upset.
Fatty acids extracted from coconut or palm kernel oil · Oil, liquid, powder, capsules
An interaction check asks whether these two react with each other — it does not ask whether Medium Chain Triglycerides (mcts) is a good idea for someone in your situation. Here is what our Medium Chain Triglycerides (mcts) record says about it on its own.
Medium Chain Triglycerides (mcts): dosing
There is no single standardized dose of MCTs that fits everyone, and the right amount depends on why you are using it and how well you tolerate it.A practical approach is to start low and go slow: begin with a small amount, such as a teaspoon, and gradually increase over days or weeks to reduce stomach upset. Taking MCTs with food can also help.Always follow the directions on your specific product label, since concentrations vary between oils, powders, and capsules. If you are using MCTs as part of a medical diet, follow your doctor's or dietitian's instructions.
From our Medium Chain Triglycerides (mcts) monograph — the full record covers uses, side effects and every documented interaction.
About Darunavir and Cobicistat
What Is Darunavir and Cobicistat Used For?
Brand name: Prezcobix
Prezcobix and Prezcobix Ped are used to treat HIV-1 (human immunodeficiency virus type 1) infection. They are always used together with other antiretroviral (anti-HIV) medicines — never alone. Both products are approved for people who are new to HIV treatment (treatment-naïve) and for those who have taken HIV medicines before (treatment-experienced), as long as certain darunavir resistance mutations are not present.
Prezcobix tablets are approved for adults and pediatric patients weighing at least 40 kg. Prezcobix Ped tablets for oral suspension extend coverage to pediatric patients 3 years of age and older weighing at least 15 kg.
Other Drugs & Medium Chain Triglycerides (mcts)
Browse every other medication we’ve checked against Medium Chain Triglycerides (mcts) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Medium Chain Triglycerides (mcts) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Medium Chain Triglycerides (mcts) list.
Medium Chain Triglycerides (mcts) References
The 6 references that drive our Medium Chain Triglycerides (mcts) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24. DOI
- Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79. PubMed
- Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. PubMed
- St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. PubMed
- Jain A, Mochi TB, Braganza SD, Agrawal S, Shetty BK, Pachiyappan B. Lipemia retinalis in an infant treated for retinopathy of prematurity. J AAPOS 2017;21(3):254-57. PubMed
- Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat Together: Common Questions
Is it safe to take Medium Chain Triglycerides (mcts) with Darunavir, Cobicistat?
Do Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat have any of the same side effects?
Should I take Medium Chain Triglycerides (mcts) and Darunavir, Cobicistat at the same time of day?
Does Darunavir, Cobicistat interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.