Medium Chain Triglycerides (mcts) + Pregabalin
Pregabalin brand names: Lyrica, Lyrica CR.
We found no known interaction between Medium Chain Triglycerides (mcts) and Pregabalin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Medium Chain Triglycerides (mcts) and Pregabalin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pregabalin and Medium Chain Triglycerides (mcts) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Medium Chain Triglycerides (mcts) at all — not against Pregabalin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Medium Chain Triglycerides (mcts) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Pregabalin Is Prescribed For, and What Medium Chain Triglycerides (mcts) Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Pregabalin is a prescription medicine with approved uses on its FDA label. Medium Chain Triglycerides (mcts) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Pregabalin is prescribed for: Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury. Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.
Medium Chain Triglycerides (mcts) has been studied for:
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Diabetes studied, not established Medium Chain Triglycerides (mcts) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Medium Chain Triglycerides (mcts) for diabetes
Although there has been interest in using oral MCTs for diabetes, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pregabalin on your own; if you are taking Medium Chain Triglycerides (mcts) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Medium Chain Triglycerides (mcts) or Pregabalin
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Medium Chain Triglycerides (mcts) or Pregabalin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Lyrica And Flexeril Together? ›
- Can You Take Gabapentin And Codeine Together? ›
- What Can Cause A Gabapentin False-Positive On A Drug Test? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Pregabalin
This page covers Medium Chain Triglycerides (mcts) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pregabalin page lists 95 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 73 moderate · 15 minor.
From our pharmacist’s overview on the Pregabalin page
“Pregabalin (Lyrica) calms overactive nerves, which is how it eases nerve pain, seizures, and anxiety, and that calming action stacks with almost everything on this list. Of the 95 supplements and herbs, the large majority add their own sedation on top of pregabalin's, and a few can tip that into genuine danger, with deep sedation and s…”
Reviewed by 2 · Jul 18, 2026
Where Medium Chain Triglycerides (mcts) and Pregabalin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,005 of 1,452 supplements looked up here in the last 7 days
#40 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Medium Chain Triglycerides (mcts) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Medium Chain Triglycerides (mcts) and Pregabalin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Medium Chain Triglycerides (mcts)
What is Medium Chain Triglycerides (mcts)?
- Energy and sports nutrition
- Weight management
- Ketogenic diets
- Brain and cognitive support
- Nutrition support in medical conditions
Medium chain triglycerides (MCTs) are fats from coconut or palm oil that the body absorbs and uses for energy quickly. They are widely used as an energy source, in ketogenic diets, and in some medical nutrition, but evidence for big benefits like weight loss is modest. They are generally well tolerated when taken in small, gradually increased amounts, but can cause stomach upset.
Fatty acids extracted from coconut or palm kernel oil · Oil, liquid, powder, capsules
An interaction check asks whether these two react with each other — it does not ask whether Medium Chain Triglycerides (mcts) is a good idea for someone in your situation. Here is what our Medium Chain Triglycerides (mcts) record says about it on its own.
Medium Chain Triglycerides (mcts): dosing
There is no single standardized dose of MCTs that fits everyone, and the right amount depends on why you are using it and how well you tolerate it.A practical approach is to start low and go slow: begin with a small amount, such as a teaspoon, and gradually increase over days or weeks to reduce stomach upset. Taking MCTs with food can also help.Always follow the directions on your specific product label, since concentrations vary between oils, powders, and capsules. If you are using MCTs as part of a medical diet, follow your doctor's or dietitian's instructions.
From our Medium Chain Triglycerides (mcts) monograph — the full record covers uses, side effects and every documented interaction.
About Pregabalin
What Is Pregabalin Used For?
Brand names: Lyrica, Lyrica CR
Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury.
Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.
Most-Reported Side Effects for Pregabalin
From FAERS, the FDA’s public side-effect reporting system (270,557 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Medium Chain Triglycerides (mcts)
Browse every other medication we’ve checked against Medium Chain Triglycerides (mcts) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Medium Chain Triglycerides (mcts) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Medium Chain Triglycerides (mcts) list.
Medium Chain Triglycerides (mcts) References
The 6 references that drive our Medium Chain Triglycerides (mcts) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24. DOI
- Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79. PubMed
- Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. PubMed
- St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. PubMed
- Jain A, Mochi TB, Braganza SD, Agrawal S, Shetty BK, Pachiyappan B. Lipemia retinalis in an infant treated for retinopathy of prematurity. J AAPOS 2017;21(3):254-57. PubMed
- Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Medium Chain Triglycerides (mcts) and Pregabalin Together: Common Questions
Is it safe to take Medium Chain Triglycerides (mcts) with Pregabalin?
Do Medium Chain Triglycerides (mcts) and Pregabalin have any of the same side effects?
Are Medium Chain Triglycerides (mcts) and Pregabalin used for the same thing?
Does Pregabalin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.