Drug & supplement interaction

Medium Chain Triglycerides (mcts) + Propranolol

Propranolol brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, and others.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Medium Chain Triglycerides (mcts) and Propranolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Medium Chain Triglycerides (mcts) and Propranolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Propranolol and Medium Chain Triglycerides (mcts) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Medium Chain Triglycerides (mcts) at all — not against Propranolol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Medium Chain Triglycerides (mcts) safety at a glance

Medium Chain Trigl... overall Use caution Generally well tolerated in moderate amounts but can cause digestive upset, especially at higher doses.
Pregnancy Use caution Small amounts from food are fine, but supplement-level doses have not been well studied; check with your doctor.
Breastfeeding Use caution MCTs occur naturally in breast milk, but added supplement doses are not well studied; talk to your doctor first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Propranolol and Medium Chain Triglycerides (mcts)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Medium Chain Triglycerides (mcts) Itself Has Been Linked To

This is not an interaction — nothing below involves Propranolol. It is the side-effect record for Medium Chain Triglycerides (mcts) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Medium Chain Triglycerides (mcts), this list is the first place to look.

  • Heartburn / Mood changes or irritability / Bloating or gas / Stomach upset / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, MCTs can cause significant gastrointestinal upset. Diarrhea is the most commonly reported side effect. Other reported side effects include vomiting, irritability, nausea, reflux, abdominal discomfort, intestinal gas noises, and essential fatty acid deficiency. Taking MCTs with food can reduce these adverse effects.”

    Medium Chain Triglycerides (mcts) · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 11723. Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24. DOI
    2. 93737. Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. PubMed
    3. 93738. St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. PubMed
    4. 101967. Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163. PubMed
    5. 93731. Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79. PubMed
  • Weight gain Additional detail

    Recorded for Medium Chain Triglycerides (mcts) in the same Natural Medicines adverse-effect record shown under Heartburn / Mood changes or irritability / Bloating or gas / Stomach upset / Diarrhea / Vomiting / Nausea above.

Everything above comes from the Natural Medicines adverse-effect record for Medium Chain Triglycerides (mcts) — expand a row for the licensed statement it rests on. We haven’t matched Propranolol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Propranolol.

Everything else you take

See Every Supplement That Interacts With Propranolol

This page covers Medium Chain Triglycerides (mcts) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propranolol page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 194 moderate · 37 minor.

From our pharmacist’s overview on the Propranolol page

“Propranolol (Inderal) slows the heart and lowers blood pressure, which is exactly why its 236-ingredient interaction list deserves genuine care. Five entries rate major, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Propranolol interaction page

How much people look this up

Where Medium Chain Triglycerides (mcts) and Propranolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Medium Chain Triglycerides (mcts)
Steady interest

#1,001 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propranolol
Top 10

#8 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Medium Chain Triglycerides (mcts) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Medium Chain Triglycerides (mcts) and Propranolol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Medium Chain Triglycerides (mcts)

What is Medium Chain Triglycerides (mcts)?

  • Energy and sports nutrition
  • Weight management
  • Ketogenic diets
  • Brain and cognitive support
  • Nutrition support in medical conditions

Medium chain triglycerides (MCTs) are fats from coconut or palm oil that the body absorbs and uses for energy quickly. They are widely used as an energy source, in ketogenic diets, and in some medical nutrition, but evidence for big benefits like weight loss is modest. They are generally well tolerated when taken in small, gradually increased amounts, but can cause stomach upset.

Fatty acids extracted from coconut or palm kernel oil · Oil, liquid, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Medium Chain Triglycerides (mcts) is a good idea for someone in your situation. Here is what our Medium Chain Triglycerides (mcts) record says about it on its own.

Medium Chain Triglycerides (mcts): dosing

There is no single standardized dose of MCTs that fits everyone, and the right amount depends on why you are using it and how well you tolerate it.A practical approach is to start low and go slow: begin with a small amount, such as a teaspoon, and gradually increase over days or weeks to reduce stomach upset. Taking MCTs with food can also help.Always follow the directions on your specific product label, since concentrations vary between oils, powders, and capsules. If you are using MCTs as part of a medical diet, follow your doctor's or dietitian's instructions.

From our Medium Chain Triglycerides (mcts) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Medium Chain Triglycerides (mcts) monograph & all interactions
Medication

About Propranolol (Cardiovascular)

What Is Propranolol (Cardiovascular) Used For?

Brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, Half-Inderal LA, Bedranol SR, Half Beta Prograne, Beta Prograne, Lopranol LA, Slo-Pro, InnoPran XL

This intravenous (IV) form of propranolol is used in hospital or clinical settings to treat dangerous heart rhythm problems. It is generally reserved for life-threatening arrhythmias (abnormal heart rhythms) or those that occur during anesthesia.

Specific conditions it treats include fast heart rates coming from the upper chambers of the heart (supraventricular tachycardia), certain arrhythmias caused by digitalis toxicity, dangerous ventricular rhythms that haven't responded to other treatments, and fast heart rates caused by excess adrenaline-like substances during surgery.

See full Propranolol (Cardiovascular) drug information
Keep checking

Other Drugs & Medium Chain Triglycerides (mcts)

Browse every other medication we’ve checked against Medium Chain Triglycerides (mcts) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Medium Chain Triglycerides (mcts) References

The 6 references that drive our Medium Chain Triglycerides (mcts) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24. DOI
  2. Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79. PubMed
  3. Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. PubMed
  4. St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. PubMed
  5. Jain A, Mochi TB, Braganza SD, Agrawal S, Shetty BK, Pachiyappan B. Lipemia retinalis in an infant treated for retinopathy of prematurity. J AAPOS 2017;21(3):254-57. PubMed
  6. Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Medium Chain Triglycerides (mcts) and Propranolol Together: Common Questions

Is it safe to take Medium Chain Triglycerides (mcts) with Propranolol?
We do not list a known interaction between Medium Chain Triglycerides (mcts) and Propranolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Propranolol interact with any supplements?
Yes. Propranolol has documented interactions with 236 supplements in our database — Medium Chain Triglycerides (mcts) is not one of them. The Propranolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.