Drug & supplement interaction

Miracle Fruit + Belladonna Alkaloids, Phenobarbital

Belladonna Alkaloids, Phenobarbital brand names: Barbidonna, Donnatal.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Miracle Fruit and Belladonna Alkaloids, Phenobarbital in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Miracle Fruit and Belladonna Alkaloids, Phenobarbital

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Belladonna Alkaloids, Phenobarbital and Miracle Fruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Miracle Fruit safety at a glance

Miracle Fruit overall Use caution Generally well tolerated as a food, but long-term and high-dose safety has not been well studied.
Pregnancy Use caution There is not enough reliable safety data, so it is best to avoid concentrated supplements and use caution.
Breastfeeding Use caution There is not enough reliable safety data, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Belladonna Alkaloids, Phenobarbital and Miracle Fruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Belladonna Alkaloids, Phenobarbital

Interactions in our licensed database are recorded against drug classes, not just single drug names. Belladonna Alkaloids, Phenobarbital is filed under 12 classifications — including atropine, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2c9 (cyp2c9) inducers. Miracle Fruit has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Belladonna Alkaloids, Phenobarbital’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Miracle Fruit Does Interact With Other Medications

Miracle Fruit has 86 moderate known drug interactions in our database — Belladonna Alkaloids, Phenobarbital isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Belladonna Alkaloids, Phenobarbital)
Taking anything else?

Check Another of Your Medications Against Miracle Fruit

Covers the 2,830 medications we’ve checked against Miracle Fruit. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Belladonna Alkaloids, Phenobarbital

This page covers Miracle Fruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Belladonna Alkaloids, Phenobarbital page lists 167 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 11 major · 134 moderate · 22 minor.

Open the Belladonna Alkaloids, Phenobarbital interaction page

How much people look this up

Where Miracle Fruit and Belladonna Alkaloids, Phenobarbital Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Miracle Fruit
Top half

#625 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Belladonna Alkaloids, Phenobarbital
Steady interest

#2,194 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Miracle Fruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Miracle Fruit and Belladonna Alkaloids, Phenobarbital records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Miracle Fruit

What is Miracle Fruit?

Miracle Fruit
  • Making sour foods taste sweet
  • Sugar substitute or sweetness enhancer
  • Reducing added sugar intake
  • Improving taste during chemotherapy
  • Novelty 'flavor tripping' experiences

Miracle fruit contains a protein called miraculin that temporarily makes sour and acidic foods taste sweet for up to about an hour. It is generally considered safe as a food when used occasionally, but high-quality research on any health benefits is limited. If you are pregnant, breastfeeding, or have a medical condition, check with your pharmacist or doctor first.

Synsepalum dulcificum · Sapotaceae · Fruit (berry) · Fresh berries, freeze-dried tablets, freeze-dried powder, frozen pulp

An interaction check asks whether these two react with each other — it does not ask whether Miracle Fruit is a good idea for someone in your situation. Here is what our Miracle Fruit record says about it on its own.

Miracle Fruit: dosing

There is no official or standardized medical dose for miracle fruit. Products are usually sold as a single fresh berry, a freeze-dried tablet, or a small amount of powder meant for one taste-changing session.The best approach is to follow the directions on the product label and not use more than recommended.

From our Miracle Fruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Miracle Fruit monograph & all interactions
Keep checking

Other Drugs & Miracle Fruit

Browse every other medication we’ve checked against Miracle Fruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Miracle Fruit page.

No interaction 2,743 drugs checked — show the list

We also checked Miracle Fruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Miracle Fruit list.

See the full Miracle Fruit interactions page
See every supplement checked against Belladonna Alkaloids, Phenobarbital, ranked by severity
Evidence & sources

Miracle Fruit References

The 1 references that drive our Miracle Fruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Obafemi TO, Olaleye MT, Akinmoladun AC. Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Miracle Fruit and Belladonna Alkaloids, Phenobarbital Together: Common Questions

Is it safe to take Miracle Fruit with Belladonna Alkaloids, Phenobarbital?
We do not list a known interaction between Miracle Fruit and Belladonna Alkaloids, Phenobarbital. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Miracle Fruit and Belladonna Alkaloids, Phenobarbital combination checked?
Interactions in our licensed database are recorded against drug classes. Belladonna Alkaloids, Phenobarbital is filed under 12 classifications, and Miracle Fruit has documented interactions with 1 drug class — none of Belladonna Alkaloids, Phenobarbital's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Miracle Fruit interact with any other medications?
Yes. Miracle Fruit has 86 documented drug interactions in our database — Belladonna Alkaloids, Phenobarbital is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Belladonna Alkaloids, Phenobarbital interact with any supplements?
Yes. Belladonna Alkaloids, Phenobarbital has documented interactions with 167 supplements in our database — Miracle Fruit is not one of them. The Belladonna Alkaloids, Phenobarbital interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Miracle Fruit monograph Uses, safety profile, and every drug interaction in one place Belladonna Alkaloids, Phenobarbital supplement interactions Every supplement checked against Belladonna Alkaloids, Phenobarbital, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Belladonna Alkaloids, Phenobarbital and Miracle Fruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.