Medication interaction hub

What Supplements Interact with Belladonna Alkaloids, Phenobarbital?

Belladonna Alkaloids, Phenobarbital brand names: Barbidonna, Donnatal. Every interaction below applies to the brands too.

167 Interactions 11 Major 134 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belladonna Alkaloids, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belladonna Alkaloids, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

167 supplements and herbal ingredients have interactions with Belladonna Alkaloids, Phenobarbital on file in the HelloPharmacist interaction database — 11 rated major, 134 moderate, and 22 minor. The most serious involve Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal.

Our assessment: with 11 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Belladonna Alkaloids, Phenobarbital.

Major 11 Moderate 134 Minor 22 No known interaction 1,285

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Belladonna Alkaloids, Phenobarbital: Top Interactions at a Glance

The Belladonna Alkaloids, Phenobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 167 interacting ingredients — plus 1,285 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Belladonna Alkaloids, Phenobarbital Combinations Today

The Belladonna Alkaloids, Phenobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Choline + Belladonna Alkaloids, Phenobarbitali

Theoretically, choline might decrease the effects of atropine in the brain.

Read the full interaction Moderate Likelihood Possible Bacopa + Belladonna Alkaloids, Phenobarbitali

Theoretically, concurrent use might decrease the effectiveness of both agents.

Read the full interaction Minor Likelihood Possible Alpha-gpc + Belladonna Alkaloids, Phenobarbitali

Theoretically, alpha-GPC might decrease the effects of scopolamine.

Read the full interaction Moderate Likelihood Possible Sceletium + Belladonna Alkaloids, Phenobarbitali

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Read the full interaction Moderate Likelihood Probable Folic Acid + Belladonna Alkaloids, Phenobarbitali

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.

Read the full interaction Major Likelihood Likely Beer + Belladonna Alkaloids, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Belladonna Alkaloids, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 167 with a Belladonna Alkaloids, Phenobarbital interaction on file and 1,285 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belladonna Alkaloids, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Choline with Belladonna Alkaloids, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, choline might decrease the effects of atropine in the brain.

Full Choline + Belladonna Alkaloids, Phenobarbital answer

Can you take Bacopa with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might decrease the effectiveness of both agents.

Full Bacopa + Belladonna Alkaloids, Phenobarbital answer

Can you take Alpha-gpc with Belladonna Alkaloids, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, alpha-GPC might decrease the effects of scopolamine.

Full Alpha-gpc + Belladonna Alkaloids, Phenobarbital answer

Can you take Sceletium with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Belladonna Alkaloids, Phenobarbital answer

Can you take Folic Acid with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.

Full Folic Acid + Belladonna Alkaloids, Phenobarbital answer

Can you take Gotu Kola with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Belladonna Alkaloids, Phenobarbital answer

Can you take Gravel Root with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Belladonna Alkaloids, Phenobarbital answer

Can you take Green Tea with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Green Tea + Belladonna Alkaloids, Phenobarbital answer

Can you take Griffonia Simplicifolia with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Belladonna Alkaloids, Phenobarbital answer

Can you take Groundsel with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Belladonna Alkaloids, Phenobarbital answer

Can you take Guar Gum with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Belladonna Alkaloids, Phenobarbital answer

Can you take Guarana with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Guarana + Belladonna Alkaloids, Phenobarbital answer

Can you take Guarumo with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Belladonna Alkaloids, Phenobarbital answer

Can you take Gum Arabic with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Belladonna Alkaloids, Phenobarbital answer

Can you take Hemp Agrimony with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Full Hemp Agrimony + Belladonna Alkaloids, Phenobarbital answer

Can you take Hesperidin with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with CNS depressants may cause additive sedative effects.

Full Hesperidin + Belladonna Alkaloids, Phenobarbital answer

Can you take Hops with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Belladonna Alkaloids, Phenobarbital answer

Can you take Horny Goat Weed with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.

Full Horny Goat Weed + Belladonna Alkaloids, Phenobarbital answer

Can you take Hound's Tongue with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers can increase the toxicity of the pyrrolizidine alkaloid (PA) constituents of hound's tongue.

Full Hound's Tongue + Belladonna Alkaloids, Phenobarbital answer

Can you take Huperzine A with Belladonna Alkaloids, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, huperzine A might decrease the effects of anticholinergic drugs.

Full Huperzine A + Belladonna Alkaloids, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belladonna Alkaloids, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belladonna Alkaloids, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belladonna Alkaloids, Phenobarbital sits in 12 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Scopolamine (Transderm Scop) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Belladonna Alkaloids, Phenobarbital through this category.

Atropine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Belladonna Alkaloids, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Belladonna Alkaloids, Phenobarbital through this category.

Related: does Belladonna Alkaloids, Phenobarbital deplete any nutrients?

Belladonna Alkaloids, Phenobarbital has 14 reported nutrient associations in the research literature — see the Belladonna Alkaloids, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belladonna Alkaloids, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belladonna Alkaloids, Phenobarbital.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Belladonna Alkaloids, Phenobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Belladonna Alkaloids, Phenobarbital.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Belladonna Alkaloids, Phenobarbital & Supplements: Common Questions

What supplements interact with Belladonna Alkaloids, Phenobarbital?
More than you might expect — 167 in total, though they are far from equal: 11 are rated major, 134 moderate, and 22 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Belladonna Alkaloids, Phenobarbital supplement interactions are the most serious?
Focus on the major group: Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Belladonna Alkaloids, Phenobarbital?
Usually yes — most people on Belladonna Alkaloids, Phenobarbital can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Barbidonna have the same supplement interactions as Belladonna Alkaloids, Phenobarbital?
Yes — Barbidonna, Donnatal all contain Belladonna Alkaloids, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Belladonna Alkaloids, Phenobarbital deplete any vitamins or nutrients?
It might — Belladonna Alkaloids, Phenobarbital has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Belladonna Alkaloids, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Belladonna Alkaloids, Phenobarbital and my other medications?
This page covers Belladonna Alkaloids, Phenobarbital against supplements and herbal ingredients. Checking Belladonna Alkaloids, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.