Drug & supplement interaction

Miracle Fruit + Insulin Glulisine (rDNA)

Insulin Glulisine (rDNA) brand name: Apidra.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Miracle Fruit has a moderate interaction with Insulin Glulisine (rDNA). Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Miracle Fruit and Insulin Glulisine (rDNA)

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Glulisine (rDNA)

Insulin Glulisine (rDNA) falls under ANTIDIABETES DRUGS — the group Miracle Fruit interacts with.

Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia. Evidence from an animal model shows that miracle fruit leaf increases insulin production and lowers fasting blood glucose and HbA1c in rats with streptozotocin-induced diabetes. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Apidra (insulin glulisine) is a fast-acting insulin that already lowers your blood sugar. The concern is that miracle fruit leaf might nudge blood sugar down too, so stacking the two could push you a little lower than expected. That raises the odds of hypoglycemia, which can show up as shakiness, sweating, a racing heart, confusion, or feeling lightheaded.

I'll be honest about the evidence though: this comes only from a rat study using the leaf, not people, so it's largely theoretical. The miracle fruit berries most folks eat occasionally are unlikely to cause trouble. Still, since insulin leaves little room for error, mention it to your pharmacist or doctor before using concentrated leaf supplements, and keep an eye on your sugar readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Obafemi TO, Olaleye MT, Akinmoladun AC. Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Miracle Fruit Also Interacts With Other Medications

Miracle Fruit has 85 moderate known drug interactions in our database — the Insulin Glulisine (rDNA) one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Insulin Glulisine (rDNA))
Taking anything else?

Check Another of Your Medications Against Miracle Fruit

Covers the 2,830 medications we’ve checked against Miracle Fruit. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Glulisine (rDNA)

This page covers Miracle Fruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Glulisine (rDNA) page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Glulisine (rDNA) page

“Apidra (insulin glulisine) is a rapid mealtime insulin, and this list calls for real vigilance. All 239 ingredients on file affect blood sugar, most of the 208 moderate entries by adding their own glucose lowering to the insulin's and raising the chance of a serious low.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Glulisine (rDNA) interaction page

How much people look this up

Where Miracle Fruit and Insulin Glulisine (rDNA) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Miracle Fruit
Top half

#625 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Glulisine (rDNA)
Steady interest

#2,267 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Miracle Fruit

What is Miracle Fruit?

Miracle Fruit
  • Making sour foods taste sweet
  • Sugar substitute or sweetness enhancer
  • Reducing added sugar intake
  • Improving taste during chemotherapy
  • Novelty 'flavor tripping' experiences

Miracle fruit contains a protein called miraculin that temporarily makes sour and acidic foods taste sweet for up to about an hour. It is generally considered safe as a food when used occasionally, but high-quality research on any health benefits is limited. If you are pregnant, breastfeeding, or have a medical condition, check with your pharmacist or doctor first.

Read the full Miracle Fruit monograph & all interactions
Medication

About Insulin Glulisine (rDNA origin) Injection

What Is Insulin Glulisine (rDNA origin) Injection Used For?

Brand name: Apidra

Apidra and Apidra SoloStar are used to improve glycemic control (blood sugar management) in adult and pediatric patients with diabetes mellitus. This includes both type 1 and type 2 diabetes.

Because insulin glulisine works very quickly, it is typically used around mealtimes to control the rise in blood sugar that happens after eating. It is generally used alongside a longer-acting insulin as part of a complete diabetes regimen.

See full Insulin Glulisine (rDNA origin) Injection drug information
Keep checking

Other Drugs & Miracle Fruit

Browse every other medication we’ve checked against Miracle Fruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Miracle Fruit page.

No interaction 2,744 drugs checked — show the list

We also checked Miracle Fruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Miracle Fruit list.

See the full Miracle Fruit interactions page
See every supplement checked against Insulin Glulisine (rDNA), ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Miracle Fruit monograph › Uses, safety, and every drug interaction in one place Insulin Glulisine (rDNA) supplement interactions › Every supplement checked against Insulin Glulisine (rDNA), ranked by severity Insulin Glulisine (rDNA origin) Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Miracle Fruit and Insulin Glulisine (rDNA) Together: Common Questions

Can you take Miracle Fruit with Insulin Glulisine (rDNA)?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Miracle Fruit and Insulin Glulisine (rDNA) interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Glulisine (rDNA) and Miracle Fruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.