Medication interaction hub

What Supplements Interact with Insulin Glulisine (rDNA)?

Insulin Glulisine (rDNA) brand name: Apidra. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Glulisine (rDNA)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Glulisine (rDNA) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Apidra (insulin glulisine) is a rapid mealtime insulin, and this list calls for real vigilance. All 239 ingredients on file affect blood sugar, most of the 208 moderate entries by adding their own glucose lowering to the insulin's and raising the chance of a serious low. The one major-rated entry, Siberian cocklebur, has caused severe hypoglycemia in people soon after eating it and should not be combined with insulin at all.

Many of these are herbs sold specifically for blood sugar support, exactly what someone with diabetes might buy on purpose, and a few are as ordinary as beer, where alcohol can trigger a sudden drop. A smaller cluster, niacin among them, pushes glucose upward and can blunt a dose instead. Only 30 of the 239 rate minor, and with an insulin timed to each meal, a shift in either direction can undo a carefully calculated dose.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin Glulisine (rDNA): Top Interactions at a Glance

The Insulin Glulisine (rDNA) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin Glulisine (rDNA) Combinations Today

The Insulin Glulisine (rDNA) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Turkey Tail Mushroom + Insulin Glulisine (rDNA)i

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Black Mulberry + Insulin Glulisine (rDNA)i

Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible White Mulberry + Insulin Glulisine (rDNA)i

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Miracle Fruit + Insulin Glulisine (rDNA)i

Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Insulin Glulisine (rDNA)i

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Moderate Likelihood Probable American Ginseng + Insulin Glulisine (rDNA)i

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Glulisine (rDNA)

All 1,452 ingredients in our database, ranked by severity — 239 with a Insulin Glulisine (rDNA) interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Glulisine (rDNA)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turkey Tail Mushroom with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Insulin Glulisine (rDNA) answer

Can you take Black Mulberry with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Mulberry + Insulin Glulisine (rDNA) answer

Can you take White Mulberry with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Insulin Glulisine (rDNA) answer

Can you take Miracle Fruit with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.

Full Miracle Fruit + Insulin Glulisine (rDNA) answer

Can you take Krill Oil with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Krill Oil + Insulin Glulisine (rDNA) answer

Can you take L-arginine with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.

Full L-arginine + Insulin Glulisine (rDNA) answer

Can you take L-cysteine with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Full L-cysteine + Insulin Glulisine (rDNA) answer

Can you take Lion's Mane Mushroom with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.

Full Lion's Mane Mushroom + Insulin Glulisine (rDNA) answer

Can you take Lotus with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Lotus + Insulin Glulisine (rDNA) answer

Can you take Lychee with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Lychee + Insulin Glulisine (rDNA) answer

Can you take Madagascar Periwinkle with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.

Full Madagascar Periwinkle + Insulin Glulisine (rDNA) answer

Can you take Maitake Mushroom with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Maitake Mushroom + Insulin Glulisine (rDNA) answer

Can you take Manchurian Thorn with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that saponins isolated from Manchurian thorn can lower plasma glucose levels.

Full Manchurian Thorn + Insulin Glulisine (rDNA) answer

Can you take Maritime Pine with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maritime Pine + Insulin Glulisine (rDNA) answer

Can you take Melatonin with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Melatonin + Insulin Glulisine (rDNA) answer

Can you take Milk Thistle with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Insulin Glulisine (rDNA) answer

Can you take Myrrh with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Myrrh + Insulin Glulisine (rDNA) answer

Can you take Neem with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Neem + Insulin Glulisine (rDNA) answer

Can you take Oats with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Full Oats + Insulin Glulisine (rDNA) answer

Can you take Octacosanol with Insulin Glulisine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.

Full Octacosanol + Insulin Glulisine (rDNA) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Glulisine (rDNA) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Glulisine (rDNA), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Glulisine (rDNA) sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Glulisine (rDNA) through this category.

About Insulin Glulisine (rDNA)

Insulin glulisine is a rapid-acting insulin analog used to improve blood sugar control in adults and children with diabetes mellitus.

Generic name: Insulin Glulisine (rDNA)  ·  Brand name: Apidra.

See the full Insulin Glulisine (rDNA origin) Injection drug information

Related: does Insulin Glulisine (rDNA) deplete any nutrients?

Insulin Glulisine (rDNA) has 1 reported nutrient association in the research literature — see the Insulin Glulisine (rDNA) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Glulisine (rDNA)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Glulisine (rDNA).

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Pharmacist Counseling Corner

Insulin Glulisine (rDNA) & Supplements: Common Questions

What supplements interact with Insulin Glulisine (rDNA)?
More than you might expect — 239 in total, though they are far from equal: 1 are rated major, 208 moderate, and 30 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Insulin Glulisine (rDNA) supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Glulisine (rDNA)?
Usually yes — most people on Insulin Glulisine (rDNA) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Apidra have the same supplement interactions as Insulin Glulisine (rDNA)?
Yes — Apidra all contain Insulin Glulisine (rDNA), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Glulisine (rDNA) deplete any vitamins or nutrients?
It might — Insulin Glulisine (rDNA) has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Glulisine (rDNA) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Glulisine (rDNA) and my other medications?
This page covers Insulin Glulisine (rDNA) against supplements and herbal ingredients. Checking Insulin Glulisine (rDNA) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Insulin Glulisine (rDNA origin) Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.