Drug & supplement interaction

Bacillus Coagulans + Insulin Glulisine (rDNA)

Insulin Glulisine (rDNA) brand name: Apidra.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Bacillus Coagulans and Insulin Glulisine (rDNA) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bacillus Coagulans and Insulin Glulisine (rDNA)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Insulin Glulisine (rDNA) and Bacillus Coagulans in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bacillus Coagulans safety at a glance

Bacillus Coagulans overall Use caution Generally well tolerated in healthy adults, but evidence and product quality vary.

Pregnancy Use caution Not enough reliable safety data; talk to your doctor before using.

Breastfeeding Use caution Limited safety information; check with your doctor or pharmacist first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Insulin Glulisine (rDNA) and Bacillus Coagulans? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Insulin Glulisine (rDNA)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Insulin Glulisine (rDNA) is filed under a single classification — antidiabetes drugs. Bacillus Coagulans has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Insulin Glulisine (rDNA)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bacillus Coagulans Does Interact With Other Medications

Bacillus Coagulans has 182 moderate known drug interactions in our database — Insulin Glulisine (rDNA) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Insulin Glulisine (rDNA))

Taking anything else?

Check Another of Your Medications Against Bacillus Coagulans

Covers the 2,830 medications we’ve checked against Bacillus Coagulans. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bacillus Coagulans and Insulin Glulisine (rDNA) May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

A higher chance of infection Worth acting on Additional detail
Bacillus Coagulans
“Since many probiotic preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Bacteremia and sepsis have been reported in patients with indwelling or central venous catheters or patients who are severely ill and/or immunocompromised, including preterm infants, that were using probiotic products.”

Bacillus Coagulans · Natural Medicines adverse-effect record, reported in prematurity.
6 sources cited

4380. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed

8561. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed

13008. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.

13070. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed

90298. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed

102416. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
Insulin Glulisine (rDNA)

Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Glulisine (rDNA). Read the label on DailyMed ›

Effects for Insulin Glulisine (rDNA) come from the ADVERSE REACTIONS section of its FDA label; effects for Bacillus Coagulans come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Insulin Glulisine (rDNA) Is Prescribed For, and What Bacillus Coagulans Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Insulin Glulisine (rDNA) is a prescription medicine with approved uses on its FDA label. Bacillus Coagulans is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Insulin Glulisine (rDNA) is prescribed for: Apidra and Apidra SoloStar are used to improve glycemic control (blood sugar management) in adult and pediatric patients with diabetes mellitus. This includes both type 1 and type 2 diabetes. Because insulin glulisine works very quickly, it is typically used around mealtimes to control the rise in blood sugar that happens after eating. It is generally used alongside a longer-acting insulin as part of a complete diabetes regimen.

Bacillus Coagulans has been studied for:

Diabetes studied, not established Bacillus Coagulans has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Bacillus Coagulans for diabetes

Oral Bacillus coagulans has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Insulin Glulisine (rDNA) on your own; if you are taking Bacillus Coagulans for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Insulin Glulisine (rDNA)

This page covers Bacillus Coagulans only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Glulisine (rDNA) page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Glulisine (rDNA) page

“Apidra (insulin glulisine) is a rapid mealtime insulin, and this list calls for real vigilance. All 239 ingredients on file affect blood sugar, most of the 208 moderate entries by adding their own glucose lowering to the insulin's and raising the chance of a serious low.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Glulisine (rDNA) interaction page

One more smart check

Taking Bacillus Coagulans as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,895 real supplement products containing Bacillus Coagulans, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bacillus Coagulans. Even though Bacillus Coagulans itself has no known interaction with Insulin Glulisine (rDNA), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bacillus Coagulans and Insulin Glulisine (rDNA) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bacillus Coagulans

Top 25%

#160 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Insulin Glulisine (rDNA)

Steady interest

#1,810 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bacillus Coagulans reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bacillus Coagulans and Insulin Glulisine (rDNA) records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Bacillus Coagulans

What is Bacillus Coagulans?

Constipation
Irritable bowel syndrome (IBS)
Diarrhea
General digestive health
Immune support
Bloating and gas

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The evidence is promising but still limited, and quality and strains vary between products. It is generally well tolerated in healthy people, but people with weak immune systems and those who are pregnant or breastfeeding should talk to a doctor first.

Weizmannia coagulans (formerly Bacillus coagulans) · Bacillaceae · Live spore-forming bacteria (probiotic cells/spores) · Capsules, tablets, chewables, powders, and added to some foods and drinks

An interaction check asks whether these two react with each other — it does not ask whether Bacillus Coagulans is a good idea for someone in your situation. Here is what our Bacillus Coagulans record says about it on its own.

Bacillus Coagulans: dosing

There is no single official dose of Bacillus coagulans. Probiotic amounts are usually measured in CFU (colony-forming units), and different products use different strains and strengths.The best approach is to follow the dose on the product label and not exceed it unless directed by a healthcare professional. If you notice gas or bloating at first, starting with a lower amount and increasing slowly may help.

From our Bacillus Coagulans monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bacillus Coagulans monograph & all interactions

Medication

About Insulin Glulisine (rDNA origin) Injection

What Is Insulin Glulisine (rDNA origin) Injection Used For?

Brand name: Apidra

Apidra and Apidra SoloStar are used to improve glycemic control (blood sugar management) in adult and pediatric patients with diabetes mellitus. This includes both type 1 and type 2 diabetes.

Because insulin glulisine works very quickly, it is typically used around mealtimes to control the rise in blood sugar that happens after eating. It is generally used alongside a longer-acting insulin as part of a complete diabetes regimen.

See full Insulin Glulisine (rDNA origin) Injection drug information

Keep checking

Other Drugs & Bacillus Coagulans

Browse every other medication we’ve checked against Bacillus Coagulans — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

182Moderate

0Minor

2,647No known interaction

182 Moderate 2,647 No interaction

Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Bacillus Coagulans page.

No interaction 2,647 drugs checked — show the list

We also checked Bacillus Coagulans against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Bacillus Coagulans list.

See the full Bacillus Coagulans interactions page

See every supplement checked against Insulin Glulisine (rDNA), ranked by severity

Evidence & sources

Bacillus Coagulans References

The 20 references that drive our Bacillus Coagulans monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Insulin Glulisine (rDNA) Is Linked to Lower Levels of One Nutrient

Natural Medicines records Insulin Glulisine (rDNA) as a medicine that can lower these. This is not an interaction with Bacillus Coagulans — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

COENZYME Q10›

Read the full Insulin Glulisine (rDNA) nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Bacillus Coagulans and Insulin Glulisine (rDNA) Together: Common Questions

Is it safe to take Bacillus Coagulans with Insulin Glulisine (rDNA)?

We do not list a known interaction between Bacillus Coagulans and Insulin Glulisine (rDNA). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Bacillus Coagulans and Insulin Glulisine (rDNA) have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Bacillus Coagulans and Insulin Glulisine (rDNA) used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Bacillus Coagulans in each. That is a conversation for your prescriber, especially if Insulin Glulisine (rDNA) is being adjusted to a target.

How was the Bacillus Coagulans and Insulin Glulisine (rDNA) combination checked?

Interactions in our licensed database are recorded against drug classes. Insulin Glulisine (rDNA) is filed under 1 classification, and Bacillus Coagulans has documented interactions with 1 drug class — none of Insulin Glulisine (rDNA)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Bacillus Coagulans interact with any other medications?

Yes. Bacillus Coagulans has 182 documented drug interactions in our database — Insulin Glulisine (rDNA) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Insulin Glulisine (rDNA) interact with any supplements?

Yes. Insulin Glulisine (rDNA) has documented interactions with 239 supplements in our database — Bacillus Coagulans is not one of them. The Insulin Glulisine (rDNA) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bacillus Coagulans monograph Uses, safety profile, and every drug interaction in one place Insulin Glulisine (rDNA origin) Injection drug information The full plain-English guide to this medication Insulin Glulisine (rDNA) supplement interactions Every supplement checked against Insulin Glulisine (rDNA), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Insulin Glulisine (rDNA) and Bacillus Coagulans?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.