Drug & supplement interaction

Myrtle + Atazanavir, Cobicistat

Atazanavir, Cobicistat brand name: Evotaz.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Myrtle and Atazanavir, Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atazanavir, Cobicistat states a food rule worth keeping to.

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Interaction report

Myrtle and Atazanavir, Cobicistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atazanavir, Cobicistat and Myrtle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Myrtle at all — not against Atazanavir, Cobicistat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Myrtle safety at a glance

Myrtle overall Use caution Likely safe in small amounts as food or tea, but concentrated extracts and oils need caution.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atazanavir, Cobicistat and Myrtle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Myrtle Itself Has Been Linked To

This is not an interaction — nothing below involves Atazanavir, Cobicistat. It is the side-effect record for Myrtle on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Myrtle, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Orally, consumption of very large amounts of undiluted myrtle leaf oil might lead to respiratory failure and collapse (18).

    Topically, facial contact with myrtle oil preparations may cause glottal or bronchial spasm, asthma-like attacks, or respiratory failure in infants and children (18).”

    Myrtle · Natural Medicines adverse-effect record, reported in asthma.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Dry skin Additional detail

    “Topically, myrtle leaf extract has been reported to cause dry skin.”

    Myrtle · Natural Medicines adverse-effect record, reported in dry skin.

    1 source cited
    1. 106777. Salmanian M, Shirbeigi L, Hashem-Dabaghian F, et al. The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study. J Pharmacopuncture 2020;23(4):220-229.
  • Low blood pressure Additional detail

    “Orally, very large amounts of undiluted myrtle leaf oil might lead to low blood pressure and circulatory disorders due to the cineole constituent (18).”

    Myrtle · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Constipation Additional detail

    “Orally, myrtle berry extract has been reported to cause constipation in infants and young children.”

    Myrtle · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 106781. Paknejad MS, Eftekhari K, Rahimi R, Vigeh M, Naghizadeh A, Karimi M. Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double-blind randomized clinical trial. Phytother Res 2021;35(11):6369-6376.

Everything above comes from the Natural Medicines adverse-effect record for Myrtle — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Atazanavir, Cobicistat’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Atazanavir, Cobicistat column appears here.

Special populations

Myrtle in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Atazanavir, Cobicistat Products Have a Food Rule — Myrtle Should Not Break It

At least one FDA label for a product containing Atazanavir, Cobicistat says to take it with food. If you take Myrtle on an empty stomach out of habit, keep them separate — and take Atazanavir, Cobicistat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atazanavir, Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

(2.1) • Recommended dosage: One tablet once daily, taken orally with food in adults and pediatric patients weighing at least 35 kg.

From the Dosage and Administration section of the FDA label we read for Atazanavir, Cobicistat — where that label names a specific product, the instruction is that product's. See the Atazanavir, Cobicistat drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atazanavir, Cobicistat

This page covers Myrtle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atazanavir, Cobicistat page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 107 moderate · 42 minor.

From our pharmacist’s overview on the Atazanavir, Cobicistat page

“Evotaz (atazanavir with cobicistat) treats HIV, and its effectiveness depends on steady blood levels, so I read this list of 152 supplements and herbs carefully rather than casually. Only three carry a major rating, but those three deserve your attention first: St.”

Reviewed by 2 · Jul 18, 2026

Open the Atazanavir, Cobicistat interaction page

One more smart check

Taking Myrtle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 33 real supplement products containing Myrtle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Myrtle. Even though Myrtle itself has no known interaction with Atazanavir, Cobicistat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Myrtle and Atazanavir, Cobicistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Myrtle
Steady interest

#1,217 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atazanavir, Cobicistat
Top half

#1,358 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Myrtle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Myrtle and Atazanavir, Cobicistat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Myrtle

What is Myrtle?

  • Coughs and respiratory congestion
  • Digestive upset
  • Antimicrobial and wound care
  • Skin conditions
  • Urinary complaints

Myrtle (Myrtus communis) is a Mediterranean shrub used traditionally for respiratory, digestive, and skin complaints. Modern research is mostly limited to laboratory and small studies, so its benefits in people are not well proven. Use cautiously, follow product labels, and talk to your pharmacist or doctor first—especially since the essential oil should never be swallowed.

Myrtus communis · Myrtaceae · Leaves, berries, flowers, and essential oil · Tea, capsules, extracts, essential oil, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Myrtle is a good idea for someone in your situation. Here is what our Myrtle record says about it on its own.

Myrtle: dosing

There is no well-established standard dose for myrtle. Amounts used in traditional practice and studies vary widely depending on the form—tea, extract, capsule, or oil.Because products differ in strength and quality, the safest approach is to follow the directions on the product label and not exceed them.

From our Myrtle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Myrtle monograph & all interactions
Medication

About Atazanavir and Cobicistat

What Is Atazanavir and Cobicistat Used For?

Brand name: Evotaz

Evotaz (atazanavir/cobicistat) is used to treat HIV-1 infection. It must always be taken together with other antiretroviral medicines — it is not a complete regimen on its own. It is approved for adults and for pediatric patients who weigh at least 35 kg.

In patients who have been on HIV treatment before (treatment-experienced), how well Evotaz works depends on how much resistance to protease inhibitors the virus has already developed. Your prescriber will review this before starting you on Evotaz.

See full Atazanavir and Cobicistat drug information
Keep checking

Other Drugs & Myrtle

Browse every other medication we’ve checked against Myrtle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Myrtle References

The 3 references that drive our Myrtle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Salmanian M, Shirbeigi L, Hashem-Dabaghian F, et al. The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study. J Pharmacopuncture 2020;23(4):220-229.
  3. Paknejad MS, Eftekhari K, Rahimi R, Vigeh M, Naghizadeh A, Karimi M. Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double-blind randomized clinical trial. Phytother Res 2021;35(11):6369-6376.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Myrtle and Atazanavir, Cobicistat Together: Common Questions

Is it safe to take Myrtle with Atazanavir, Cobicistat?
We do not list a known interaction between Myrtle and Atazanavir, Cobicistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Myrtle and Atazanavir, Cobicistat at the same time of day?
At least one FDA label for a product containing Atazanavir, Cobicistat says to take it with food. If you take Myrtle on an empty stomach out of habit, keep them separate and take Atazanavir, Cobicistat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atazanavir, Cobicistat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Atazanavir, Cobicistat interact with any supplements?
Yes. Atazanavir, Cobicistat has documented interactions with 152 supplements in our database — Myrtle is not one of them. The Atazanavir, Cobicistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Atazanavir, Cobicistat and Myrtle?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.