Medication interaction hub

What Supplements Interact with Atazanavir, Cobicistat?

Atazanavir, Cobicistat brand name: Evotaz. Every interaction below applies to the brands too.

152 Interactions 3 Major 107 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atazanavir, Cobicistat? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atazanavir, Cobicistat against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Evotaz (atazanavir with cobicistat) treats HIV, and its effectiveness depends on steady blood levels, so I read this list of 152 supplements and herbs carefully rather than casually. Only three carry a major rating, but those three deserve your attention first: St. John's wort can speed the drug's clearance enough to risk treatment failure and viral resistance, grapefruit pushes levels the opposite direction, and activated charcoal can simply soak up a dose before it absorbs.

A smaller cluster of fibers and charcoals can blunt absorption of anything taken by mouth, so those need real distance from each dose. Most of the other entries, 107 rated moderate and 42 minor, trace back to one liver enzyme, CYP3A4, which this combination both relies on and deliberately blocks. That is why so many herbs can nudge atazanavir levels up or down, and with an HIV regimen, drifting levels are the actual danger.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 107 Minor 42 No known interaction 1,300

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Atazanavir, Cobicistat: Top Interactions at a Glance

The Atazanavir, Cobicistat supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 152 interacting ingredients — plus 1,300 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Atazanavir, Cobicistat Combinations Today

The Atazanavir, Cobicistat + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Caffeine + Atazanavir, Cobicistati

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Minor Likelihood Probable Zinc + Atazanavir, Cobicistati

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.

Read the full interaction Moderate Likelihood Possible Peppermint + Atazanavir, Cobicistati

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Black Tea + Atazanavir, Cobicistati

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Minor Likelihood Possible Guarana + Atazanavir, Cobicistati

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Calamus + Atazanavir, Cobicistati

Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Atazanavir, Cobicistat

All 1,452 ingredients in our database, ranked by severity — 152 with a Atazanavir, Cobicistat interaction on file and 1,300 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atazanavir, Cobicistat?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Caffeine with Atazanavir, Cobicistat?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Atazanavir, Cobicistat answer

Can you take Zinc with Atazanavir, Cobicistat?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.

Full Zinc + Atazanavir, Cobicistat answer

Can you take Peppermint with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Atazanavir, Cobicistat answer

Can you take Black Tea with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Black Tea + Atazanavir, Cobicistat answer

Can you take Guarana with Atazanavir, Cobicistat?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Guarana + Atazanavir, Cobicistat answer

Can you take Glucomannan with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Atazanavir, Cobicistat answer

Can you take Guggul with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Atazanavir, Cobicistat answer

Can you take Schisandra with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Atazanavir, Cobicistat answer

Can you take Tree Turmeric with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Atazanavir, Cobicistat answer

Can you take Acacia Rigidula with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Atazanavir, Cobicistat answer

Can you take Adrafinil with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Full Adrafinil + Atazanavir, Cobicistat answer

Can you take African Wild Potato with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Full African Wild Potato + Atazanavir, Cobicistat answer

Can you take American Elder with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Atazanavir, Cobicistat answer

Can you take Astaxanthin with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Atazanavir, Cobicistat answer

Can you take Ayahuasca with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Atazanavir, Cobicistat answer

Can you take Bacopa with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Atazanavir, Cobicistat answer

Can you take Beet with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Atazanavir, Cobicistat answer

Can you take Berberine with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Atazanavir, Cobicistat answer

Can you take Beta-methylphenethylamine (bmpea) with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Atazanavir, Cobicistat answer

Can you take Bishop's Weed with Atazanavir, Cobicistat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Atazanavir, Cobicistat answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atazanavir, Cobicistat is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atazanavir, Cobicistat, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atazanavir, Cobicistat sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Atazanavir (Reyataz) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

Protease Inhibitors (Pis) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Atazanavir, Cobicistat through this category.

About Atazanavir, Cobicistat

Atazanavir and cobicistat is a two-drug combination used alongside other antiretroviral medicines to treat HIV-1 infection in adults and children weighing at least 35 kg.

Generic name: Atazanavir, Cobicistat  ·  Brand name: Evotaz.

See the full Atazanavir and Cobicistat drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atazanavir, Cobicistat

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atazanavir, Cobicistat.

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Pharmacist Counseling Corner

Atazanavir, Cobicistat & Supplements: Common Questions

What supplements interact with Atazanavir, Cobicistat?
Our database currently documents 152 ingredients with a known Atazanavir, Cobicistat interaction (3 major, 107 moderate, 42 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 152. The highest-ranked right now: Grapefruit, St. John's Wort, Activated Charcoal.
Which Atazanavir, Cobicistat supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, St. John's Wort and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Atazanavir, Cobicistat?
Plenty of supplements coexist fine with Atazanavir, Cobicistat; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Evotaz have the same supplement interactions as Atazanavir, Cobicistat?
Yes — Evotaz all contain Atazanavir, Cobicistat, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Atazanavir, Cobicistat and my other medications?
This page covers Atazanavir, Cobicistat against supplements and herbal ingredients. Checking Atazanavir, Cobicistat against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Atazanavir and Cobicistat drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.