Drug & supplement interaction

Nattokinase + Obinutuzumab

Obinutuzumab brand name: Gazyva.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Nattokinase and Obinutuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Obinutuzumab states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Nattokinase and Obinutuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Obinutuzumab and Nattokinase in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nattokinase safety at a glance

Nattokinase overall Use caution Generally tolerated short-term, but its blood-thinning effect means caution for people with bleeding risk.

Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.

Breastfeeding Avoid Safety is unknown while breastfeeding, so avoid it to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Obinutuzumab and Nattokinase? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Nattokinase Does Interact With Other Medications

Nattokinase has 289 moderate known drug interactions in our database — Obinutuzumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Obinutuzumab)

Taking anything else?

Check Another of Your Medications Against Nattokinase

Covers the 2,830 medications we’ve checked against Nattokinase. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Nattokinase and Obinutuzumab May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

An allergic reaction Worth acting on Additional detail
Nattokinase
“Orally, nattokinase can cause hypersensitivity reactions, including anaphylaxis, in individuals sensitive to natto. A case series examining hypersensitivity reactions to natto shows that the causative allergen can be either nattokinase or polygamma glutamic acid (PGA), both of which are found in the sticky substance surrounding natto soybeans.”

Nattokinase · Natural Medicines adverse-effect record, reported in dermatitis.
2 sources cited

109552. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed

111253. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.
Obinutuzumab

Listed in the ADVERSE REACTIONS section of the FDA label for Obinutuzumab. Read the label on DailyMed ›

Reported for Nattokinase but not commonly for Obinutuzumab: bleeding or bruising, an irregular heartbeat, a stroke or mini-stroke and a severe allergic reaction.

Effects for Obinutuzumab come from the ADVERSE REACTIONS section of its FDA label; effects for Nattokinase come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Obinutuzumab Products Have a Food Rule — Nattokinase Should Not Break It

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach. Most supplements — Nattokinase included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Obinutuzumab on its own and move Nattokinase to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Obinutuzumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

650–1,000 mg acetaminophen At least 30 minutes before GAZYVA infusion.

From the Dosage and Administration section of the FDA label we read for Obinutuzumab — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Obinutuzumab Is Prescribed For, and What Nattokinase Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Obinutuzumab is a prescription medicine with approved uses on its FDA label. Nattokinase is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Obinutuzumab is prescribed for: Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy. Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

Nattokinase has been studied for:

Cancer studied, not established Nattokinase has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Nattokinase for cancer

Although there has been interest in using oral nattokinase for cancer, there is insufficient reliable information about the clinical effects of nattokinase for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Obinutuzumab on your own; if you are taking Nattokinase for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Nattokinase or Obinutuzumab

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Nattokinase or Obinutuzumab, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Nattokinase as Part of a Dietary Supplement Product? Check It for Interactions

We hold 509 real supplement products containing Nattokinase, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nattokinase. Even though Nattokinase itself has no known interaction with Obinutuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nattokinase and Obinutuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nattokinase

Top 25%

#249 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Obinutuzumab

Steady interest

#1,955 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nattokinase reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nattokinase and Obinutuzumab records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Nattokinase

What is Nattokinase?

Heart and circulatory health
Blood clot prevention
High blood pressure
Improving blood flow
Cholesterol support

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulation, but the evidence is limited and more research is needed. Because it can affect clotting, talk to your pharmacist or doctor before trying it, especially if you take medicines or have a bleeding risk.

Enzyme extracted from natto (fermented soybeans) · Capsules, tablets, softgels

An interaction check asks whether these two react with each other — it does not ask whether Nattokinase is a good idea for someone in your situation. Here is what our Nattokinase record says about it on its own.

Nattokinase: dosing

There is no official or standardized dose of nattokinase. Products are often measured in "fibrinolytic units" (FU), and the amount varies a lot from brand to brand.Because of this, the best approach is to follow the directions on the product label and not take more than recommended.

From our Nattokinase monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nattokinase monograph & all interactions

Medication

About Obinutuzumab Injection

What Is Obinutuzumab Injection Used For?

Brand name: Gazyva

Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy.

Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

See full Obinutuzumab Injection drug information

Keep checking

Other Drugs & Nattokinase

Browse every other medication we’ve checked against Nattokinase — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

289Moderate

0Minor

2,540No known interaction

289 Moderate 2,540 No interaction

Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Nattokinase page.

No interaction 2,540 drugs checked — show the list

We also checked Nattokinase against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Nattokinase list.

See the full Nattokinase interactions page

See every supplement checked against Obinutuzumab, ranked by severity

Evidence & sources

Nattokinase References

The 9 references that drive our Nattokinase monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
<p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nattokinase and Obinutuzumab Together: Common Questions

Is it safe to take Nattokinase with Obinutuzumab?

We do not list a known interaction between Nattokinase and Obinutuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Nattokinase and Obinutuzumab have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Nattokinase and Obinutuzumab at the same time of day?

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Obinutuzumab on its own and move Nattokinase to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Are Nattokinase and Obinutuzumab used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Nattokinase in each. That is a conversation for your prescriber, especially if Obinutuzumab is being adjusted to a target.

Does Nattokinase interact with any other medications?

Yes. Nattokinase has 289 documented drug interactions in our database — Obinutuzumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nattokinase monograph Uses, safety profile, and every drug interaction in one place Obinutuzumab Injection drug information The full plain-English guide to this medication Obinutuzumab supplement interactions Every supplement checked against Obinutuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Obinutuzumab and Nattokinase?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.