Drug & supplement interaction

Nutmeg + Fruquintinib

Fruquintinib brand name: Fruzaqla.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Nutmeg and Fruquintinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Nutmeg and Fruquintinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fruquintinib and Nutmeg in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nutmeg safety at a glance

Nutmeg overall Use caution Safe as a food spice, but larger doses can be toxic and cause serious poisoning.

Pregnancy Likely Safe When used orally and appropriately in amounts commonly found in foods. Read the full pregnancy detail

Breastfeeding Likely Safe When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg when used... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fruquintinib and Nutmeg? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Fruquintinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fruquintinib is filed under 3 classifications — hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Nutmeg has documented interactions with 5 drug classes — the most serious being anticholinergic drugs (moderate), cholinergic drugs (moderate) and cns depressants (moderate) — and none of Fruquintinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Nutmeg Does Interact With Other Medications

Nutmeg has 528 moderate known drug interactions in our database — Fruquintinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 528 No known interaction 2,302 (incl. Fruquintinib)

Taking anything else?

Check Another of Your Medications Against Nutmeg

Covers the 2,830 medications we’ve checked against Nutmeg. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Nutmeg and Fruquintinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Tiredness Additional detail
Nutmeg
“Orally, headache, dizziness, and drowsiness were reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis. Adverse effects associated with high intake of nutmeg have included confusion, dizziness, drowsiness, hallucinations, headache, incoherent speech, hot and cold sensations, sensations of limb loss, convulsions, and coma.”

Nutmeg · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed

19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed

19299. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed

19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed

19487. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed

19489. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
Fruquintinib

Listed in the ADVERSE REACTIONS section of the FDA label for Fruquintinib. Read the label on DailyMed ›
Diarrhea / Vomiting Additional detail
Nutmeg
“Orally, nausea was reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis. Vomiting was reported in a case of a 19-year-old female using high doses of nutmeg with a history of lysergic acid diethylamide (LSD) and cannabis use. Burning epigastric pain, gastroenteritis, diarrhea, nausea, and increased thirst have been reported in other cases of intentional or unintentional nutmeg overdose.”

Nutmeg · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed

19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed

19293. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed

19299. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed

19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed

19489. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
Fruquintinib

Listed in the ADVERSE REACTIONS section of the FDA label for Fruquintinib. Read the label on DailyMed ›

Reported for Nutmeg but not commonly for Fruquintinib: thoughts of self-harm, increased thirst, confusion and hallucinations.

Effects for Fruquintinib come from the ADVERSE REACTIONS section of its FDA label; effects for Nutmeg come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Nutmeg in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally and appropriately in amounts commonly found in foods.

Pregnancy Possibly Unsafe

When used orally in medicinal amounts. Nutmeg might have abortifacient activity, and its safrole content might be mutagenic.

Lactation Likely Safe

When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg when used in larger, medicinal amounts during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Fruquintinib

This page covers Nutmeg only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fruquintinib page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Fruquintinib page

“Fruquintinib (Fruzaqla) is an oral targeted therapy for advanced colorectal cancer, which means keeping its blood level steady is part of what makes it work, and I would treat this supplement list with genuine care. Of the 168 ingredients on file, the large majority interact through CYP3A4, the liver enzyme that clears the drug, so the…”

Reviewed by 2 · Jul 18, 2026

Open the Fruquintinib interaction page

One more smart check

Taking Nutmeg as Part of a Dietary Supplement Product? Check It for Interactions

We hold 182 real supplement products containing Nutmeg, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nutmeg. Even though Nutmeg itself has no known interaction with Fruquintinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nutmeg and Fruquintinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nutmeg

Top half

#653 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Fruquintinib

Top 25%

#537 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nutmeg reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Nutmeg and Fruquintinib records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Nutmeg

What is Nutmeg?

Digestive upset
Diarrhea
Sleep and relaxation
Pain and inflammation
Flavoring spice

Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little solid human research to support its medicinal use. In normal cooking amounts it is generally safe, but larger "medicinal" doses can cause serious poisoning, so it should never be taken in high amounts.

Myristica fragrans · Myristicaceae · Seed (nutmeg), seed covering (mace), and essential oil · Whole or ground spice, powder, capsules, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Nutmeg is a good idea for someone in your situation. Here is what our Nutmeg record says about it on its own.

Nutmeg: dosing

There is no well-established medicinal dose for nutmeg, and no standardized supplement dose has been proven safe and effective for any health condition. As a spice, the small amounts used in cooking are considered safe.Because the line between a flavoring amount and a toxic amount is not very wide, you should not take large doses of nutmeg for health purposes.

From our Nutmeg monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nutmeg monograph & all interactions

Medication

About Fruquintinib

What Is Fruquintinib Used For?

Brand name: Fruzaqla

Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is intended for patients who have already been treated with several prior chemotherapy regimens and other targeted therapies.

Specifically, Fruzaqla is for patients previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Most-Reported Side Effects for Fruquintinib

From FAERS, the FDA’s public side-effect reporting system (3,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 470 reports

Colorectal cancer metastatic 388 reports

Colon cancer 371 reports

Diarrhea 275 reports

Blood pressure increased 269 reports

See full Fruquintinib drug information

Keep checking

Other Drugs & Nutmeg

Browse every other medication we’ve checked against Nutmeg — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

528Moderate

0Minor

2,301No known interaction

528 Moderate 2,301 No interaction

Moderate

528 interactions

Showing 60 of 528 moderate interactions — see all 528 on the Nutmeg page.

No interaction 2,301 drugs checked — show the list

We also checked Nutmeg against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,301 medications checked with no known interaction — see the full Nutmeg list.

See the full Nutmeg interactions page

See every supplement checked against Fruquintinib, ranked by severity

Evidence & sources

Nutmeg References

The 29 references that drive our Nutmeg monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5. PubMed
Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed
Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7. PubMed
Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
Sherry CJ, Ray LE, Herron RE. The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans). J Ethnopharmacol. 1982;6(1):61-6.
Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007;21(12):1142-5. PubMed
Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24. PubMed
Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed
Futrell JM, Rietschel RL. Spice allergy evaluated by results of patch tests. Cutis. 1993;52(5):288-90.
van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T. Contact allergy to spices. Contact Dermatitis. 1990;22(5):267-72. PubMed
Beattie RT. Nutmeg as a psychoactive agent. Br J Addict Alcohol Other Drugs. 1968;63(1):105-9. PubMed
Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46. PubMed
Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996. PubMed
Atherton RR. The 'Nutmeg Challenge': a dangerous social media trend. Arch Dis Child. 2020:archdischild-2020-319407. PubMed
Medagoda K. A family with nutmeg poisoning due to a home-made 'Covid treatment syrup'. Natl Med J India 2022;35(3):187. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nutmeg and Fruquintinib Together: Common Questions

Is it safe to take Nutmeg with Fruquintinib?

We do not list a known interaction between Nutmeg and Fruquintinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Nutmeg and Fruquintinib have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Nutmeg and Fruquintinib combination checked?

Interactions in our licensed database are recorded against drug classes. Fruquintinib is filed under 3 classifications, and Nutmeg has documented interactions with 5 drug classes — none of Fruquintinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Nutmeg interact with any other medications?

Yes. Nutmeg has 528 documented drug interactions in our database — Fruquintinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Fruquintinib interact with any supplements?

Yes. Fruquintinib has documented interactions with 168 supplements in our database — Nutmeg is not one of them. The Fruquintinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nutmeg monograph Uses, safety profile, and every drug interaction in one place Fruquintinib drug information The full plain-English guide to this medication Fruquintinib supplement interactions Every supplement checked against Fruquintinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 29 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fruquintinib and Nutmeg?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.