Drug & supplement interaction

Oak Moss + Carbidopa

Carbidopa brand name: Lodosyn.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Oak Moss and Carbidopa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Oak Moss and Carbidopa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Carbidopa and Oak Moss in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Oak Moss at all — not against Carbidopa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Oak Moss safety at a glance

Oak Moss overall Use caution Oak moss is a recognized skin allergen and is not well studied as an oral supplement.
Pregnancy Possibly Unsafe When used orally. The constituent thujone shows evidence of uterine stimulant activity. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. The constituent thujone shows evidence of uterine stimulant activity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Carbidopa and Oak Moss? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Oak Moss and Carbidopa May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Oak Moss

    “Orally, large amounts or long-term use of thujone-containing products, such as oak moss, may cause convulsions, restlessness, tremors, and vertigo (12).”

    Oak Moss · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Oak Moss

    “Topically, use of oak moss may cause contact sensitivity and allergic reactions in people with lichen and moss allergy. In patch testing, very late reactions have occurred, some as late as 27 days after application. Usnic acid, a constituent of oak moss, also can cause allergic contact dermatitis with respiratory symptoms.”

    Oak Moss · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 4023. Dahlquist I, Fregert S. Contact allergy to atranorin in lichens and perfumes. Contact Dermatitis 1980;6:111-9. PubMed
    2. 4033. Goncalo S. Contact sensitivity to lichens and compositae in Frullania dermatitis. Contact Dermatitis 1987;16:84-6. PubMed
    3. 4034. Goncalo S, Cabral F, Goncalo M. Contact sensitivity to oak moss. Contact Dermatitis 1988;19:355-7. PubMed
    4. 4039. Thune P, Solberg Y, McFadden N, et al. Perfume allergy due to oak moss and other lichens. Contact Dermatitis 1982;8:396-400. PubMed
    5. 108403. Schubert S, Schnuch A, Bauer A, et al. Very late reactions in the patch test with fragrance mix I and oak moss absolute (Evernia prunastri, INCI): Data of the Information Network of Departments of Dermatology (IVDK). Contact Dermatitis 2022;86(1):54-57.
    6. 11720. Ingolfsdottir K. Usnic acid. Phytochemistry 2002;61:729-36.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

  • Weight loss / Stomach pain / Tiredness / Nausea Additional detail

    Oak Moss

    “Orally, usnic acid, a constituent of oak moss, has been associated with reports of hepatotoxicity. From July to December 2000 there were at least seven cases of acute hepatotoxicity in patients taking LipoKinetix, a product containing usnic acid as sodium usniate.”

    Oak Moss · Natural Medicines adverse-effect record, reported in fatigue.

    6 sources cited
    1. 7091. Favreau JT, Ryu Ml, Braunstein G, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 2002;136:590-5. PubMed
    2. 81595. Durazo, F. A., Lassman, C., Han, S. H., Saab, S., Lee, N. P., Kawano, M., Saggi, B., Gordon, S., Farmer, D. G., Yersiz, H., Goldstein, R. L., Ghobrial, M., and Busuttil, R. W. Fulminant liver failure due to usnic acid for weight loss. Am.J Gastroenterol. PubMed
    3. 81600. Neff, G. W., Reddy, K. R., Durazo, F. A., Meyer, D., Marrero, R., and Kaplowitz, N. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004;41(6):1062-1064. PubMed
    4. 81607. Hsu, L. M., Huang, Y. S., Chang, F. Y., and Lee, S. D. 'Fat burner' herb, usnic Acid, induced acute hepatitis in a family. J Gastroenterol.Hepatol. 2005;20(7):1138-1139. PubMed
    5. 81612. Arneborn, P., Jansson, A., and Bottiger, Y. [Acute hepatitis in a woman after intake of slimming pills bought via Internet]. Lakartidningen 7-11-2005;102(28-29):2071-2072.
    6. 81619. Sanchez, W., Maple, J. T., Burgart, L. J., and Kamath, P. S. Severe hepatotoxicity associated with use of a dietary supplement containing usnic acid. Mayo Clin Proc 2006;81(4):541-544. PubMed

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

  • Anxiety or restlessness / Dizziness reported in 5.4% of FDA reports for Carbidopa Additional detail

    Oak Moss

    Recorded for Oak Moss in the same Natural Medicines adverse-effect record shown under Seizures above.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Oak Moss

    Recorded for Oak Moss in the same Natural Medicines adverse-effect record shown under Seizures above.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

  • Vomiting Additional detail

    Oak Moss

    “Orally, large amounts or long-term use of thujone-containing products may cause vomiting (12).”

    Oak Moss · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

Reported for Oak Moss but not commonly for Carbidopa: yellowing of the skin or eyes, liver problems and kidney problems.

Effects for Carbidopa come from the ADVERSE REACTIONS section of its FDA label; effects for Oak Moss come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 52,609 voluntary FDA FAERS reports for Carbidopa that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Oak Moss in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. The constituent thujone shows evidence of uterine stimulant activity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Carbidopa

This page covers Oak Moss only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carbidopa page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Magnesium (major), 5-htp (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 2 major · 10 moderate · 9 minor.

From our pharmacist’s overview on the Carbidopa page

“Carbidopa (Lodosyn) keeps levodopa working in Parkinson's disease, so anything that blocks its absorption can cost real motor control, and two of the 21 supplements on this list do exactly that at a level rated major. Magnesium is the one that surprises people: in a human study it cut carbidopa absorption by 81 percent and levodopa's b…”

Reviewed by 2 · Jul 18, 2026

Open the Carbidopa interaction page

How much people look this up

Where Oak Moss and Carbidopa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oak Moss
Steady interest

#1,061 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carbidopa
Top half

#1,030 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Oak Moss reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Oak Moss and Carbidopa records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Oak Moss

What is Oak Moss?

Oak Moss
  • Perfume base note and scent fixative
  • Aromatherapy and fragrance
  • Traditional antimicrobial use
  • Soaps and cosmetics fragrance

Oak moss is a lichen that grows on oak and other trees and is best known as a perfume ingredient prized for its earthy, woody scent. There is very little human evidence to support taking it for any health condition, and it is a well-known skin allergen, so it is mainly used externally in fragrances rather than as a dietary supplement.

Evernia prunastri · Parmeliaceae · Whole lichen (thallus) and its extract/absolute · Essential oil, absolute, extract, fragrance ingredient; occasionally tinctures

An interaction check asks whether these two react with each other — it does not ask whether Oak Moss is a good idea for someone in your situation. Here is what our Oak Moss record says about it on its own.

Oak Moss: dosing

There is no established safe or effective oral dose for oak moss. It is not a standard dietary supplement, and reliable dosing information from human studies does not exist.If you come across an oak moss product, follow the directions on the label and do not exceed them. Given the lack of safety data, oral use is generally not recommended.

From our Oak Moss monograph — the full record covers uses, side effects and every documented interaction.

Read the full Oak Moss monograph & all interactions
Medication

About Carbidopa

What Is Carbidopa Used For?

Brand name: Lodosyn

Carbidopa tablets — sold under the brand name Lodosyn and as generic carbidopa — are used together with levodopa or carbidopa-levodopa to manage symptoms of Parkinson's disease, postencephalitic parkinsonism, and symptomatic parkinsonism that can result from carbon monoxide or manganese poisoning. Carbidopa is never used alone; it always works as a partner to levodopa-based therapy.

Lodosyn is specifically used when a patient taking carbidopa-levodopa isn't getting enough daily carbidopa from that combination, or when a patient needs the two drugs individually titrated (adjusted) rather than taken as a fixed combination. Adding carbidopa helps reduce the nausea and vomiting that levodopa often causes and allows lower doses of levodopa to be used.

Most-Reported Side Effects for Carbidopa

From FAERS, the FDA’s public side-effect reporting system (52,609 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 4,954 reports
Hallucination 4,554 reports
Tremor 3,533 reports
Dyskinesia 3,174 reports
Dizziness 2,837 reports
See full Carbidopa drug information
Keep checking

Other Drugs & Oak Moss

Browse every other medication we’ve checked against Oak Moss — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Oak Moss against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Oak Moss list.

See the full Oak Moss interactions page
See every supplement checked against Carbidopa, ranked by severity
Evidence & sources

Oak Moss References

The 16 references that drive our Oak Moss monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Dahlquist I, Fregert S. Contact allergy to atranorin in lichens and perfumes. Contact Dermatitis 1980;6:111-9. PubMed
  4. Goncalo S. Contact sensitivity to lichens and compositae in Frullania dermatitis. Contact Dermatitis 1987;16:84-6. PubMed
  5. Goncalo S, Cabral F, Goncalo M. Contact sensitivity to oak moss. Contact Dermatitis 1988;19:355-7. PubMed
  6. Thune P, Solberg Y, McFadden N, et al. Perfume allergy due to oak moss and other lichens. Contact Dermatitis 1982;8:396-400. PubMed
  7. Favreau JT, Ryu Ml, Braunstein G, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 2002;136:590-5. PubMed
  8. Ingolfsdottir K. Usnic acid. Phytochemistry 2002;61:729-36.
  9. Mitchell, J. C. Allergy to lichens. Allergic contact dermatitis from usnic acid produced by lichenized fungi. Arch Dermatol 1965;92(2):142-146.
  10. Durazo, F. A., Lassman, C., Han, S. H., Saab, S., Lee, N. P., Kawano, M., Saggi, B., Gordon, S., Farmer, D. G., Yersiz, H., Goldstein, R. L., Ghobrial, M., and Busuttil, R. W. Fulminant liver failure due to usnic acid for weight loss. Am.J Gastroenterol. PubMed
  11. Neff, G. W., Reddy, K. R., Durazo, F. A., Meyer, D., Marrero, R., and Kaplowitz, N. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004;41(6):1062-1064. PubMed
  12. Hsu, L. M., Huang, Y. S., Chang, F. Y., and Lee, S. D. 'Fat burner' herb, usnic Acid, induced acute hepatitis in a family. J Gastroenterol.Hepatol. 2005;20(7):1138-1139. PubMed
  13. Arneborn, P., Jansson, A., and Bottiger, Y. [Acute hepatitis in a woman after intake of slimming pills bought via Internet]. Lakartidningen 7-11-2005;102(28-29):2071-2072.
  14. Sanchez, W., Maple, J. T., Burgart, L. J., and Kamath, P. S. Severe hepatotoxicity associated with use of a dietary supplement containing usnic acid. Mayo Clin Proc 2006;81(4):541-544. PubMed
  15. Rafanelli, S., Bacchilega, R., Stanganelli, I., and Rafanelli, A. Contact dermatitis from usnic acid in vaginal ovules. Contact Dermatitis 1995;33(4):271-272. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Oak Moss and Carbidopa Together: Common Questions

Is it safe to take Oak Moss with Carbidopa?
We do not list a known interaction between Oak Moss and Carbidopa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Oak Moss and Carbidopa have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Carbidopa interact with any supplements?
Yes. Carbidopa has documented interactions with 21 supplements in our database — Oak Moss is not one of them. The Carbidopa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Oak Moss monograph Uses, safety profile, and every drug interaction in one place Carbidopa drug information The full plain-English guide to this medication Carbidopa supplement interactions Every supplement checked against Carbidopa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Carbidopa and Oak Moss?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.