Oregon Grape - Tricor (Fenofibrate) Interaction
Herbal: Oregon Grape
Also Known As: Mahonia aquifolium, Barberry, Berberis, Blue Barberry, Creeping Barberry, Holly Barberry, Holly Mahonia, Holly-Leaved Berberis, Mahonia, Mahonia Faux Houx, Mahonia à Feuilles de Houx, Mahonie, Mountain-Grape, Oregon Barberry, Oregon Grape-Holly, Scraperoot
Drug: Fenofibrate
Brand names:
Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, Lofibra, Triglide, Lipidil EZ
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
There were no interactions found between Fenofibrate and Oregon Grape. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Oregon Grape Overview
Oregon grape (Mahonia aquifolium) is a perennial shrub that is native to the Pacific Northwest region of the United States, including Oregon and Washington. It is also found in parts of Canada. The plant is a member of the barberry family (Berberidaceae) and is closely related to the holly plant.
Oregon grape is often grown as an ornamental plant due to its attractive foliage and colorful berries. It is also used medicinally and is believed to have astringent, tonic, and anti-inflammatory properties. The root of the plant is used to make a herbal extract that is used to treat a variety of ailments, including skin conditions, digestive problems, and respiratory conditions. Most of the positive evidence for a medicinal effect is with topical applications as some research has shown topical preparations may modestly decrease the severity of psoriasis. It is important to note that the berries of the plant can be somewhat bitter and may contain toxins, so they should be eaten in moderation.
Fenofibrate Overview
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Fenofibrate is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL (high-density lipoprotein; a type of fatty substance that decreases the risk of heart disease) in the blood. Build-up of cholesterol and fats along the walls of the arteries (a process known as atherosclerosis) decreases the blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. This increases the risk of heart disease, angina (chest pain), strokes, and heart attacks. Although fenofibrate decreases the levels of fatty substances in the blood, it has not been shown to decrease the risk of heart attacks or strokes. Fenofibrate is in a class of medications called antilipemic agents. It works by speeding the natural processes that remove cholesterol from the body.
Oregon Grape - More Interactions
Oregon Grape interacts with 1189 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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