Oregon Grape + Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan brand name: Byvalson.
Nebivolol Hydrochloride, Valsartan falls into 3 drug categories that Oregon Grape can interact with; the most serious is rated moderate. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full interaction reportOregon Grape and Nebivolol Hydrochloride, Valsartan
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Oregon Grape interacts with whole categories of medication. Nebivolol Hydrochloride, Valsartan falls into 3 of those categories, so it can interact with Oregon Grape in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 3Why this applies to Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan falls under ANTIHYPERTENSIVE DRUGS — the group Oregon Grape interacts with.
Animal research suggests that berberine, a constituent of Oregon grape, can have hypotensive effects. Also, an analysis of clinical evidence suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson is a two-in-one blood pressure pill: nebivolol (a beta-blocker) plus valsartan (an ARB). Both already work to lower your blood pressure. Oregon grape contains berberine, and in animal studies and some early human data berberine seems to nudge blood pressure down too. So the concern here is simple addition. Stack a blood-pressure-lowering supplement on top of two blood-pressure-lowering medicines, and your numbers could dip lower than intended.
If that happens, you might feel dizzy or lightheaded, especially when standing up, along with tiredness or a slower heartbeat. To be clear, this is mostly a theoretical concern based on lab and animal work, not strong human proof. Still, if you'd like to try Oregon grape, check with your pharmacist or doctor first, and keep an eye on your blood pressure readings.
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2D6 (CYP2D6).
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two medicines, and one of them, nebivolol, leans on a liver enzyme called CYP2D6 to be broken down and cleared from your body. Oregon grape contains berberine, which lab studies and some early human research suggest can slow that same enzyme down. If the enzyme works slower, nebivolol can build up a bit more than usual.
In practical terms, that could mean a stronger blood-pressure-lowering effect than you expect. Watch for things like feeling lightheaded or dizzy, unusual tiredness, or a slower heartbeat. The valsartan part isn't really affected here. Keep in mind this is mostly theoretical, with only modest evidence, so it isn't a guaranteed problem. Still, please check with your pharmacist or doctor before combining them rather than stopping anything on your own.
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
Preliminary clinical evidence suggests that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2C9 (CYP2C9).
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist: Byvalson combines nebivolol (a beta-blocker) with valsartan (a blood pressure pill). The valsartan part is partly handled by a liver enzyme called CYP2C9. Oregon grape contains berberine, which lab and early human studies suggest can slow that enzyme down. If the enzyme works slower, a little more valsartan could linger in your system, which may nudge your blood pressure lower than expected.
In real life that could show up as lightheadedness, dizziness when you stand up, or feeling unusually tired. To be fair, this is mostly theoretical and based on limited evidence, so it may never cause a problem. Still, I'd run it by your pharmacist or doctor before adding Oregon grape, especially the concentrated supplement form.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Oregon Grape Also Interacts With Other Medications
Oregon Grape has 1,217 moderate known drug interactions in our database — the Nebivolol Hydrochloride, Valsartan one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Oregon Grape
We haven’t checked that one against Oregon Grape yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Oregon Grape. Pick one to open its full report.
See Every Supplement That Interacts With Nebivolol Hydrochloride, Valsartan
This page covers Oregon Grape only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nebivolol Hydrochloride, Valsartan page lists 213 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
By severity: 5 major · 173 moderate · 35 minor.
From our pharmacist’s overview on the Nebivolol Hydrochloride, Valsartan page
“Nebivolol with valsartan (Byvalson) packs two blood pressure medicines into one pill, and I would treat this list with genuine care, especially its handful of serious entries. Most of the interactions tug on blood pressure itself, some deepening the drop until dizziness or fainting becomes a risk, others, tyramine among them, pushing p…”
Reviewed by 2 · Jul 18, 2026
Open the Nebivolol Hydrochloride, Valsartan interaction page
Taking Oregon Grape as Part of a Dietary Supplement Product? Check It for Interactions
We hold 740 real supplement products containing Oregon Grape, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oregon Grape. Your product may carry other ingredients that interact with Nebivolol Hydrochloride, Valsartan too, on top of Oregon Grape — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Oregon Grape and Nebivolol Hydrochloride, Valsartan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#228 of 1,452 supplements looked up here in the last 7 days
#299 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Oregon Grape
What is Oregon Grape?
- Psoriasis (topical)
- Eczema and other skin conditions
- Digestive upset
- Mild skin infections
- General 'detox' or tonic use
Oregon grape is a shrub whose root contains berberine and related compounds. The strongest (though still modest) evidence is for topical creams that may slightly ease psoriasis; evidence for other uses is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & Oregon Grape
Browse every other medication we’ve checked against Oregon Grape — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,217 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
Showing 60 of 1,217 moderate interactions — see all 1,217 on the Oregon Grape page.
No interaction 1,612 drugs checked — show the list
We also checked Oregon Grape against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Isotretinoin ›
- Docusate ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Levothyroxine, Liothyronine ›
- Bendamustine ›
- Azithromycin ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Ezetimibe ›
- Cyclopentolate ›
- Cephalexin ›
- Thyroid Hormone ›
- Roxithromycin ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Alginic Acid, Aluminum Hydroxide ›
- Mitomycin ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Magnesium Hydroxide (otc Drug) ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Flutemetamol F-18 ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Cefaclor ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Daptomycin ›
- Articaine, Epinephrine ›
- Peginterferon Alfa-2a, Ribavirin ›
- Acetaminophen, Butalbital ›
- Charcoal (otc Drug) ›
- Hydroxychloroquine ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Alpha-1 Proteinase Inhibitor ›
- Alendronate Sodium, Cholecalciferol ›
- Factor 7a ›
- Colistin, Neomycin, Hydrocortisone ›
- Hexobarbitone ›
- Bentoquatam ›
- Pegunigalsidase Alfa-iwxj ›
- Aminolevulinic Acid Hydrochloride ›
- Rosuvastatin Calcium, Ezetimibe ›
- Efgartigimod Alfa-fcab ›
- Birth Control Pills ›
- Droxidopa ›
- Alglucosidase Alpha ›
- Paracetamol ›
Showing the 60 most looked-up of 1,612 medications checked with no known interaction — see the full Oregon Grape list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Nebivolol Hydrochloride, Valsartan Is Linked to Lower Levels of One Nutrient
Natural Medicines records Nebivolol Hydrochloride, Valsartan as a medicine that can lower these. This is not an interaction with Oregon Grape — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Nebivolol Hydrochloride, Valsartan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Oregon Grape and Nebivolol Hydrochloride, Valsartan Together: Common Questions
Can you take Oregon Grape with Nebivolol Hydrochloride, Valsartan?
Why are there 3 interactions listed for Oregon Grape and Nebivolol Hydrochloride, Valsartan?
How serious is the Oregon Grape and Nebivolol Hydrochloride, Valsartan interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.