Drug & supplement interaction

Osha + Dalfampridine

Dalfampridine brand name: Ampyra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Osha and Dalfampridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Osha and Dalfampridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dalfampridine and Osha in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Osha at all — not against Dalfampridine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Osha safety at a glance

Osha overall Use caution Limited safety data exist, and wild osha can be confused with poisonous look-alike plants.
Pregnancy Likely Unsafe When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated. Read the full pregnancy detail
Breastfeeding Avoid No reliable safety data are available, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dalfampridine and Osha? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dalfampridine’s Own FDA Label Lists

This is not an interaction — none of it involves Osha. These are the most notable effects listed in the ADVERSE REACTIONS section of Dalfampridine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Unsteadiness Worth acting on mentioned in 22.3% of FDA reports for Dalfampridine
  • Confusion Worth acting on
  • Seizures Worth acting on
  • A severe allergic reaction Worth acting on
  • A higher chance of infection Worth acting on
  • Back pain
  • Numbness or tingling
  • Trouble sleeping
  • Stomach upset
  • Tiredness mentioned in 7.8% of FDA reports for Dalfampridine

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Dalfampridine. Read the label on DailyMed › Where a percentage is shown, it is the share of 71,315 voluntary FDA FAERS reports for Dalfampridine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Osha’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Osha side to compare — that is a limit of the record, not a statement that Osha has no side effects.

Special populations

Osha in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Dalfampridine

This page covers Osha only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dalfampridine page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Dalfampridine page

“Activated charcoal is the entry I would put in front of anyone taking dalfampridine (Ampyra) for walking difficulty in multiple sclerosis. It is the only major-rated interaction among the 23 on this page, because charcoal can adsorb medication in the gut and cut how much reaches the bloodstream, and an unreliable dose is a real problem…”

Reviewed by 2 · Jul 18, 2026

Open the Dalfampridine interaction page

One more smart check

Taking Osha as Part of a Dietary Supplement Product? Check It for Interactions

We hold 336 real supplement products containing Osha, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Osha. Even though Osha itself has no known interaction with Dalfampridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Osha and Dalfampridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Osha
Top half

#457 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dalfampridine
Steady interest

#1,886 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Osha reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Osha and Dalfampridine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Osha

What is Osha?

  • Cough and sore throat
  • Respiratory infections and colds
  • Immune support
  • Digestive upset
  • Bronchitis and congestion

Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats. Solid human research is lacking, so its benefits remain unproven, and it should be avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before trying it.

Ligusticum porteri · Apiaceae · Root · Tea, tincture, capsules, lozenges, chewed raw root

An interaction check asks whether these two react with each other — it does not ask whether Osha is a good idea for someone in your situation. Here is what our Osha record says about it on its own.

Osha: dosing

There is no established standard dose for osha. The right amount depends on the form (tea, tincture, capsule, or lozenge) and the product's strength.If you choose to use osha, follow the directions on the product label and do not exceed them.

From our Osha monograph — the full record covers uses, side effects and every documented interaction.

Read the full Osha monograph & all interactions
Medication

About Dalfampridine

What Is Dalfampridine Used For?

Brand name: Ampyra

Dalfampridine extended-release tablets — sold as Ampyra and as the generic dalfampridine — are used to improve walking in adults with multiple sclerosis (MS). In clinical studies, this benefit was shown by an increase in walking speed.

Most-Reported Side Effects for Dalfampridine

From FAERS, the FDA’s public side-effect reporting system (71,315 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Gait disturbance 10,977 reports
Fall 7,335 reports
Fatigue 5,527 reports
Balance disorder 4,900 reports
Multiple sclerosis relapse 4,774 reports
See full Dalfampridine drug information
Keep checking

Other Drugs & Osha

Browse every other medication we’ve checked against Osha — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Osha against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Osha list.

See the full Osha interactions page
See every supplement checked against Dalfampridine, ranked by severity
Evidence & sources

Osha References

The 2 references that drive our Osha monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Osha and Dalfampridine Together: Common Questions

Is it safe to take Osha with Dalfampridine?
We do not list a known interaction between Osha and Dalfampridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Dalfampridine interact with any supplements?
Yes. Dalfampridine has documented interactions with 23 supplements in our database — Osha is not one of them. The Dalfampridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Osha monograph Uses, safety profile, and every drug interaction in one place Dalfampridine drug information The full plain-English guide to this medication Dalfampridine supplement interactions Every supplement checked against Dalfampridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dalfampridine and Osha?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.