Drug & supplement interaction

Pantethine + Carfilzomib

Carfilzomib brand name: Kyprolis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Pantethine and Carfilzomib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pantethine and Carfilzomib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Carfilzomib and Pantethine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pantethine safety at a glance

Pantethine overall Use caution Generally well tolerated in studies, but long-term safety data are limited.
Pregnancy Use caution Not enough reliable safety data, so it is best to avoid unless your doctor advises otherwise.
Breastfeeding Use caution Safety during breastfeeding has not been well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Carfilzomib and Pantethine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Carfilzomib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Carfilzomib is filed under a single classification — hepatotoxic drugs. Pantethine has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Carfilzomib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pantethine Does Interact With Other Medications

Pantethine has 122 moderate known drug interactions in our database — Carfilzomib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Carfilzomib)
Taking anything else?

Check Another of Your Medications Against Pantethine

Covers the 2,830 medications we’ve checked against Pantethine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pantethine and Carfilzomib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Diarrhea / Vomiting / Nausea Additional detail

    Pantethine

    “The most common adverse effects to pantethine are mild gastrointestinal complaints such as nausea, vomiting, diarrhea, epigastric discomfort, bloating, and flatulence.”

    Pantethine · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 8315. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
    2. 8316. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
    3. 8862. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
    4. 67725. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
    5. 67748. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
    6. 67754. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.

    Carfilzomib

    Listed in the ADVERSE REACTIONS section of the FDA label for Carfilzomib. Read the label on DailyMed ›

  • Itching Additional detail

    Pantethine

    “Orally, mild pruritus has been reported but is uncommon.”

    Pantethine · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 8862. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
    2. 67748. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI

    Carfilzomib

    Listed in the ADVERSE REACTIONS section of the FDA label for Carfilzomib. Read the label on DailyMed ›

Reported for Pantethine but not commonly for Carfilzomib: bloating or gas.

Effects for Carfilzomib come from the ADVERSE REACTIONS section of its FDA label; effects for Pantethine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Carfilzomib

This page covers Pantethine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carfilzomib page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).

By severity: 3 major · 35 moderate.

From our pharmacist’s overview on the Carfilzomib page

“Every supplement on this page shares a single concern with carfilzomib (Kyprolis): extra strain on the liver. Carfilzomib is an IV chemotherapy for multiple myeloma, and that treatment is demanding enough without an herb quietly injuring the organ that has to keep pace.”

Reviewed by 2 · Jul 18, 2026

Open the Carfilzomib interaction page

One more smart check

Taking Pantethine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 302 real supplement products containing Pantethine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pantethine. Even though Pantethine itself has no known interaction with Carfilzomib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pantethine and Carfilzomib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pantethine
Top half

#406 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carfilzomib
Top half

#1,120 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pantethine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Pantethine and Carfilzomib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pantethine

What is Pantethine?

  • High cholesterol
  • High triglycerides
  • Heart health support
  • General vitamin B5 supplementation

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to replace standard treatments, so talk with your pharmacist or doctor before using it, especially if you have heart or cholesterol concerns.

Not applicable (a form of vitamin B5/pantothenic acid) · Capsules, tablets, softgels

An interaction check asks whether these two react with each other — it does not ask whether Pantethine is a good idea for someone in your situation. Here is what our Pantethine record says about it on its own.

Pantethine: dosing

There is no official, standardized dose of pantethine for any condition. They can help you decide whether pantethine makes sense for you and what amount may be appropriate.

From our Pantethine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pantethine monograph & all interactions
Medication

About Carfilzomib Injection

What Is Carfilzomib Injection Used For?

Brand name: Kyprolis

Kyprolis is used for adults with relapsed or refractory multiple myeloma. This is a blood cancer that has come back or has not responded to earlier treatment.

Kyprolis is used in combination with other medicines for people who have had one to three prior lines of therapy. It is also used alone for people who have had one or more prior lines of therapy.

See full Carfilzomib Injection drug information
Keep checking

Other Drugs & Pantethine

Browse every other medication we’ve checked against Pantethine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Pantethine page.

No interaction 2,707 drugs checked — show the list

We also checked Pantethine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Pantethine list.

See the full Pantethine interactions page
See every supplement checked against Carfilzomib, ranked by severity
Evidence & sources

Pantethine References

The 9 references that drive our Pantethine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pantethine and Carfilzomib Together: Common Questions

Is it safe to take Pantethine with Carfilzomib?
We do not list a known interaction between Pantethine and Carfilzomib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pantethine and Carfilzomib have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Pantethine and Carfilzomib combination checked?
Interactions in our licensed database are recorded against drug classes. Carfilzomib is filed under 1 classification, and Pantethine has documented interactions with 1 drug class — none of Carfilzomib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pantethine interact with any other medications?
Yes. Pantethine has 122 documented drug interactions in our database — Carfilzomib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Carfilzomib interact with any supplements?
Yes. Carfilzomib has documented interactions with 38 supplements in our database — Pantethine is not one of them. The Carfilzomib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pantethine monograph Uses, safety profile, and every drug interaction in one place Carfilzomib Injection drug information The full plain-English guide to this medication Carfilzomib supplement interactions Every supplement checked against Carfilzomib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Carfilzomib and Pantethine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.