Drug & supplement interaction

Peppermint + Minoxidil

Minoxidil brand names: Loniten, Rogaine, Minoxidil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Peppermint and Minoxidil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Peppermint and Minoxidil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Minoxidil and Peppermint in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Peppermint safety at a glance

Peppermint overall Use caution Peppermint tea and culinary use are generally safe, but concentrated oil should be used carefully.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amounts durin... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amounts durin... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Peppermint and peppermint oil have a number of theoretical interactions due to several lab and animal studies suggesting it can inhibit a variety of CYP metabolizing enzymes in the liver, including:

  • CYP2C9
  • CYP3A4
  • CYP2C19
  • CYP1A2

However, many of these interactions have not been seen in humans, and the likelihood of them being clinically significant is low. They are nevertheless important to be aware of.

There is no known interaction between peppermint and the drug in question here. They are considered safe to combine.

—

Still wondering about combining Minoxidil and Peppermint? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Minoxidil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Minoxidil is filed under 4 classifications — including vasodilators, antihypertensive drugs, topical drugs. Peppermint has documented interactions with 5 drug classes — the most serious being cyclosporine (neoral, sandimmune) (moderate), cytochrome p450 2c19 (cyp2c19) substrates (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Minoxidil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Peppermint Does Interact With Other Medications

Peppermint has 731 moderate, 65 minor known drug interactions in our database — Minoxidil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 731 Minor 65 No known interaction 2,034 (incl. Minoxidil)
Taking anything else?

Check Another of Your Medications Against Peppermint

Covers the 2,830 medications we’ve checked against Peppermint. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Peppermint and Minoxidil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe skin reaction Worth acting on Additional detail

    Peppermint

    “Topically, peppermint oil can cause skin irritation, burning, erythema, and contact dermatitis. Also, a case of severe mucosal injury has been reported for a patient who misused an undiluted over the counter mouthwash that contained peppermint and arnica oil in 70% alcohol.

    In large amounts, peppermint oil may cause chemical burns when used topically or orally.”

    Peppermint · Natural Medicines adverse-effect record, reported in burns.

    6 sources cited
    1. 3802. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
    2. 11781. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
    3. 31528. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
    4. 43338. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
    5. 68473. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
    6. 68457. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed

    Minoxidil

    Listed in the ADVERSE REACTIONS section of the FDA label for Minoxidil. Read the label on DailyMed ›

  • Swelling Additional detail

    Peppermint

    “One case of IgE-mediated anaphylaxis, characterized by sudden onset of lip and tongue swelling, tightness of throat, and shortness of breath, has been reported in a 69-year-old male who consumed peppermint candy. An allergic reaction after use of peppermint oil in combination with caraway oil has been reported in a patient with a history of bronchial asthma.”

    Peppermint · Natural Medicines adverse-effect record, reported in asthma.

    2 sources cited
    1. 89479. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
    2. 96344. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed

    Minoxidil

    Listed in the ADVERSE REACTIONS section of the FDA label for Minoxidil. Read the label on DailyMed ›

Reported for Peppermint but not commonly for Minoxidil: heartburn, liver problems, shortness of breath and increased appetite.

Effects for Minoxidil come from the ADVERSE REACTIONS section of its FDA label; effects for Peppermint come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Peppermint in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amounts during pregnancy or lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Minoxidil

This page covers Peppermint only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Minoxidil page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 113 moderate · 22 minor.

From our pharmacist’s overview on the Minoxidil page

“American hellebore heads the concerns for anyone taking minoxidil (Loniten, Rogaine), because even small amounts of its alkaloids lower blood pressure on their own, a dangerous match with one of the most potent pressure-lowering drugs prescribed. It is one of four major-rated entries among the 139 supplements and herbs on record, and t…”

Reviewed by 2 · Jul 18, 2026

Open the Minoxidil interaction page

One more smart check

Taking Peppermint as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,980 real supplement products containing Peppermint, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Peppermint. Even though Peppermint itself has no known interaction with Minoxidil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Peppermint and Minoxidil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Peppermint
Top 10%

#104 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Minoxidil
Top 5%

#114 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Peppermint reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Peppermint and Minoxidil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Peppermint

What is Peppermint?

Peppermint
  • Irritable bowel syndrome (IBS)
  • Indigestion and gas
  • Nausea
  • Tension headache (topical oil)
  • Colds and congestion
  • Freshening breath

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartburn and is not recommended in concentrated oil form for infants and young children. Check with your pharmacist or doctor before using it regularly, especially during pregnancy or breastfeeding.

Mentha x piperita · Lamiaceae · Leaves and essential oil · Tea, capsules (including enteric-coated peppermint oil), essential oil, tincture, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Peppermint is a good idea for someone in your situation. Here is what our Peppermint record says about it on its own.

Peppermint: dosing

There is no single official dose for peppermint, and the right amount depends on the form and the reason you are using it. For IBS, products usually come as standardized enteric-coated peppermint oil capsules with directions on the label. Teas are made by steeping the dried leaves in hot water.Because product strength varies widely, the best approach is to follow the directions on your specific product and not to exceed the recommended amount. Concentrated essential oil should never be swallowed unless it is in a product made for that purpose.

From our Peppermint monograph — the full record covers uses, side effects and every documented interaction.

Read the full Peppermint monograph & all interactions
Medication

About Minoxidil

What Is Minoxidil Used For?

Brand names: Loniten, Rogaine, Minoxidil

Minoxidil tablets are used to treat high blood pressure (hypertension) — specifically in patients who haven't responded well to other blood pressure medications. They are a powerful option reserved for difficult-to-control cases.

Topical minoxidil products — including solutions, sprays, gels, and foams from many brands — are used to regrow hair on the top of the scalp (called the vertex). Products labeled for men and for women may differ; for example, Bosley MD Regular Strength for Women and Dizop Minoxidil Topical Gel are each labeled for their specific intended users.

Most-Reported Side Effects for Minoxidil

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Adverse drug reaction 8,585 reports
Alopecia 3,803 reports
Application site pruritus 2,926 reports
Overdose 1,461 reports
Application site irritation 1,420 reports
See full Minoxidil drug information
Keep checking

Other Drugs & Peppermint

Browse every other medication we’ve checked against Peppermint — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
731Moderate
65Minor
2,033No known interaction
731 Moderate 65 Minor 2,033 No interaction
Moderate

731 interactions

Showing 60 of 731 moderate interactions — see all 731 on the Peppermint page.

Minor

65 interactions

Showing 60 of 65 minor interactions — see all 65 on the Peppermint page.

No interaction 2,033 drugs checked — show the list

We also checked Peppermint against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,033 medications checked with no known interaction — see the full Peppermint list.

See the full Peppermint interactions page
See every supplement checked against Minoxidil, ranked by severity
Evidence & sources

Peppermint References

The 41 references that drive our Peppermint monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Peppermint and Minoxidil Together: Common Questions

Is it safe to take Peppermint with Minoxidil?
We do not list a known interaction between Peppermint and Minoxidil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Peppermint and Minoxidil have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Peppermint and Minoxidil combination checked?
Interactions in our licensed database are recorded against drug classes. Minoxidil is filed under 4 classifications, and Peppermint has documented interactions with 5 drug classes — none of Minoxidil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Peppermint interact with any other medications?
Yes. Peppermint has 796 documented drug interactions in our database — Minoxidil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Minoxidil interact with any supplements?
Yes. Minoxidil has documented interactions with 139 supplements in our database — Peppermint is not one of them. The Minoxidil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Peppermint monograph Uses, safety profile, and every drug interaction in one place Minoxidil drug information The full plain-English guide to this medication Minoxidil supplement interactions Every supplement checked against Minoxidil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 41 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Minoxidil and Peppermint?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.