Drug & supplement interaction

Perilla + Azilsartan, Chlorthalidone

Azilsartan, Chlorthalidone brand name: Edarbyclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Perilla and Azilsartan, Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Perilla and Azilsartan, Chlorthalidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Azilsartan, Chlorthalidone and Perilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Perilla at all — not against Azilsartan, Chlorthalidone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Perilla safety at a glance

Perilla overall Use caution Generally well tolerated as a food, but supplement-strength products are not well studied.
Pregnancy Avoid Not enough safety data; avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Azilsartan, Chlorthalidone and Perilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Perilla and Azilsartan, Chlorthalidone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Perilla

    “Orally, many cases of anaphylaxis have been reported in adults and children who consumed perilla seeds. Some research suggests that oleosin is the major constituent responsible for perilla allergies.”

    Perilla · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 94313. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
    2. 110611. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

    Azilsartan, Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Azilsartan, Chlorthalidone. Read the label on DailyMed ›

  • A skin rash Additional detail

    Perilla

    “Topically, perilla may cause contact dermatitis (6,68664,94313).”

    Perilla · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 68664. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
    3. 94313. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed

    Azilsartan, Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Azilsartan, Chlorthalidone. Read the label on DailyMed ›

Reported for Perilla but not commonly for Azilsartan, Chlorthalidone: wheezing.

Effects for Azilsartan, Chlorthalidone come from the ADVERSE REACTIONS section of its FDA label; effects for Perilla come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Azilsartan, Chlorthalidone

This page covers Perilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azilsartan, Chlorthalidone page lists 266 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 222 moderate · 36 minor.

From our pharmacist’s overview on the Azilsartan, Chlorthalidone page

“Edarbyclor pairs azilsartan with chlorthalidone to lower blood pressure two ways, and that is exactly why this list warrants genuine care. Most entries either push blood pressure down further than intended or pile onto the diuretic's fluid and potassium effects.”

Reviewed by 2 · Jul 18, 2026

Open the Azilsartan, Chlorthalidone interaction page

One more smart check

Taking Perilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 199 real supplement products containing Perilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Perilla. Even though Perilla itself has no known interaction with Azilsartan, Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Perilla and Azilsartan, Chlorthalidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Perilla
Steady interest

#951 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Azilsartan, Chlorthalidone
Top 25%

#480 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Perilla and Azilsartan, Chlorthalidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Perilla

What is Perilla?

Perilla
  • Seasonal and food allergies
  • Asthma and airway inflammation
  • Atopic dermatitis (eczema)
  • Digestive upset
  • General anti-inflammatory support

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it should not replace proven treatments. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Perilla frutescens · Lamiaceae · Leaves, seeds, stem, and seed oil · Tea, capsules, seed oil, essential oil, dried leaf, culinary herb

An interaction check asks whether these two react with each other — it does not ask whether Perilla is a good idea for someone in your situation. Here is what our Perilla record says about it on its own.

Perilla: dosing

There is no well-established standard dose for perilla supplements. Products vary widely in their form and strength, from leaf teas to seed oil softgels to standardized extracts.The safest approach is to follow the directions on the product label and not to exceed them.

From our Perilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Perilla monograph & all interactions
Keep checking

Other Drugs & Perilla

Browse every other medication we’ve checked against Perilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Perilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perilla list.

See the full Perilla interactions page
See every supplement checked against Azilsartan, Chlorthalidone, ranked by severity
Evidence & sources

Perilla References

The 4 references that drive our Perilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Perilla and Azilsartan, Chlorthalidone Together: Common Questions

Is it safe to take Perilla with Azilsartan, Chlorthalidone?
We do not list a known interaction between Perilla and Azilsartan, Chlorthalidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Perilla and Azilsartan, Chlorthalidone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Azilsartan, Chlorthalidone interact with any supplements?
Yes. Azilsartan, Chlorthalidone has documented interactions with 266 supplements in our database — Perilla is not one of them. The Azilsartan, Chlorthalidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Perilla monograph Uses, safety profile, and every drug interaction in one place Azilsartan, Chlorthalidone supplement interactions Every supplement checked against Azilsartan, Chlorthalidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Azilsartan, Chlorthalidone and Perilla?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.