Medication interaction hub

What Supplements Interact with Azilsartan, Chlorthalidone?

Azilsartan, Chlorthalidone brand name: Edarbyclor. Every interaction below applies to the brands too.

266 Interactions 8 Major 222 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Azilsartan, Chlorthalidone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Azilsartan, Chlorthalidone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Edarbyclor pairs azilsartan with chlorthalidone to lower blood pressure two ways, and that is exactly why this list warrants genuine care. Most entries either push blood pressure down further than intended or pile onto the diuretic's fluid and potassium effects. A few are outright hazardous: activated charcoal can keep a dose from absorbing at all, calcium-rich products like dolomite raise the risk of dangerously high calcium with the chlorthalidone half, and yellow dock can deepen potassium loss.

Sun sensitivity is a quieter theme, with a couple dozen entries that can add to the skin reactions some people get on this medication, and dozens of herbs share a liver enzyme with azilsartan, which can shift levels. I would read the major-rated entries first and run any planned supplement past your pharmacist. Eight of the 266 ingredients carry a major rating; the other 258 split into 222 moderate and 36 minor.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 222 Minor 36 No known interaction 1,186

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Azilsartan, Chlorthalidone: Top Interactions at a Glance

The most significant Azilsartan, Chlorthalidone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 266 interacting ingredients — plus 1,186 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Azilsartan, Chlorthalidone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Azilsartan, Chlorthalidonei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Azilsartan, Chlorthalidonei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Azilsartan, Chlorthalidonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Azilsartan, Chlorthalidonei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Dolomite + Azilsartan, Chlorthalidonei

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction Major Likelihood Probable Lithium + Azilsartan, Chlorthalidonei

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Azilsartan, Chlorthalidone

All 1,452 ingredients in our database, ranked by severity — 266 with a Azilsartan, Chlorthalidone interaction on file and 1,186 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Azilsartan, Chlorthalidone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fish Oil with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Azilsartan, Chlorthalidone answer

Can you take Calcium with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Azilsartan, Chlorthalidone answer

Can you take Nattokinase with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Azilsartan, Chlorthalidone answer

Can you take Kiwi with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Azilsartan, Chlorthalidone answer

Can you take Korean Pine with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.

Full Korean Pine + Azilsartan, Chlorthalidone answer

Can you take L-citrulline with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotensio...

Full L-citrulline + Azilsartan, Chlorthalidone answer

Can you take Licorice with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might reduce the effects of antihypertensive drugs.

Full Licorice + Azilsartan, Chlorthalidone answer

Can you take Light Therapy with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Azilsartan, Chlorthalidone answer

Can you take Lily-of-the-valley with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.

Full Lily-of-the-valley + Azilsartan, Chlorthalidone answer

Can you take Lime with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Azilsartan, Chlorthalidone answer

Can you take Limonene with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction.

Full Limonene + Azilsartan, Chlorthalidone answer

Can you take Lovage with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.

Full Lovage + Azilsartan, Chlorthalidone answer

Can you take Maitake Mushroom with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Maitake Mushroom + Azilsartan, Chlorthalidone answer

Can you take Malic Acid with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.

Full Malic Acid + Azilsartan, Chlorthalidone answer

Can you take Manna with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, manna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Manna + Azilsartan, Chlorthalidone answer

Can you take Melatonin with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Azilsartan, Chlorthalidone answer

Can you take N-acetyl Cysteine (nac) with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Full N-acetyl Cysteine (nac) + Azilsartan, Chlorthalidone answer

Can you take Neem with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.

Full Neem + Azilsartan, Chlorthalidone answer

Can you take Niacin with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Azilsartan, Chlorthalidone answer

Can you take Noni with Azilsartan, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Full Noni + Azilsartan, Chlorthalidone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Azilsartan, Chlorthalidone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Azilsartan, Chlorthalidone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Azilsartan, Chlorthalidone sits in 7 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Angiotensin Receptor Blockers (Arbs) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Azilsartan, Chlorthalidone through this category.

Related: does Azilsartan, Chlorthalidone deplete any nutrients?

Azilsartan, Chlorthalidone has 7 reported nutrient associations in the research literature — see the Azilsartan, Chlorthalidone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Azilsartan, Chlorthalidone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Azilsartan, Chlorthalidone.

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Products that contain Azilsartan, Chlorthalidone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Azilsartan, Chlorthalidone.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Azilsartan, Chlorthalidone & Supplements: Common Questions

What supplements interact with Azilsartan, Chlorthalidone?
More than you might expect — 266 in total, though they are far from equal: 8 are rated major, 222 moderate, and 36 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Azilsartan, Chlorthalidone supplement interactions are the most serious?
The 8 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Azilsartan, Chlorthalidone?
Usually yes — most people on Azilsartan, Chlorthalidone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Edarbyclor have the same supplement interactions as Azilsartan, Chlorthalidone?
Yes — Edarbyclor all contain Azilsartan, Chlorthalidone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Azilsartan, Chlorthalidone deplete any vitamins or nutrients?
It might — Azilsartan, Chlorthalidone has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Azilsartan, Chlorthalidone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Azilsartan, Chlorthalidone and my other medications?
This page covers Azilsartan, Chlorthalidone against supplements and herbal ingredients. Checking Azilsartan, Chlorthalidone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.