Drug & supplement interaction

Peru Balsam + Duvelisib

Duvelisib brand name: Copiktra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Peru Balsam and Duvelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Peru Balsam and Duvelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Duvelisib and Peru Balsam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Peru Balsam at all — not against Duvelisib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Peru Balsam safety at a glance

Peru Balsam overall Use caution Generally used topically but is a common cause of allergic and contact skin reactions.
Pregnancy Likely Unsafe When used orally in medicinal amounts; avoid using. There is insufficient reliable information available about the safety of Peru balsam when used topically; av... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used topically because systemic toxicity to babies can occur following application of Peru balsam to the nipples of nursing mothers. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Duvelisib and Peru Balsam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Peru Balsam and Duvelisib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Peru Balsam

    “Peru balsam can cause kidney damage when taken orally or applied topically in large amounts (18). Topical use is associated with allergic contact dermatitis and other skin reactions (2,18).”

    Peru Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    “There are numerous reports of Peru balsam and its extracts causing allergic contact dermatitis, particularly when present in fragrances, cosmetics, and topical medicines. Among people who undergo patch testing for allergic contact dermatitis, reactions to Peru balsam occur in 4% to 8.4%, of whom 70% are women.”

    Peru Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 100650. Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
    2. 100908. Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
    3. 100909. Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.
    4. 100907. Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x. PubMed

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib. Read the label on DailyMed ›

Reported for Peru Balsam but not commonly for Duvelisib: kidney problems and hives.

Effects for Duvelisib come from the ADVERSE REACTIONS section of its FDA label; effects for Peru Balsam come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 765 voluntary FDA FAERS reports for Duvelisib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Peru Balsam in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in medicinal amounts; avoid using. There is insufficient reliable information available about the safety of Peru balsam when used topically; avoid using.

Lactation Possibly Unsafe

When used topically because systemic toxicity to babies can occur following application of Peru balsam to the nipples of nursing mothers.

Lactation Likely Unsafe

When used orally in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Duvelisib

This page covers Peru Balsam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duvelisib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Duvelisib page

“Duvelisib (Copiktra) treats certain blood cancers, and its supplement list deserves genuine care because the body clears it through a single enzyme, CYP3A4. Most of the 143 ingredients either block or speed up that enzyme, which can push duvelisib levels high enough to worsen side effects or low enough to weaken its grip on the cancer.”

Reviewed by 2 · Jul 18, 2026

Open the Duvelisib interaction page

How much people look this up

Where Peru Balsam and Duvelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Peru Balsam
Steady interest

#1,409 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Duvelisib
Top half

#1,320 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Peru Balsam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Peru Balsam and Duvelisib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Peru Balsam

What is Peru Balsam?

  • Wound and skin healing
  • Hemorrhoids
  • Coughs and sore throat
  • Antimicrobial and antiseptic
  • Diaper rash and minor skin irritation

Peru Balsam is a fragrant tree resin used mainly in topical products for wounds, hemorrhoids, and skin care, and sometimes in cough and throat remedies. Evidence for most uses is limited and largely traditional, and it is a well-known cause of allergic skin reactions, so use it cautiously and check with your pharmacist or doctor first.

Myroxylon balsamum var. pereirae · Fabaceae · Balsam (resin) obtained from the tree bark · Topical ointments, creams, suppositories, lozenges, and as a fragrance ingredient

An interaction check asks whether these two react with each other — it does not ask whether Peru Balsam is a good idea for someone in your situation. Here is what our Peru Balsam record says about it on its own.

Peru Balsam: dosing

There is no well-established standardized dose for Peru Balsam. It is usually found as one ingredient in finished topical products, lozenges, or syrups rather than as a stand-alone supplement.Follow the directions on the specific product label, and use the smallest amount needed.

From our Peru Balsam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Peru Balsam monograph & all interactions
Medication

About Duvelisib

What Is Duvelisib Used For?

Brand name: Copiktra

Copiktra (duvelisib) is used in adults with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) — meaning the cancer has returned or stopped responding to treatment — after at least two prior therapies.

Copiktra is also used for relapsed or refractory follicular lymphoma (FL) after at least two prior systemic therapies. The follicular lymphoma approval is based on overall response rate and is considered an accelerated approval; continued approval may depend on results from confirmatory trials. Copiktra is not intended for use as a first- or second-line treatment for any of these cancers.

Most-Reported Side Effects for Duvelisib

From FAERS, the FDA’s public side-effect reporting system (765 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 107 reports
Fatigue 78 reports
Prescribed underdose 65 reports
Nausea 49 reports
Pneumonia 41 reports
See full Duvelisib drug information
Keep checking

Other Drugs & Peru Balsam

Browse every other medication we’ve checked against Peru Balsam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Peru Balsam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Peru Balsam list.

See the full Peru Balsam interactions page
See every supplement checked against Duvelisib, ranked by severity
Evidence & sources

Peru Balsam References

The 7 references that drive our Peru Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
  5. Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x. PubMed
  6. Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
  7. Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Peru Balsam and Duvelisib Together: Common Questions

Is it safe to take Peru Balsam with Duvelisib?
We do not list a known interaction between Peru Balsam and Duvelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Peru Balsam and Duvelisib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Duvelisib interact with any supplements?
Yes. Duvelisib has documented interactions with 143 supplements in our database — Peru Balsam is not one of them. The Duvelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Peru Balsam monograph Uses, safety profile, and every drug interaction in one place Duvelisib drug information The full plain-English guide to this medication Duvelisib supplement interactions Every supplement checked against Duvelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Duvelisib and Peru Balsam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.