Drug & supplement interaction

Pheasant's Eye + Tolvaptan

Tolvaptan brand names: Samsca, Jynarque.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pheasant's Eye and Tolvaptan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pheasant's Eye and Tolvaptan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolvaptan and Pheasant's Eye in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pheasant's Eye safety at a glance

Pheasant's Eye overall Avoid The plant is poisonous and contains potent heart-affecting compounds with a very narrow safety margin.
Pregnancy Likely Unsafe When used orally for self-medication. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally for self-medication. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolvaptan and Pheasant's Eye? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tolvaptan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tolvaptan is filed under 4 classifications — including p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Pheasant's Eye has documented interactions with 7 drug classes — the most serious being digoxin (lanoxin) (major), corticosteroids (moderate) and diuretic drugs (moderate) — and none of Tolvaptan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pheasant's Eye Does Interact With Other Medications

Pheasant's Eye has 1 major, 155 moderate known drug interactions in our database — Tolvaptan isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 155 No known interaction 2,674 (incl. Tolvaptan)
Taking anything else?

Check Another of Your Medications Against Pheasant's Eye

Covers the 2,830 medications we’ve checked against Pheasant's Eye. Pick one to open its full report.

What to actually watch for

What Pheasant's Eye Itself Has Been Linked To

This is not an interaction — nothing below involves Tolvaptan. It is the side-effect record for Pheasant's Eye on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pheasant's Eye, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    “Orally, pheasant's eye might be unsafe due to its cardiac glycoside constituents.

    Serious Adverse Effects (Rare):

    Orally: Theoretically, digitalis-like effects including cardiac arrhythmia, diarrhea, nausea, and vomiting.”

    Pheasant's Eye · Natural Medicines adverse-effect record, reported in arrhythmia.

  • Diarrhea / Vomiting / Nausea Additional detail

    “Orally, adverse effects may include diarrhea, nausea, and vomiting (2). Pheasant's eye contains cardiac glycosides and can cause serious adverse effects when used orally without appropriate medical supervision (18,512,104545).”

    Pheasant's Eye · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 512. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
    4. 104545. Shang X, Miao X, Yang F, et al. The genus Adonis as an important cardiac folk medicine: A review of the ethnobotany, phytochemistry and pharmacology. Front Pharmacol. 2019;10:25. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Pheasant's Eye — expand a row for the licensed statement it rests on. We haven’t matched Tolvaptan to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolvaptan.

Special populations

Pheasant's Eye in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally for self-medication.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Tolvaptan Is Prescribed For, and What Pheasant's Eye Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tolvaptan is a prescription medicine with approved uses on its FDA label. Pheasant's Eye is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tolvaptan is prescribed for: Tolvaptan (brand name Jynarque) is used to slow the decline of kidney function in adults who have autosomal dominant polycystic kidney disease (ADPKD) — a genetic condition where fluid-filled cysts grow in the kidneys over time, gradually damaging them. It is specifically for people whose disease is at risk of progressing quickly. It does not cure ADPKD, but it works to slow down how fast the kidneys deteriorate, helping preserve kidney function for longer.

Pheasant's Eye has been studied for:

  • Heart failure studied, not established Pheasant's Eye has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Pheasant's Eye for heart failure

    Although there has been interest in using oral pheasant's eye for heart failure, there is insufficient reliable information about the clinical effects of pheasant's eye for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tolvaptan on your own; if you are taking Pheasant's Eye for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Tolvaptan

This page covers Pheasant's Eye only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolvaptan page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 104 moderate · 38 minor.

From our pharmacist’s overview on the Tolvaptan page

“People taking tolvaptan (Samsca, Jynarque) for polycystic kidney disease or low blood sodium are on a drug whose blood level depends heavily on one liver enzyme, CYP3A4, and that is exactly where most of these 145 supplements interfere. Grapefruit can drive tolvaptan levels up, St.”

Reviewed by 2 · Jul 18, 2026

Open the Tolvaptan interaction page

How much people look this up

Where Pheasant's Eye and Tolvaptan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pheasant's Eye
Steady interest

#1,304 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolvaptan
Steady interest

#1,787 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pheasant's Eye reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pheasant's Eye and Tolvaptan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pheasant's Eye

What is Pheasant's Eye?

  • Heart failure symptoms
  • Irregular or weak heartbeat
  • Fluid retention (as a diuretic)
  • Nervous heart complaints
  • Mild anxiety with heart palpitations

Pheasant's Eye (Adonis vernalis) is a toxic plant that contains heart-acting compounds similar to those in foxglove. It has been used in traditional and old European medicine for heart problems, but it is poisonous and has a very narrow margin of safety. You should not use it on your own — it should only ever be considered under direct medical supervision, if at all.

Adonis vernalis · Ranunculaceae · Dried above-ground parts (herb), including flowers, stems, and leaves · Tincture, dried herb extract, and standardized preparations (historically); rarely available as a non-prescription supplement

An interaction check asks whether these two react with each other — it does not ask whether Pheasant's Eye is a good idea for someone in your situation. Here is what our Pheasant's Eye record says about it on its own.

Pheasant's Eye: dosing

There is no safe, established over-the-counter dose for Pheasant's Eye, and we will not suggest one. Because the plant is toxic and the gap between an active dose and a poisonous dose is very small, dosing was historically left to trained practitioners using standardized, carefully measured preparations.We do not recommend using this plant on your own. If a product containing it is ever offered to you, do not take it without first speaking to a doctor or pharmacist. Always follow professional medical guidance rather than a product label alone.

From our Pheasant's Eye monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pheasant's Eye monograph & all interactions
Medication

About Tolvaptan (kidney disease)

What Is Tolvaptan (kidney disease) Used For?

Brand names: Samsca, Jynarque

Tolvaptan (brand name Jynarque) is used to slow the decline of kidney function in adults who have autosomal dominant polycystic kidney disease (ADPKD) — a genetic condition where fluid-filled cysts grow in the kidneys over time, gradually damaging them. It is specifically for people whose disease is at risk of progressing quickly.

It does not cure ADPKD, but it works to slow down how fast the kidneys deteriorate, helping preserve kidney function for longer.

See full Tolvaptan (kidney disease) drug information
Keep checking

Other Drugs & Pheasant's Eye

Browse every other medication we’ve checked against Pheasant's Eye — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
155Moderate
0Minor
2,673No known interaction
1 Major 155 Moderate 2,673 No interaction
Major

1 interaction

Moderate

155 interactions

Showing 60 of 155 moderate interactions — see all 155 on the Pheasant's Eye page.

No interaction 2,673 drugs checked — show the list

We also checked Pheasant's Eye against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Pheasant's Eye list.

See the full Pheasant's Eye interactions page
See every supplement checked against Tolvaptan, ranked by severity
Evidence & sources

Pheasant's Eye References

The 7 references that drive our Pheasant's Eye monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Shang X, Miao X, Yang F, et al. The genus Adonis as an important cardiac folk medicine: A review of the ethnobotany, phytochemistry and pharmacology. Front Pharmacol. 2019;10:25. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pheasant's Eye and Tolvaptan Together: Common Questions

Is it safe to take Pheasant's Eye with Tolvaptan?
We do not list a known interaction between Pheasant's Eye and Tolvaptan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Pheasant's Eye and Tolvaptan used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Pheasant's Eye in each. That is a conversation for your prescriber, especially if Tolvaptan is being adjusted to a target.
How was the Pheasant's Eye and Tolvaptan combination checked?
Interactions in our licensed database are recorded against drug classes. Tolvaptan is filed under 4 classifications, and Pheasant's Eye has documented interactions with 7 drug classes — none of Tolvaptan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pheasant's Eye interact with any other medications?
Yes. Pheasant's Eye has 156 documented drug interactions in our database — Tolvaptan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tolvaptan interact with any supplements?
Yes. Tolvaptan has documented interactions with 145 supplements in our database — Pheasant's Eye is not one of them. The Tolvaptan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pheasant's Eye monograph Uses, safety profile, and every drug interaction in one place Tolvaptan (kidney disease) drug information The full plain-English guide to this medication Tolvaptan supplement interactions Every supplement checked against Tolvaptan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolvaptan and Pheasant's Eye?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.