Drug & supplement interaction

Pheasant's Eye + Clobetasol

Clobetasol brand names: Temovate, Clobex.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pheasant's Eye has a moderate interaction with Clobetasol. Theoretically, using pheasant's eye with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Pheasant's Eye and Clobetasol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CORTICOSTEROIDS

Why this applies to Clobetasol

Clobetasol falls under CORTICOSTEROIDS — the group Pheasant's Eye interacts with.

Theoretically, using pheasant's eye with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Pheasant's eye contains cardiac glycosides. Concomitant use of corticosteroids with pheasant's eye can increase the therapeutic and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with Clobetasol: it's a strong steroid cream or scalp solution, so most of it stays right where you put it. The worry on file is mostly theoretical and applies to steroids taken by mouth or injection over a long time. Those can lower your body's potassium, and low potassium makes cardiac glycosides (the heart-acting compounds in Pheasant's Eye) more toxic.

With a topical product used as directed, very little gets into your bloodstream, so this concern is unlikely to matter much. But if you're using clobetasol over large areas, for a long stretch, or under wraps, more can absorb. Honestly, Pheasant's Eye is poisonous and shouldn't be used on your own at all. Please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Pheasant's Eye Also Interacts With Other Medications

Pheasant's Eye has 1 major, 154 moderate known drug interactions in our database — the Clobetasol one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 154 No known interaction 2,675 (incl. Clobetasol)
Taking anything else?

Check Another of Your Medications Against Pheasant's Eye

Covers the 2,830 medications we’ve checked against Pheasant's Eye. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Clobetasol

This page covers Pheasant's Eye only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clobetasol page lists 74 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lily-of-the-valley (major), St. John's Wort (major), Alder Buckthorn (moderate) and Bitter Melon (moderate).

By severity: 3 major · 53 moderate · 18 minor.

Open the Clobetasol interaction page

How much people look this up

Where Pheasant's Eye and Clobetasol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pheasant's Eye
Steady interest

#1,098 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clobetasol
Top half

#838 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Pheasant's Eye

What is Pheasant's Eye?

  • Heart failure symptoms
  • Irregular or weak heartbeat
  • Fluid retention (as a diuretic)
  • Nervous heart complaints
  • Mild anxiety with heart palpitations

Pheasant's Eye (Adonis vernalis) is a toxic plant that contains heart-acting compounds similar to those in foxglove. It has been used in traditional and old European medicine for heart problems, but it is poisonous and has a very narrow margin of safety. You should not use it on your own — it should only ever be considered under direct medical supervision, if at all.

Read the full Pheasant's Eye monograph & all interactions
Medication

About Clobetasol Topical

What Is Clobetasol Topical Used For?

Brand names: Temovate, Clobex

Clobetasol topical is used to treat moderate to severe scalp psoriasis and plaque psoriasis. It reduces the redness, scaling, and itching associated with these skin conditions.

Treatment is intended for short-term use only and should be limited to the minimum time needed to bring the condition under control. It should not be used on the face, groin, or underarm areas.

See full Clobetasol Topical drug information
Keep checking

Other Drugs & Pheasant's Eye

Browse every other medication we’ve checked against Pheasant's Eye — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
154Moderate
0Minor
2,674No known interaction
1 Major 154 Moderate 2,674 No interaction
Major

1 interaction

Moderate

154 interactions

Showing 60 of 154 moderate interactions — see all 154 on the Pheasant's Eye page.

No interaction 2,674 drugs checked — show the list

We also checked Pheasant's Eye against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,674 medications checked with no known interaction — see the full Pheasant's Eye list.

See the full Pheasant's Eye interactions page
See every supplement checked against Clobetasol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pheasant's Eye monograph › Uses, safety, and every drug interaction in one place Clobetasol supplement interactions › Every supplement checked against Clobetasol, ranked by severity Clobetasol Topical drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pheasant's Eye and Clobetasol Together: Common Questions

Can you take Pheasant's Eye with Clobetasol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Pheasant's Eye and Clobetasol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Clobetasol and Pheasant's Eye?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.