Drug & supplement interaction

Phenethylamine (pea) + Cinacalcet

Cinacalcet brand name: Sensipar.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Phenethylamine (pea) and Cinacalcet in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cinacalcet states a food rule worth keeping to.

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Interaction report

Phenethylamine (pea) and Cinacalcet

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cinacalcet and Phenethylamine (pea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenethylamine (pea) safety at a glance

Phenethylamine (pe... overall Use caution May affect heart rate and blood pressure, and human safety data for supplements is limited.

Pregnancy Avoid Not enough safety information; best avoided during pregnancy.

Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cinacalcet and Phenethylamine (pea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Cinacalcet

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cinacalcet is filed under a single classification — oral drugs. Phenethylamine (pea) has documented interactions with 2 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate) and serotonergic drugs (moderate) — and none of Cinacalcet’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenethylamine (pea) Does Interact With Other Medications

Phenethylamine (pea) has 187 moderate known drug interactions in our database — Cinacalcet isn’t one of them. If you take anything else, check it against the full list below.

Moderate 187 No known interaction 2,643 (incl. Cinacalcet)

Taking anything else?

Check Another of Your Medications Against Phenethylamine (pea)

Covers the 2,830 medications we’ve checked against Phenethylamine (pea). Pick one to open its full report.

What to actually watch for

What Phenethylamine (pea) Itself Has Been Linked To

This is not an interaction — nothing below involves Cinacalcet. It is the side-effect record for Phenethylamine (pea) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Phenethylamine (pea), this list is the first place to look.

Weight loss Additional detail
“A case of anxiety and agitation has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in anxiety.
1 source cited

24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
“A case of tachycardia has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, as well as caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in myasthenia gravis.
1 source cited

24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
A fast or pounding heartbeat Additional detail

Recorded for Phenethylamine (pea) in the same Natural Medicines adverse-effect record shown under Weight loss above.
Anxiety or restlessness Additional detail

Recorded for Phenethylamine (pea) in the same Natural Medicines adverse-effect record shown under Weight loss above.

Everything above comes from the Natural Medicines adverse-effect record for Phenethylamine (pea) — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Cinacalcet’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Cinacalcet column appears here.

How to take them

Some Cinacalcet Products Have a Food Rule — Phenethylamine (pea) Should Not Break It

At least one FDA label for a product containing Cinacalcet says to take it with food. If you take Phenethylamine (pea) on an empty stomach out of habit, keep them separate — and take Cinacalcet with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cinacalcet products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Cinacalcet tablets should be taken with food or shortly after a meal ( 2.1 ) • Tablets should always be taken whole and not divided ( 2.1 ) • Secondary HPT in patients with CKD on dialysis ( 2.2 ): o Starting dose is 30 mg once daily.

From the Dosage and Administration section of the FDA label we read for Cinacalcet — where that label names a specific product, the instruction is that product's. See the Cinacalcet drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cinacalcet

This page covers Phenethylamine (pea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cinacalcet page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Cinacalcet page

“Cinacalcet (Sensipar) is dosed carefully against blood calcium and parathyroid hormone levels, usually in people with kidney disease, so anything that changes how much of a dose actually gets absorbed deserves real attention. All 17 supplement interactions on file share a single mechanism.”

Reviewed by 2 · Jul 18, 2026

Open the Cinacalcet interaction page

One more smart check

Taking Phenethylamine (pea) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 208 real supplement products containing Phenethylamine (pea), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenethylamine (pea). Even though Phenethylamine (pea) itself has no known interaction with Cinacalcet, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenethylamine (pea) and Cinacalcet Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenethylamine (pea)

Top half

#499 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Cinacalcet

Steady interest

#1,529 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenethylamine (pea) reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phenethylamine (pea) and Cinacalcet records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Phenethylamine (pea)

What is Phenethylamine (pea)?

Mood support
Focus and concentration
Energy and pre-workout boost
Feeling of well-being
Athletic performance

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement is very limited, and it may raise blood pressure or heart rate, so people with heart or blood pressure problems should be cautious and check with a pharmacist or doctor first.

Not a plant part; a naturally occurring monoamine compound (made in the body and found in some foods) · Capsules, tablets, powders (often combined with other ingredients in pre-workout or 'mood' and 'focus' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Phenethylamine (pea) is a good idea for someone in your situation. Here is what our Phenethylamine (pea) record says about it on its own.

Phenethylamine (pea): dosing

There is no well-established or standardized dose for PEA supplements, and reliable studies on safe and effective amounts are lacking. Products vary widely in how much they contain and what else they are combined with.If you choose to try it, follow the directions on the product label and do not exceed the recommended amount.

From our Phenethylamine (pea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenethylamine (pea) monograph & all interactions

Medication

About Cinacalcet

What Is Cinacalcet Used For?

Brand name: Sensipar

Cinacalcet tablets are used to treat secondary hyperparathyroidism (overactive parathyroid glands caused by kidney disease) in adult patients with chronic kidney disease (CKD) who are on dialysis. This use applies to cinacalcet tablets, cinacalcet hydrochloride tablets, and Sensipar. Importantly, cinacalcet is not approved for CKD patients who are not on dialysis, due to a higher risk of dangerously low calcium levels.

Cinacalcet tablets are also used to lower high calcium levels (hypercalcemia) in adults with parathyroid carcinoma (a rare cancer of the parathyroid gland), and in adults with primary hyperparathyroidism who need surgery based on their calcium levels but cannot have that surgery.

Most-Reported Side Effects for Cinacalcet

From FAERS, the FDA’s public side-effect reporting system (48,763 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hospitalisation 6,957 reports

Laboratory test abnormal 4,226 reports

Nausea 2,405 reports

Vomiting 1,655 reports

Malaise 1,584 reports

See full Cinacalcet drug information

Keep checking

Other Drugs & Phenethylamine (pea)

Browse every other medication we’ve checked against Phenethylamine (pea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

187Moderate

0Minor

2,642No known interaction

187 Moderate 2,642 No interaction

Moderate

187 interactions

Showing 60 of 187 moderate interactions — see all 187 on the Phenethylamine (pea) page.

No interaction 2,642 drugs checked — show the list

We also checked Phenethylamine (pea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Phenethylamine (pea) list.

See the full Phenethylamine (pea) interactions page

See every supplement checked against Cinacalcet, ranked by severity

Evidence & sources

Phenethylamine (pea) References

The 9 references that drive our Phenethylamine (pea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenethylamine (pea) and Cinacalcet Together: Common Questions

Is it safe to take Phenethylamine (pea) with Cinacalcet?

We do not list a known interaction between Phenethylamine (pea) and Cinacalcet. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Phenethylamine (pea) and Cinacalcet at the same time of day?

At least one FDA label for a product containing Cinacalcet says to take it with food. If you take Phenethylamine (pea) on an empty stomach out of habit, keep them separate and take Cinacalcet with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cinacalcet products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Phenethylamine (pea) and Cinacalcet combination checked?

Interactions in our licensed database are recorded against drug classes. Cinacalcet is filed under 1 classification, and Phenethylamine (pea) has documented interactions with 2 drug classes — none of Cinacalcet's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Phenethylamine (pea) interact with any other medications?

Yes. Phenethylamine (pea) has 187 documented drug interactions in our database — Cinacalcet is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Cinacalcet interact with any supplements?

Yes. Cinacalcet has documented interactions with 17 supplements in our database — Phenethylamine (pea) is not one of them. The Cinacalcet interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenethylamine (pea) monograph Uses, safety profile, and every drug interaction in one place Cinacalcet drug information The full plain-English guide to this medication Cinacalcet supplement interactions Every supplement checked against Cinacalcet, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cinacalcet and Phenethylamine (pea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.