Drug & supplement interaction

Pokeweed + Piroxicam

Piroxicam brand names: Feldene, Feldene Gel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pokeweed and Piroxicam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pokeweed and Piroxicam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Piroxicam and Pokeweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pokeweed at all — not against Piroxicam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pokeweed safety at a glance

Pokeweed overall Avoid Pokeweed is toxic and has caused serious poisonings, so it is best avoided.
Pregnancy Likely Unsafe When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed i... Read the full pregnancy detail
Breastfeeding Likely Unsafe When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed i... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Piroxicam and Pokeweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Pokeweed and Piroxicam May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Seizures / Shortness of breath Worth acting on Additional detail

    Pokeweed

    “Pokeweed is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, all parts of the pokeweed plant can cause nausea, vomiting, cramping, abdominal pain, diarrhea, a burning sensation in the mouth and throat, weakness, hypotension, bloody emesis, bloody diarrhea, tachycardia, difficulty breathing, salivation, urinary incontinence, spasms, convulsions, severe thirst…”

    Pokeweed · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
    4. 3481. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
    5. 3482. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.

    Piroxicam

    Listed in the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed ›

  • A low platelet count Worth acting on Additional detail

    Pokeweed

    “Orally and topically, pokeweed has been reported to cause plasmacytosis, mitotic changes in peripheral blood cells, eosinophilia, thrombocytopenia, abnormal platelet morphology, and other hematologic abnormalities. When used topically, these effects are more likely to occur in individuals with cuts or abrasions on the skin. Protective gloves should be used to handle the plant.”

    Pokeweed · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    4 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3481. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
    4. 3482. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.

    Piroxicam

    Listed in the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed ›

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Pokeweed

    “Orally, all parts of the pokeweed plant can cause hypotension and tachycardia.”

    Pokeweed · Natural Medicines adverse-effect record, reported in hypotension.

    3 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed

    Piroxicam

    Listed in the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Pokeweed

    Recorded for Pokeweed in the same Natural Medicines adverse-effect record shown under Seizures / Shortness of breath above.

    Piroxicam

    Listed in the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed ›

  • Diarrhea / Stomach pain / Vomiting / Nausea reported in 13.3% of FDA reports for Piroxicam Additional detail

    Pokeweed

    “Orally, all parts of the pokeweed plant can cause nausea, vomiting, cramping, abdominal pain, diarrhea, a burning sensation in the mouth and throat, bloody emesis, and bloody diarrhea.”

    Pokeweed · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    2. 3478. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
    3. 3479. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed

    Piroxicam

    Listed in the ADVERSE REACTIONS section of the FDA label for Piroxicam, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Pokeweed but not commonly for Piroxicam: loss of bladder control, loss of vision and increased thirst.

Effects for Piroxicam come from the ADVERSE REACTIONS section of its FDA label; effects for Pokeweed come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 6,275 voluntary FDA FAERS reports for Piroxicam that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Pokeweed in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When pokeweed is used orally or applied topically; avoid using. Evidence suggests the pokeweed berry has uterine stimulant and abortifacient effects. Pokeweed is generally considered unsafe for any use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pokeweed or Piroxicam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pokeweed or Piroxicam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Piroxicam

This page covers Pokeweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Piroxicam page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 242 moderate · 36 minor.

From our pharmacist’s overview on the Piroxicam page

“Piroxicam (Feldene) is a potent, long-acting NSAID for arthritis pain, and since it already carries real stomach-bleeding risk on its own, my honest read is that this page calls for genuine caution rather than a quick skim. Most of the 285 interacting supplements share a single problem: they thin the blood or blunt platelets, stacking…”

Reviewed by 2 · Jul 18, 2026

Open the Piroxicam interaction page

One more smart check

Taking Pokeweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Pokeweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pokeweed. Even though Pokeweed itself has no known interaction with Piroxicam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pokeweed and Piroxicam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pokeweed
Steady interest

#1,089 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Piroxicam
Top half

#1,302 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pokeweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pokeweed and Piroxicam records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pokeweed

What is Pokeweed?

  • Joint pain and arthritis
  • Skin conditions
  • Swollen lymph nodes
  • Respiratory complaints
  • Traditional 'blood cleansing'

Pokeweed is a wild North American plant that is toxic in most of its raw forms, and there is no reliable evidence that it safely treats any condition. Poisonings have occurred from eating the berries, root, or improperly prepared greens. Because of its serious safety risks, most experts recommend avoiding it.

Phytolacca americana · Phytolaccaceae · Root, berries, leaves, and young shoots · Tincture, dried root, capsules, topical preparations, and traditionally cooked greens ('poke sallet')

An interaction check asks whether these two react with each other — it does not ask whether Pokeweed is a good idea for someone in your situation. Here is what our Pokeweed record says about it on its own.

Pokeweed: dosing

There is no established safe dose for pokeweed. Because the plant is toxic and the amount of active and harmful compounds varies widely, no reliable medicinal dose can be recommended.We do not provide dosing for pokeweed because of its poisoning risk. For most people, the safest choice is to avoid pokeweed altogether.

From our Pokeweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pokeweed monograph & all interactions
Medication

About Piroxicam

What Is Piroxicam Used For?

Brand names: Feldene, Feldene Gel

Piroxicam capsules are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It targets inflammation at the source to help improve day-to-day comfort and movement.

Piroxicam is not a cure for either condition — it manages symptoms. Your prescriber will weigh the benefits against the risks and aim for the lowest effective dose for the shortest time needed.

Most-Reported Side Effects for Piroxicam

From FAERS, the FDA’s public side-effect reporting system (6,347 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 980 reports
Rash 921 reports
Arthralgia 915 reports
Rheumatoid arthritis 856 reports
Fatigue 855 reports
See full Piroxicam drug information
Keep checking

Other Drugs & Pokeweed

Browse every other medication we’ve checked against Pokeweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pokeweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pokeweed list.

See the full Pokeweed interactions page
See every supplement checked against Piroxicam, ranked by severity
Evidence & sources

Pokeweed References

The 7 references that drive our Pokeweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
  4. Lewis WH, Smith PR. Poke root herbal tea poisoning. JAMA 1979;242:2759-60. DOI
  5. Roberge R, Brader E, Martin ML, et al. The root of evil-pokeweed intoxication. Ann Emerg Med 1986;15:470-3. PubMed
  6. Barker BE, Farnes P, LaMarche PH. Haematological effects of pokeweed. Lancet 1967;1:437.
  7. Kell SO, Rosenberg SA, Conlon TJ, Spyker DA. A peek at poke: mitogenicity and epidemiology. Vet Hum Toxicol 1982;24:36.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pokeweed and Piroxicam Together: Common Questions

Is it safe to take Pokeweed with Piroxicam?
We do not list a known interaction between Pokeweed and Piroxicam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pokeweed and Piroxicam have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Piroxicam interact with any supplements?
Yes. Piroxicam has documented interactions with 285 supplements in our database — Pokeweed is not one of them. The Piroxicam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pokeweed monograph Uses, safety profile, and every drug interaction in one place Piroxicam drug information The full plain-English guide to this medication Piroxicam supplement interactions Every supplement checked against Piroxicam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Piroxicam and Pokeweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.