Drug & supplement interaction

Reflexology + Tolazamide

Tolazamide brand name: Tolinase.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Reflexology and Tolazamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone interested in this? Share
Facebook Post Reddit Email
On this page
Interaction report

Reflexology and Tolazamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolazamide and Reflexology in our sources. This does not guarantee that the combination is completely free of risk — research on Reflexology alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Reflexology at all — not against Tolazamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Reflexology is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Reflexology safety at a glance

Reflexology overall Use caution Generally low-risk for most people, but it is not a substitute for medical care.
Pregnancy Possibly Safe When used appropriately. Reflexology has been used during pregnancy with apparent safety. Read the full pregnancy detail
Breastfeeding Possibly Safe When used appropriately. Reflexology has been used with apparent safety in lactating women. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolazamide and Reflexology? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Reflexology Itself Has Been Linked To

This is not an interaction — nothing below involves Tolazamide. It is the side-effect record for Reflexology on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Reflexology, this list is the first place to look.

  • Tiredness / Nausea Additional detail

    “Some practitioners of reflexology indicate that some patients, following a treatment session, can experience symptoms of malaise, fatigue, nausea, or flu-like symptoms. Reflexology is believed to stimulate the body to eliminate metabolic "toxins." These potential side effects are believed to be due to this process; however, there is no reliable scientific evidence to support this belief.”

    Reflexology · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 15827. Blunt E. Foot reflexology. Holist Nurs Pract 2006;20:257-9.

Everything above comes from the Natural Medicines adverse-effect record for Reflexology — expand a row for the licensed statement it rests on. We haven’t matched Tolazamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolazamide.

Special populations

Reflexology in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used appropriately. Reflexology has been used during pregnancy with apparent safety.

Lactation Possibly Safe

When used appropriately. Reflexology has been used with apparent safety in lactating women.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Tolazamide

This page covers Reflexology only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolazamide page lists 272 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 230 moderate · 40 minor.

From our pharmacist’s overview on the Tolazamide page

“Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood s…”

Reviewed by 2 · Jul 18, 2026

Open the Tolazamide interaction page

How much people look this up

Where Reflexology and Tolazamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Reflexology
Steady interest

#1,176 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolazamide
Top half

#823 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Reflexology reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Reflexology and Tolazamide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Reflexology

What is Reflexology?

  • Stress and relaxation
  • Anxiety
  • Pain relief
  • Sleep problems
  • Easing cancer-treatment symptoms
  • General well-being

Reflexology is a hands-on therapy where a practitioner applies pressure to specific points on the feet, hands, or ears, based on the idea that these points map to other parts of the body. Most people find it relaxing, and it appears generally safe, but solid evidence that it treats specific medical conditions is limited. It is best viewed as a complementary, relaxation-focused practice rather than a cure.

Not applicable (a hands-on therapy, not a plant or supplement) · In-person sessions with a trained reflexologist; foot, hand, or ear reflexology

An interaction check asks whether these two react with each other — it does not ask whether Reflexology is a good idea for someone in your situation. Here is what our Reflexology record says about it on its own.

Reflexology: dosing

There is no standardized "dose" for reflexology because it is a hands-on therapy, not something you take. Sessions commonly last around 30 to 60 minutes, and how often people go varies widely based on personal preference and budget.If you want to try it, look for a trained, reputable practitioner, share your health history, and start with an occasional session to see how you respond.

From our Reflexology monograph — the full record covers uses, side effects and every documented interaction.

Read the full Reflexology monograph & all interactions
Medication

About Tolazamide

What Is Tolazamide Used For?

Brand name: Tolinase

  • Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolazamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolazamide drug information
Keep checking

Other Drugs & Reflexology

Browse every other medication we’ve checked against Reflexology — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Reflexology against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Reflexology list.

See the full Reflexology interactions page
See every supplement checked against Tolazamide, ranked by severity
Evidence & sources

Reflexology References

The 73 references that drive our Reflexology monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blunt E. Foot reflexology. Holist Nurs Pract 2006;20:257-9.
  2. Stephenson NL, Dalton JA. Using reflexology for pain management. A review. J Holist Nurs 2003;21:179-91. PubMed
  3. Stephenson N, Dalton JA, Carlson J. The effect of foot reflexology on pain in patients with metastatic cancer. Appl Nurs Res 2003;16:284-6. PubMed
  4. Tipping L, Mackereth PA. A concept analysis: the effect of reflexology on homeostasis to establish and maintain lactation. Complement Ther Nurs Midwifery 2000;6:189-98. PubMed
  5. Mak HL, Cheon WC, Wong T, et al. Randomized controlled trial of foot reflexology for patients with symptomatic idiopathic detrusor overactivity. Int Urogynecol J Pelvic Floor Dysfunct 2007;18:653-8. PubMed
  6. Wilkinson IS, Prigmore S, Rayner CF. A randomised-controlled trail examining the effects of reflexology of patients with chronic obstructive pulmonary disease (COPD). Complement Ther Clin Pract 2006;12:141-7. PubMed
  7. McNeill JA, Alderdice FA, McMurray F. A retrospective cohort study exploring the relationship between antenatal reflexology and intranatal outcomes. Complement Ther Clin Pract 2006;12:119-25. PubMed
  8. Tiran D, Chummun H. The physiological basis of reflexology and its use as a potential diagnostic tool. Complement Ther Clin Pract 2005;11:58-64. PubMed
  9. Mollart L. Single-blind trial addressing the differential effects of two reflexology techniques versus rest, on ankle and foot oedema in late pregnancy. Complement Ther Nurs Midwifery 2003;9:203-8. PubMed
  10. Bishop E, McKinnon E, Weir E, Brown DW. Reflexology in the management of encopresis and chronic constipation. Paediatr Nurs 2003;15:20-1. DOI
  11. Ross CS, Hamilton J, Macrae G, et al. A pilot study to evaluate the effect of reflexology on mood and symptom rating of advanced cancer patients. Palliat Med 2002;16:544-5. PubMed
  12. Williamson J, White A, Hart A, Ernst E. Randomised controlled trial of reflexology for menopausal symptoms. BJOG 2002;109:1050-5. PubMed
  13. Tovey P. A single-blind trial of reflexology for irritable bowel syndrome. Br J Gen Pract 2002;52:19-23.
  14. Oleson T, Flocco W. Randomized controlled study of premenstrual symptoms treated with ear, hand, and foot reflexology. Obstet Gynecol 1993;82(6):906-11.
  15. Gunnarsdottir TJ, Jonsdottir H. Does the experimental design capture the effects of complementary therapy? A study using reflexology for patients undergoing coronary artery bypass graft surgery. J Clin Nurs 2007;16(4):777-85. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Reflexology While Taking Tolazamide: Common Questions

Is it safe to have Reflexology while taking Tolazamide?
We do not list a known interaction between Reflexology and Tolazamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tolazamide interact with any supplements?
Yes. Tolazamide has documented interactions with 272 supplements in our database — Reflexology is not one of them. The Tolazamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Reflexology monograph Uses, safety profile, and every drug interaction in one place Tolazamide drug information The full plain-English guide to this medication Tolazamide supplement interactions Every supplement checked against Tolazamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 73 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolazamide and Reflexology?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.