Drug & supplement interaction

Scopolia + Nadolol

Nadolol brand names: Corgard, Nadolol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Scopolia and Nadolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Scopolia and Nadolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nadolol and Scopolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Scopolia safety at a glance

Scopolia overall Avoid Scopolia is toxic and unsafe for self-medication because of its potent anticholinergic alkaloids.
Pregnancy Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nadolol and Scopolia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Nadolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Nadolol is filed under 5 classifications — including beta-blockers, antihypertensive drugs, seizure threshold lowering drugs. Scopolia has documented interactions with 3 drug classes — the most serious being anticholinergic drugs (major), quinidine (major) and tricyclic antidepressants (tcas) (major) — and none of Nadolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Scopolia Does Interact With Other Medications

Scopolia has 200 major, known drug interactions in our database — Nadolol isn’t one of them. If you take anything else, check it against the full list below.

Major 200 No known interaction 2,630 (incl. Nadolol)
Taking anything else?

Check Another of Your Medications Against Scopolia

Covers the 2,830 medications we’ve checked against Scopolia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Scopolia and Nadolol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations / Confusion Worth acting on Additional detail

    Scopolia

    “Scopolia is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, scopolia root acts on the central nervous system and can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, adverse effects of scopolia are generally related to the central nervous system. Scopolia root can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18). Early symptoms of scopolia poisoning include reddened skin, dry mouth, and tachycardic arrhythmias (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Dry mouth / Constipation Additional detail

    Scopolia

    Recorded for Scopolia in the same Natural Medicines adverse-effect record shown under Hallucinations / Confusion above.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

Reported for Scopolia but not commonly for Nadolol: trouble passing urine, anxiety or restlessness and a fast or pounding heartbeat.

Effects for Nadolol come from the ADVERSE REACTIONS section of its FDA label; effects for Scopolia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 7,530 voluntary FDA FAERS reports for Nadolol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Scopolia in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the root or rhizome is used orally as a medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Nadolol

This page covers Scopolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nadolol page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Green Tea (major) and Indian Snakeroot (major).

By severity: 6 major · 119 moderate · 20 minor.

From our pharmacist’s overview on the Nadolol page

“If you take nadolol (Corgard) for blood pressure, angina, or heart rhythm, treat this list with real care, and green tea is the surprise at the top. In a clinical study, green tea cut nadolol blood levels by roughly 85 percent, which can quietly leave you undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Nadolol interaction page

How much people look this up

Where Scopolia and Nadolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Scopolia
Steady interest

#1,151 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nadolol
Top half

#1,166 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Scopolia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Scopolia and Nadolol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Scopolia

What is Scopolia?

Scopolia
  • Stomach and intestinal cramps
  • Motion sickness
  • Spasms and colic
  • Excess saliva or secretions
  • Pain relief (traditional)

Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scopolamine. While these compounds are used in carefully measured prescription medicines, the raw plant is dangerous for self-treatment and should never be used without a doctor's supervision.

Scopolia carniolica · Solanaceae · Rhizome (root) and leaves · Standardized extracts, tinctures, and as a source for isolated alkaloid drugs (rarely sold as a stand-alone supplement)

An interaction check asks whether these two react with each other — it does not ask whether Scopolia is a good idea for someone in your situation. Here is what our Scopolia record says about it on its own.

Scopolia: dosing

There is no established safe over-the-counter dose of Scopolia for self-care. Because the plant contains powerful and toxic alkaloids, even small differences in amount can be the difference between an effect and a poisoning.The purified alkaloids found in Scopolia are dosed precisely in prescription products by trained professionals. When in doubt, do not use it.

From our Scopolia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Scopolia monograph & all interactions
Medication

About Nadolol

What Is Nadolol Used For?

Brand names: Corgard, Nadolol

Nadolol tablets are used for two main conditions: high blood pressure (hypertension) and angina pectoris (ongoing chest pain caused by reduced blood flow to the heart). Lowering high blood pressure reduces the risk of stroke and heart attack.

For high blood pressure, nadolol may be prescribed on its own or combined with other blood pressure medications, especially thiazide-type diuretics (water pills). For angina, it is used for long-term management to help reduce how often chest pain occurs.

Most-Reported Side Effects for Nadolol

From FAERS, the FDA’s public side-effect reporting system (7,530 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Macular degeneration 831 reports
Nausea 673 reports
Headache 603 reports
Fatigue 526 reports
Weight decreased 464 reports
See full Nadolol drug information
Keep checking

Other Drugs & Scopolia

Browse every other medication we’ve checked against Scopolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

200Major
0Moderate
0Minor
2,629No known interaction
200 Major 2,629 No interaction
Major

200 interactions

Showing 60 of 200 major interactions — see all 200 on the Scopolia page.

No interaction 2,629 drugs checked — show the list

We also checked Scopolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,629 medications checked with no known interaction — see the full Scopolia list.

See the full Scopolia interactions page
See every supplement checked against Nadolol, ranked by severity
Evidence & sources

Scopolia References

The 4 references that drive our Scopolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Scopolia and Nadolol Together: Common Questions

Is it safe to take Scopolia with Nadolol?
We do not list a known interaction between Scopolia and Nadolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Scopolia and Nadolol have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Scopolia and Nadolol combination checked?
Interactions in our licensed database are recorded against drug classes. Nadolol is filed under 5 classifications, and Scopolia has documented interactions with 3 drug classes — none of Nadolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Scopolia interact with any other medications?
Yes. Scopolia has 200 documented drug interactions in our database — Nadolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Nadolol interact with any supplements?
Yes. Nadolol has documented interactions with 145 supplements in our database — Scopolia is not one of them. The Nadolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Scopolia monograph Uses, safety profile, and every drug interaction in one place Nadolol drug information The full plain-English guide to this medication Nadolol supplement interactions Every supplement checked against Nadolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nadolol and Scopolia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.