Drug & supplement interaction

Secretin + Betaxolol

Betaxolol brand names: Kerlone, Betoptic.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Secretin and Betaxolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Secretin and Betaxolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Betaxolol and Secretin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Secretin at all — not against Betaxolol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Secretin safety at a glance

Secretin overall Use caution Secretin is a prescription injectable given only by trained healthcare providers, not a self-care supplement.
Pregnancy Not established Safety during pregnancy is not well established; use only if a doctor decides the benefit outweighs the risk.
Breastfeeding Not established It is not known whether secretin is safe during breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Betaxolol and Secretin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Secretin Itself Has Been Linked To

This is not an interaction — nothing below involves Betaxolol. It is the side-effect record for Secretin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Secretin, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

  • Blood clots Worth acting on Additional detail

    “Intravenously, the most common adverse reaction to secretin is flushing of the face, neck, and chest immediately after infusion. Less common potential adverse effects are vomiting, diarrhea, fainting, venous thrombosis (15), fever, and tachycardia. Some patients can have allergic reactions including urticaria, erythema, and anaphylaxis.”

    Secretin · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 6007. Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
    2. 7052. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
    3. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    4. 100741. Law R, Vargo JJ, Stevens T. Acute pancreatitis and aspiration pneumonia after administration of synthetic human secretin (with video). Gastrointest Endosc. 2011;74(5):1166-8. PubMed

    “Intravenously, secretin might cause venous thrombosis and tachycardia in rare cases.”

    Secretin · Natural Medicines adverse-effect record, reported in irregular heartbeat.

    2 sources cited
    1. 6007. Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
    2. 7052. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
  • Pancreatitis Worth acting on Additional detail

    “Intravenously, secretin might cause abdominal pain, nausea, vomiting, and diarrhea. Secretin has also been linked with the development of pancreatitis.”

    Secretin · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 6007. Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
    2. 7052. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
    3. 106325. Brandler J, Miller LJ, Wang XJ, et al. Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial. Am J Physiol Gastrointest Liver Physiol 2020;318(4):G635-G645. PubMed
    4. 100741. Law R, Vargo JJ, Stevens T. Acute pancreatitis and aspiration pneumonia after administration of synthetic human secretin (with video). Gastrointest Endosc. 2011;74(5):1166-8. PubMed
  • Fainting Worth acting on Additional detail

    Recorded for Secretin in the same Natural Medicines adverse-effect record shown under Blood clots above.

  • A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Intravenously, secretin might cause allergic reactions including urticaria, erythema, and anaphylaxis. Because of the potential for these hypersensitivity reactions, a 0.1 mL test dose is often administered prior to giving a full dose.”

    Secretin · Natural Medicines adverse-effect record, reported in erythema.

    1 source cited
    1. 7052. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
  • A higher chance of infection Worth acting on Additional detail

    “Intravenously, secretin has also been linked with the development of aspiration pneumonia.”

    Secretin · Natural Medicines adverse-effect record, reported in pneumonia.

    1 source cited
    1. 100741. Law R, Vargo JJ, Stevens T. Acute pancreatitis and aspiration pneumonia after administration of synthetic human secretin (with video). Gastrointest Endosc. 2011;74(5):1166-8. PubMed
  • Flushing Additional detail

    “Intravenously, the most common adverse reaction to secretin is flushing of the face, neck, and chest immediately after infusion.”

    Secretin · Natural Medicines adverse-effect record, reported in niacin-induced flushing.

    2 sources cited
    1. 6007. Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
    2. 7052. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
  • A fast or pounding heartbeat Additional detail

    Recorded for Secretin in the same Natural Medicines adverse-effect record shown under Blood clots above.

  • Fever Additional detail

    Recorded for Secretin in the same Natural Medicines adverse-effect record shown under Blood clots above.

Showing the 10 most notable of 14 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Secretin — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Betaxolol’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Betaxolol column appears here.

From our Q&A

Questions About Secretin or Betaxolol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Secretin or Betaxolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Betaxolol

This page covers Secretin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Betaxolol page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 118 moderate · 20 minor.

From our pharmacist’s overview on the Betaxolol page

“Five of the 143 supplement ingredients that interact with betaxolol (Kerlone tablets for blood pressure, Betoptic drops for glaucoma) carry a major rating, so approach this page with real caution. Since betaxolol is a beta-blocker, nearly everything here plays on blood pressure.”

Reviewed by 2 · Jul 18, 2026

Open the Betaxolol interaction page

How much people look this up

Where Secretin and Betaxolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Secretin
Steady interest

#839 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Betaxolol
Top 10%

#265 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Secretin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Secretin and Betaxolol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Secretin

What is Secretin?

  • Diagnostic testing of pancreas function
  • Diagnosing gastrinoma (Zollinger-Ellison syndrome)
  • Aiding pancreatic imaging procedures
  • Investigational use in autism (not proven)

Secretin is a natural digestive hormone, not a typical dietary supplement. As a medicine it is an FDA-approved injectable used mainly for diagnostic tests of the pancreas, and it must be given by a healthcare professional. Despite past interest, there is strong evidence that secretin does NOT help autism, and it should never be self-administered.

Hormone produced naturally in the small intestine; pharmaceutical versions are made synthetically or from animal sources · Injectable solution (prescription, used in medical settings)

An interaction check asks whether these two react with each other — it does not ask whether Secretin is a good idea for someone in your situation. Here is what our Secretin record says about it on its own.

Secretin: dosing

There is no general supplement dose for secretin because it is not used as a supplement. It is a prescription injectable, and the dose is calculated by your healthcare provider based on your body and the specific test being done.You should never try to obtain or self-administer secretin. Dosing, timing, and monitoring are all handled by trained medical staff during a procedure.

From our Secretin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Secretin monograph & all interactions
Medication

About Betaxolol

What Is Betaxolol Used For?

Brand names: Kerlone, Betoptic

Betaxolol eye drops (including Betoptic S) are used to lower elevated intraocular pressure (pressure inside the eye) in people with chronic open-angle glaucoma or ocular hypertension (high eye pressure without glaucoma). The eye drops may be used alone or alongside other glaucoma medications.

Betaxolol tablets are used to manage high blood pressure (hypertension). They can be used on their own or combined with other blood pressure medications, particularly thiazide-type diuretics.

See full Betaxolol drug information
Keep checking

Other Drugs & Secretin

Browse every other medication we’ve checked against Secretin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Secretin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Secretin list.

See the full Secretin interactions page
See every supplement checked against Betaxolol, ranked by severity
Evidence & sources

Secretin References

The 14 references that drive our Secretin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Horvath K, Stefatos G, Sokolski KN. Improved social and language skills after secretin administration. J Assoc Acad Minor Phys 1998;9:9-15.
  3. Tympner F, Rosch W. The treatment of chronic recurrent pancreatitis with depot secretin-a preliminary report. Hepatogastroenterology 1986;33:159-62.
  4. Coniglio SJ, Lewis JD, Lang C, et al. A randomized, double-blind, placebo-controlled trial of single-dose intravenous secretin as treatment for children with autism. J Pediatr 2001;138:649-55. PubMed
  5. Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
  6. Sandler AD, Sutton KA, DeWeese J, et al. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. N Engl J Med 1999;341(24):1801-6. PubMed
  7. Lightdale JR, Hayer C, Duer A, et al. Effects of intravenous secretin on language and behavior of children with autism and gastrointestinal symptoms: a single-blinded, open-label pilot study. Pediatrics 2001;108:90. PubMed
  8. Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
  9. Honomichl RD, Goodlin-Jones BL, Burnham MM, Hansen RL, Anders TF. Secretin and sleep in children with autism. Child Psychiatry Hum Dev. 2002;33(2):107-23. PubMed
  10. Law R, Vargo JJ, Stevens T. Acute pancreatitis and aspiration pneumonia after administration of synthetic human secretin (with video). Gastrointest Endosc. 2011;74(5):1166-8. PubMed
  11. Sheitman BB, Knable MB, Jarskog LF, et al. Secretin for refractory schizophrenia. Schizophr Res. 2004;66(2-3):177-81. PubMed
  12. Levenick JM, Andrews CL, Purich ED, Gordon SR, Gardner TB. A phase II trial of human secretin infusion for refractory type B pain in chronic pancreatitis. Pancreas. 2013;42(4):596-600. PubMed
  13. Williams K, Wray JA, Wheeler DM. Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2012;2012(4):CD003495. PubMed
  14. Brandler J, Miller LJ, Wang XJ, et al. Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial. Am J Physiol Gastrointest Liver Physiol 2020;318(4):G635-G645. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Secretin and Betaxolol Together: Common Questions

Is it safe to take Secretin with Betaxolol?
We do not list a known interaction between Secretin and Betaxolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Betaxolol interact with any supplements?
Yes. Betaxolol has documented interactions with 143 supplements in our database — Secretin is not one of them. The Betaxolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Secretin monograph Uses, safety profile, and every drug interaction in one place Betaxolol drug information The full plain-English guide to this medication Betaxolol supplement interactions Every supplement checked against Betaxolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Betaxolol and Secretin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.