Drug & supplement interaction

Self-heal + Selinexor

Selinexor brand name: Xpovio.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Self-heal and Selinexor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Self-heal and Selinexor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selinexor and Self-heal in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Self-heal at all — not against Selinexor, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Self-heal safety at a glance

Self-heal overall Use caution Generally used in foods and teas, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided.
Breastfeeding Avoid No reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selinexor and Self-heal? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Self-heal and Selinexor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite reported in 16.4% of FDA reports for Selinexor Additional detail

    Self-heal

    “Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea (12). A combination product containing self-heal, Clematis mandshurica, and Chinese cucumber has been reported to cause epigastric pain, abdominal discomfort, nausea, reduced appetite, and dyspepsia. It is not clear if these effects are due to self-heal, the other ingredients, or the combination.”

    Self-heal · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 101041. Song YW, Lee EY, Koh EM, et al. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clini

    Selinexor

    Listed in the ADVERSE REACTIONS section of the FDA label for Selinexor, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea / Diarrhea / Vomiting reported in 30.6% of FDA reports for Selinexor Additional detail

    Self-heal

    “Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea. Orally and topically, self-heal has been reported to cause allergic reactions in sensitive individuals (12).”

    Self-heal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Selinexor

    Listed in the ADVERSE REACTIONS section of the FDA label for Selinexor, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Self-heal but not commonly for Selinexor: stomach upset and an allergic reaction.

Effects for Selinexor come from the ADVERSE REACTIONS section of its FDA label; effects for Self-heal come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,359 voluntary FDA FAERS reports for Selinexor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Selinexor

This page covers Self-heal only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selinexor page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Selinexor page

“Selinexor (Xpovio) treats multiple myeloma and certain lymphomas, and its side effects are rough enough at intended doses that any shift in its blood level deserves genuine caution. Almost all of the 138 supplements and herbs listed here, 121 of them, can change how a liver enzyme called CYP3A4 handles the drug, pushing its level up or…”

Reviewed by 2 · Jul 18, 2026

Open the Selinexor interaction page

One more smart check

Taking Self-heal as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Self-heal, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Self-heal. Even though Self-heal itself has no known interaction with Selinexor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Self-heal and Selinexor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Self-heal
Steady interest

#1,099 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selinexor
Top half

#1,119 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Self-heal reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Self-heal and Selinexor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Self-heal

What is Self-heal?

  • Sore throat and mouth infections
  • Cold sores and skin irritation
  • Inflammation
  • General immune support
  • Minor wounds (topical)

Self-heal (Prunella vulgaris) is a traditional herb used for sore throats, skin issues, and inflammation, mainly in folk and traditional Chinese medicine. Human evidence for its benefits is very limited, so it should be viewed as an unproven remedy. If you want to try it, talk with your pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Prunella vulgaris · Lamiaceae · Aerial parts (flowering spikes, leaves, and stems) · Tea, tincture, capsules, dried herb, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Self-heal is a good idea for someone in your situation. Here is what our Self-heal record says about it on its own.

Self-heal: dosing

There is no well-established, standardized dose for self-heal. Traditional use as a tea involves steeping the dried herb in hot water, but commercial products vary widely in strength and form.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Self-heal monograph — the full record covers uses, side effects and every documented interaction.

Read the full Self-heal monograph & all interactions
Medication

About Selinexor

What Is Selinexor Used For?

Brand name: Xpovio

Xpovio (selinexor) is used to treat multiple myeloma in adults. When used together with bortezomib and dexamethasone, it is for adults who have had at least one prior treatment. This combination is sometimes called XVd.

Xpovio is also used with dexamethasone alone (called Xd) for adults with relapsed or refractory multiple myeloma — meaning the cancer came back or stopped responding — who have already tried at least four prior therapies and whose disease no longer responds to several other standard drug types.

See full Selinexor drug information
Keep checking

Other Drugs & Self-heal

Browse every other medication we’ve checked against Self-heal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Self-heal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Self-heal list.

See the full Self-heal interactions page
See every supplement checked against Selinexor, ranked by severity
Evidence & sources

Self-heal References

The 2 references that drive our Self-heal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Song YW, Lee EY, Koh EM, et al. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clini

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Self-heal and Selinexor Together: Common Questions

Is it safe to take Self-heal with Selinexor?
We do not list a known interaction between Self-heal and Selinexor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Self-heal and Selinexor have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Selinexor interact with any supplements?
Yes. Selinexor has documented interactions with 138 supplements in our database — Self-heal is not one of them. The Selinexor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Self-heal monograph Uses, safety profile, and every drug interaction in one place Selinexor drug information The full plain-English guide to this medication Selinexor supplement interactions Every supplement checked against Selinexor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selinexor and Self-heal?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.