Drug & supplement interaction

Skunk Cabbage + Ceftriaxone

Ceftriaxone brand name: Rocephin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Skunk Cabbage and Ceftriaxone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Skunk Cabbage and Ceftriaxone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ceftriaxone and Skunk Cabbage in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Skunk Cabbage at all — not against Ceftriaxone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Skunk Cabbage safety at a glance

Skunk Cabbage overall Use caution Fresh plant can cause severe mouth and throat irritation, and safety has not been well studied.
Pregnancy Possibly Unsafe When used orally; avoid using. It may affect the menstrual cycle, and its irritant properties may stimulate uterine contractions. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. It may affect the menstrual cycle, and its irritant properties may stimulate uterine contractions. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ceftriaxone and Skunk Cabbage? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Skunk Cabbage Itself Has Been Linked To

This is not an interaction — nothing below involves Ceftriaxone. It is the side-effect record for Skunk Cabbage on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Skunk Cabbage, this list is the first place to look.

  • Itching Additional detail

    “Topically, fresh skunk cabbage can cause severe itching, inflammation, and blistering (4,4502).”

    Skunk Cabbage · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 4502. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.
  • Stomach pain / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, large amounts of skunk cabbage have been reported to cause nausea and vomiting (18,4502). Excessive use can cause abdominal cramps, burning, blistering in the mouth and throat, nausea, and watery or bloody diarrhea (12).”

    Skunk Cabbage · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 4502. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.
    3. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  • Dizziness / Headache Additional detail

    “Orally, large amounts of skunk cabbage have been reported to cause headache, vertigo, and vision dimming (18,4502).”

    Skunk Cabbage · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 4502. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.

Everything above comes from the Natural Medicines adverse-effect record for Skunk Cabbage — expand a row for the licensed statement it rests on. We haven’t matched Ceftriaxone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Ceftriaxone.

Special populations

Skunk Cabbage in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using. It may affect the menstrual cycle, and its irritant properties may stimulate uterine contractions.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Ceftriaxone Is Prescribed For, and What Skunk Cabbage Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ceftriaxone is a prescription medicine with approved uses on its FDA label. Skunk Cabbage is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ceftriaxone is prescribed for: Ceftriaxone Injection is used to treat bacterial infections in many parts of the body, including the lungs (lower respiratory tract infections), urinary tract, skin, bones and joints, abdomen, and bloodstream (septicemia). It also treats bacterial meningitis (infection of the lining around the brain and spinal cord), pelvic inflammatory disease, acute bacterial ear infections (otitis media), and gonorrhea. In addition, a single dose of ceftriaxone may be given before certain surgeries — such as hysterectomy, gallbladder surgery, or coronary artery bypass surgery — to help prevent postoperative infection. It works only against bacterial infections; it will not treat viral illnesses like the flu or a cold.

Skunk Cabbage has been studied for:

  • Respiratory tract infections studied, not established Skunk Cabbage has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Skunk Cabbage for respiratory tract infections

    Although there has been interest in using oral skunk cabbage for respiratory tract infections, including bronchitis and pertussis, there is insufficient reliable information about the clinical effects of skunk cabbage for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ceftriaxone on your own; if you are taking Skunk Cabbage for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Ceftriaxone

This page covers Skunk Cabbage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ceftriaxone page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Calcium (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 39 moderate · 2 minor.

From our pharmacist’s overview on the Ceftriaxone page

“Kidney strain is the risk to understand first on this page. Ceftriaxone (Rocephin) is an injectable antibiotic used for serious infections, and three of the 44 supplements on file carry major ratings, two of them because they can harm the kidneys on their own: Siberian cocklebur and asarabacca, which is often contaminated with kidney-d…”

Reviewed by 2 · Jul 18, 2026

Open the Ceftriaxone interaction page

One more smart check

Taking Skunk Cabbage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 60 real supplement products containing Skunk Cabbage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Skunk Cabbage. Even though Skunk Cabbage itself has no known interaction with Ceftriaxone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Skunk Cabbage and Ceftriaxone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Skunk Cabbage
Steady interest

#917 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ceftriaxone
Top half

#1,136 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Skunk Cabbage reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Skunk Cabbage and Ceftriaxone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Skunk Cabbage

What is Skunk Cabbage?

Skunk Cabbage
  • Cough and bronchitis
  • Asthma and respiratory complaints
  • Skin problems and wounds (poultice)
  • Inflammation
  • Nerve and muscle complaints

Skunk cabbage is a North American plant with a long history of traditional use for breathing and skin problems, but there is very little modern scientific evidence to support these uses or to confirm it is safe. The fresh plant contains sharp calcium oxalate crystals that can cause intense burning and irritation. Because safety is poorly understood, talk with a pharmacist or doctor before using it.

Symplocarpus foetidus · Araceae · Root (rhizome) and sometimes the leaves · Dried root, tincture, extract, poultice; rarely capsules or tea

An interaction check asks whether these two react with each other — it does not ask whether Skunk Cabbage is a good idea for someone in your situation. Here is what our Skunk Cabbage record says about it on its own.

Skunk Cabbage: dosing

There is no established or standardized dose for skunk cabbage. Traditional preparations varied widely, and there is not enough modern research to recommend a safe and effective amount.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Skunk Cabbage monograph — the full record covers uses, side effects and every documented interaction.

Read the full Skunk Cabbage monograph & all interactions
Medication

About Ceftriaxone Injection

What Is Ceftriaxone Injection Used For?

Brand name: Rocephin

Ceftriaxone Injection is used to treat bacterial infections in many parts of the body, including the lungs (lower respiratory tract infections), urinary tract, skin, bones and joints, abdomen, and bloodstream (septicemia). It also treats bacterial meningitis (infection of the lining around the brain and spinal cord), pelvic inflammatory disease, acute bacterial ear infections (otitis media), and gonorrhea.

In addition, a single dose of ceftriaxone may be given before certain surgeries — such as hysterectomy, gallbladder surgery, or coronary artery bypass surgery — to help prevent postoperative infection. It works only against bacterial infections; it will not treat viral illnesses like the flu or a cold.

Most-Reported Side Effects for Ceftriaxone

From FAERS, the FDA’s public side-effect reporting system (38,242 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 2,054 reports
Acute kidney injury 1,826 reports
Dyspnea 1,592 reports
Pneumonia 1,338 reports
Vomiting 1,265 reports
See full Ceftriaxone Injection drug information
Keep checking

Other Drugs & Skunk Cabbage

Browse every other medication we’ve checked against Skunk Cabbage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Skunk Cabbage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Skunk Cabbage list.

See the full Skunk Cabbage interactions page
See every supplement checked against Ceftriaxone, ranked by severity
Evidence & sources

Skunk Cabbage References

The 4 references that drive our Skunk Cabbage monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Skunk Cabbage and Ceftriaxone Together: Common Questions

Is it safe to take Skunk Cabbage with Ceftriaxone?
We do not list a known interaction between Skunk Cabbage and Ceftriaxone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Skunk Cabbage and Ceftriaxone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Skunk Cabbage in each. That is a conversation for your prescriber, especially if Ceftriaxone is being adjusted to a target.
Does Ceftriaxone interact with any supplements?
Yes. Ceftriaxone has documented interactions with 44 supplements in our database — Skunk Cabbage is not one of them. The Ceftriaxone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Skunk Cabbage monograph Uses, safety profile, and every drug interaction in one place Ceftriaxone Injection drug information The full plain-English guide to this medication Ceftriaxone supplement interactions Every supplement checked against Ceftriaxone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ceftriaxone and Skunk Cabbage?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.