Drug & supplement interaction

Smartweed + Tofacitinib

Tofacitinib brand names: Xeljanz, Xeljanz XR.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Smartweed and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Smartweed and Tofacitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tofacitinib and Smartweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Smartweed safety at a glance

Smartweed overall Use caution There is little modern safety data, so use cautiously and talk to a healthcare provider first.

Pregnancy Avoid Traditionally used to affect menstruation and the uterus, so avoid during pregnancy.

Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tofacitinib and Smartweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tofacitinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tofacitinib is filed under 4 classifications — including cytochrome p450 2c19 (cyp2c19) substrates, immunosuppressants, cytochrome p450 3a4 (cyp3a4) substrates. Smartweed has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Tofacitinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Smartweed Does Interact With Other Medications

Smartweed has 2 moderate known drug interactions in our database — Tofacitinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Tofacitinib)

Taking anything else?

Check Another of Your Medications Against Smartweed

Covers the 2,830 medications we’ve checked against Smartweed. Pick one to open its full report.

What to actually watch for

What Tofacitinib’s Own FDA Label Lists

This is not an interaction — none of it involves Smartweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Tofacitinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

Low blood sugar Worth acting on
Blood clots Worth acting on
A low white blood cell count Worth acting on
Liver problems Worth acting on
A higher chance of infection Worth acting on
An allergic reaction Worth acting on
Joint pain mentioned in 29.0% of FDA reports for Tofacitinib
Headache mentioned in 7.3% of FDA reports for Tofacitinib
Diarrhea
A skin rash

From the ADVERSE REACTIONS section of the FDA label for Tofacitinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 185,980 voluntary FDA FAERS reports for Tofacitinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Smartweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Smartweed side to compare — that is a limit of the record, not a statement that Smartweed has no side effects.

Everything else you take

See Every Supplement That Interacts With Tofacitinib

This page covers Smartweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 143 moderate · 38 minor.

From our pharmacist’s overview on the Tofacitinib page

“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”

Reviewed by 2 · Jul 18, 2026

Open the Tofacitinib interaction page

One more smart check

Taking Smartweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Smartweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Smartweed. Even though Smartweed itself has no known interaction with Tofacitinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Smartweed and Tofacitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Smartweed

Steady interest

#846 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tofacitinib

Top half

#1,277 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Smartweed reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Smartweed and Tofacitinib records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Smartweed

What is Smartweed?

Digestive upset
Minor skin irritation
Heavy menstrual bleeding (traditional)
Wound and bleeding (traditional topical use)
Antioxidant and anti-inflammatory support

Smartweed (Persicaria hydropiper) is a peppery wetland plant with a long history in traditional medicine for digestive complaints, bleeding, and skin problems. Modern human studies are very limited, so its benefits are not well proven. Because safety data are thin, it's best to use cautiously and avoid it during pregnancy and breastfeeding.

Persicaria hydropiper · Polygonaceae · Aerial parts (leaves, stems, and flowering tops); sometimes the whole plant · Tea, tincture, liquid extract, dried herb, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Smartweed is a good idea for someone in your situation. Here is what our Smartweed record says about it on its own.

Smartweed: dosing

There is no well-established or standardized dose for smartweed. Because it has not been carefully studied in people, experts cannot recommend a safe and effective amount.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Smartweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Smartweed monograph & all interactions

Medication

About Tofacitinib

What Is Tofacitinib Used For?

Brand names: Xeljanz, Xeljanz XR

Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults who are unable to take or did not respond to or tolerate one or more TNF inhibitor medication(s). Tofacitinib is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults who are unable to take or who did not respond to one or more TNF inhibitor medication(s). It is also used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years and older who are unable to take or who did not respond to one or more TNF inhibitor medication(s). Tofacitinib is in a class of medications called Janus kinase (JAK) inhibitors. It works by decreasing the activity of the immune system.

See full Tofacitinib drug information

Keep checking

Other Drugs & Smartweed

Browse every other medication we’ve checked against Smartweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

2Moderate

0Minor

2,827No known interaction

2 Moderate 2,827 No interaction

Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Smartweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Smartweed list.

See the full Smartweed interactions page

See every supplement checked against Tofacitinib, ranked by severity

Evidence & sources

Smartweed References

The 2 references that drive our Smartweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Smartweed and Tofacitinib Together: Common Questions

Is it safe to take Smartweed with Tofacitinib?

We do not list a known interaction between Smartweed and Tofacitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Smartweed and Tofacitinib combination checked?

Interactions in our licensed database are recorded against drug classes. Tofacitinib is filed under 4 classifications, and Smartweed has documented interactions with 1 drug class — none of Tofacitinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Smartweed interact with any other medications?

Yes. Smartweed has 2 documented drug interactions in our database — Tofacitinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tofacitinib interact with any supplements?

Yes. Tofacitinib has documented interactions with 184 supplements in our database — Smartweed is not one of them. The Tofacitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Smartweed monograph Uses, safety profile, and every drug interaction in one place Tofacitinib drug information The full plain-English guide to this medication Tofacitinib supplement interactions Every supplement checked against Tofacitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tofacitinib and Smartweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.