Squalamine + Clomipramine
Clomipramine brand names: Anafranil, Anafranil SR.
We found no known interaction between Squalamine and Clomipramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Clomipramine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Squalamine and Clomipramine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Clomipramine and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Clomipramine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Squalamine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Clomipramine Products Have a Food Rule — Squalamine Should Not Break It
At least one FDA label for a product containing Clomipramine says to take it with food. If you take Squalamine on an empty stomach out of habit, keep them separate — and take Clomipramine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Clomipramine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
During initial titration, Anafranil should be given in divided doses with meals to reduce gastrointestinal side effects.
From the Dosage and Administration section of the FDA label we read for Clomipramine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Squalamine or Clomipramine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Squalamine or Clomipramine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Clomipramine
This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clomipramine page lists 236 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and St. John's Wort (major).
By severity: 5 major · 179 moderate · 52 minor.
From our pharmacist’s overview on the Clomipramine page
“A tricyclic antidepressant used mostly for OCD, clomipramine (Anafranil) is unforgiving of shifts in its blood level, which is why its 236 supplement interactions deserve genuine wariness. Most of the list involves metabolism: herbs that speed up or slow down the liver enzymes handling clomipramine can drag its level too low or push it…”
Reviewed by 2 · Jul 18, 2026
Where Squalamine and Clomipramine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#920 of 1,452 supplements looked up here in the last 7 days
#1,782 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Squalamine and Clomipramine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Squalamine
What is Squalamine?
- Cancer (investigational)
- Age-related macular degeneration (eye disease)
- Antimicrobial / antiviral interest
- Anti-angiogenesis (blocking new blood vessel growth)
Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.
Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement
An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.
Squalamine: dosing
There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.
From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.
About Clomipramine
What Is Clomipramine Used For?
Brand names: Anafranil, Anafranil SR
Clomipramine — sold as Anafranil and under the generic name Clomipramine Hydrochloride — is approved to treat obsessions and compulsions in people with Obsessive-Compulsive Disorder (OCD). This includes adults and children/adolescents ages 10 to 17.
To qualify for treatment, the obsessions or compulsions must cause significant distress, take up a lot of time, or noticeably interfere with work, school, or social life.
Other Drugs & Squalamine
Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.
Squalamine References
The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Clomipramine Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Clomipramine as a medicine that can lower these. This is not an interaction with Squalamine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Clomipramine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Squalamine and Clomipramine Together: Common Questions
Is it safe to take Squalamine with Clomipramine?
Do Squalamine and Clomipramine have any of the same side effects?
Should I take Squalamine and Clomipramine at the same time of day?
Does Clomipramine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.