Drug & supplement interaction

Squalamine + Colestipol

Colestipol brand name: Colestid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Colestipol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Colestipol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squalamine and Colestipol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Colestipol and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Colestipol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Colestipol and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Squalamine and Colestipol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite / Vomiting / Nausea Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colestipol

    Listed in the ADVERSE REACTIONS section of the FDA label for Colestipol. Read the label on DailyMed ›

  • Muscle pain Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate myalgias and muscle cramps in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in muscle cramps.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colestipol

    Listed in the ADVERSE REACTIONS section of the FDA label for Colestipol. Read the label on DailyMed ›

  • Tiredness Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colestipol

    Listed in the ADVERSE REACTIONS section of the FDA label for Colestipol. Read the label on DailyMed ›

Reported for Squalamine but not commonly for Colestipol: yellowing of the skin or eyes and liver problems.

Effects for Colestipol come from the ADVERSE REACTIONS section of its FDA label; effects for Squalamine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Colestipol Products Have a Food Rule — Squalamine Should Not Break It

At least one FDA label for a product containing Colestipol says to take it on an empty stomach. Most supplements — Squalamine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Colestipol on its own and move Squalamine to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Colestipol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Patients should take other drugs at least one hour before or four hours after colestipol hydrochloride tablets to minimize possible interference with their absorption.

From the Dosage and Administration section of the FDA label we read for Colestipol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Squalamine or Colestipol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Squalamine or Colestipol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Colestipol

This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Colestipol page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Colestipol page

“Take colestipol (Colestid), a cholesterol drug that works by trapping bile acids in your gut, and nearly every one of the 18 supplement interactions on file comes down to absorption. Only one rates major, activated charcoal, and it belongs at the top of your reading.”

Reviewed by 2 · Jul 18, 2026

Open the Colestipol interaction page

How much people look this up

Where Squalamine and Colestipol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#956 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Colestipol
Top half

#1,038 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Squalamine and Colestipol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Medication

About Colestipol

What Is Colestipol Used For?

Brand name: Colestid

Colestipol — available as oral suspension and tablets under brands including Colestid, Flavored Colestid, and Colestipol Hydrochloride — is used as part of a broader treatment plan (including diet) to lower elevated LDL cholesterol in adults with primary hypercholesterolemia (a condition where LDL cholesterol stays high despite dietary changes).

It is not a standalone fix. Diet, weight management, and other lifestyle changes come first, and colestipol is added when those steps alone aren't enough to reach target LDL levels.

See full Colestipol drug information
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Colestipol, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Colestipol Together: Common Questions

Is it safe to take Squalamine with Colestipol?
We do not list a known interaction between Squalamine and Colestipol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squalamine and Colestipol have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Squalamine and Colestipol at the same time of day?
At least one FDA label for a product containing Colestipol says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Colestipol on its own and move Squalamine to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Colestipol interact with any supplements?
Yes. Colestipol has documented interactions with 18 supplements in our database — Squalamine is not one of them. The Colestipol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Colestipol drug information The full plain-English guide to this medication Colestipol supplement interactions Every supplement checked against Colestipol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Colestipol and Squalamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.