Drug & supplement interaction

Star Of Bethlehem + Fluconazole

Fluconazole brand names: Diflucan, Diflucan Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Star Of Bethlehem and Fluconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Star Of Bethlehem and Fluconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluconazole and Star Of Bethlehem in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Star Of Bethlehem safety at a glance

Star Of Bethlehem overall Use caution The plant and bulb are toxic if eaten; commercial flower essences are very dilute but lack good safety studies.
Pregnancy Likely Unsafe When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluconazole and Star Of Bethlehem? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fluconazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fluconazole is filed under 7 classifications — including antifungals, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Star Of Bethlehem has documented interactions with 7 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Fluconazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Star Of Bethlehem Does Interact With Other Medications

Star Of Bethlehem has 156 moderate known drug interactions in our database — Fluconazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 156 No known interaction 2,674 (incl. Fluconazole)
Taking anything else?

Check Another of Your Medications Against Star Of Bethlehem

Covers the 2,830 medications we’ve checked against Star Of Bethlehem. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Star Of Bethlehem and Fluconazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    Star Of Bethlehem

    “Star of Bethlehem contains cardiac glycosides, which can cause serious adverse effects.

    Serious Adverse Effects (Rare):

    Orally: Star of Bethlehem contains toxic cardiac glycosides that can cause cardiac arrhythmia and death.”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in arrhythmia.

    “Orally, the cardiac glycosides in star of Bethlehem can cause cardiac arrhythmias (2).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in arrhythmia.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Star Of Bethlehem

    “Orally, the cardiac glycosides in star of Bethlehem can cause nausea and vomiting (2).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • Headache Additional detail

    Star Of Bethlehem

    “Orally, the cardiac glycosides in star of Bethlehem can cause headache and stupor (18). Visual color disturbances can also occur (18).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

Effects for Fluconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Star Of Bethlehem come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Star Of Bethlehem in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Star Of Bethlehem or Fluconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Star Of Bethlehem or Fluconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fluconazole

This page covers Star Of Bethlehem only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluconazole page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 54 moderate · 23 minor.

From our pharmacist’s overview on the Fluconazole page

“Fluconazole (Diflucan) treats fungal infections, and I would pair it with supplements carefully. Nearly half of the 81 ingredients with an interaction on file, 38 of them, put extra strain on the liver, which is already busy processing the antifungal.”

Reviewed by 2 · Jul 18, 2026

Open the Fluconazole interaction page

One more smart check

Taking Star Of Bethlehem as Part of a Dietary Supplement Product? Check It for Interactions

We hold 15 real supplement products containing Star Of Bethlehem, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Star Of Bethlehem. Even though Star Of Bethlehem itself has no known interaction with Fluconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Star Of Bethlehem and Fluconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Star Of Bethlehem
Top half

#672 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluconazole
Top 25%

#357 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Star Of Bethlehem reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Star Of Bethlehem and Fluconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Star Of Bethlehem

What is Star Of Bethlehem?

  • Emotional shock and trauma
  • Grief and bereavement
  • Stress relief
  • Calming and comfort

Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional shock and grief. There is no solid scientific evidence that it treats any medical condition, and the raw plant and bulb are considered toxic, so it should not be eaten. If you choose to use a flower-essence product, treat it as a complement to—not a replacement for—proper medical care.

Ornithogalum umbellatum · Asparagaceae · Flowers (used in flower remedies); bulb in some traditional preparations · Flower essence (Bach flower remedy), liquid drops, often part of blends

An interaction check asks whether these two react with each other — it does not ask whether Star Of Bethlehem is a good idea for someone in your situation. Here is what our Star Of Bethlehem record says about it on its own.

Star Of Bethlehem: dosing

There is no established standard dose for Star of Bethlehem, and no medical dosing has been proven safe or effective. Flower-essence products are typically taken as a few drops by mouth or in water, following the directions on the label.If you choose to use a product, follow the manufacturer's instructions and do not exceed them. Never make your own preparation from the wild plant.

From our Star Of Bethlehem monograph — the full record covers uses, side effects and every documented interaction.

Read the full Star Of Bethlehem monograph & all interactions
Medication

About Fluconazole

What Is Fluconazole Used For?

Brand names: Diflucan, Diflucan Injection

Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Most-Reported Side Effects for Fluconazole

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,205 reports
Nausea 3,813 reports
Diarrhea 3,614 reports
Fatigue 3,266 reports
Headache 2,930 reports
See full Fluconazole drug information
Keep checking

Other Drugs & Star Of Bethlehem

Browse every other medication we’ve checked against Star Of Bethlehem — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
156Moderate
0Minor
2,673No known interaction
156 Moderate 2,673 No interaction
Moderate

156 interactions

Showing 60 of 156 moderate interactions — see all 156 on the Star Of Bethlehem page.

No interaction 2,673 drugs checked — show the list

We also checked Star Of Bethlehem against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Star Of Bethlehem list.

See the full Star Of Bethlehem interactions page
See every supplement checked against Fluconazole, ranked by severity
Evidence & sources

Star Of Bethlehem References

The 8 references that drive our Star Of Bethlehem monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  6. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
  7. Vogelsang A. Clinical trial of Ornithogalum umbellatum on the human heart; preliminary report. Can Med Assoc J 1955;73:295-6.
  8. Smith JA, Paterson GR. Rhodexin A and rhodexoside in Ornithogalum umbellatum. J Pharm Pharmacol 1967;19:221-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Star Of Bethlehem and Fluconazole Together: Common Questions

Is it safe to take Star Of Bethlehem with Fluconazole?
We do not list a known interaction between Star Of Bethlehem and Fluconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Star Of Bethlehem and Fluconazole have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Star Of Bethlehem and Fluconazole combination checked?
Interactions in our licensed database are recorded against drug classes. Fluconazole is filed under 7 classifications, and Star Of Bethlehem has documented interactions with 7 drug classes — none of Fluconazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Star Of Bethlehem interact with any other medications?
Yes. Star Of Bethlehem has 156 documented drug interactions in our database — Fluconazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fluconazole interact with any supplements?
Yes. Fluconazole has documented interactions with 81 supplements in our database — Star Of Bethlehem is not one of them. The Fluconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Star Of Bethlehem monograph Uses, safety profile, and every drug interaction in one place Fluconazole drug information The full plain-English guide to this medication Fluconazole supplement interactions Every supplement checked against Fluconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fluconazole and Star Of Bethlehem?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.