Drug & supplement interaction

Tangerine + Trastuzumab

Trastuzumab brand name: Herceptin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tangerine and Trastuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Tangerine and Trastuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trastuzumab and Tangerine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tangerine safety at a glance

Tangerine overall Generally safe Tangerine fruit is generally safe when eaten as food.
Pregnancy Use caution The fruit is fine as food, but concentrated extracts and essential oil should be used with caution and medical advice.
Breastfeeding Use caution Eating the fruit is fine, but safety of concentrated supplements or oils is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trastuzumab and Tangerine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Tangerine Does Interact With Other Medications

Tangerine has 643 minor known drug interactions in our database — Trastuzumab isn’t one of them. If you take anything else, check it against the full list below.

Minor 643 No known interaction 2,187 (incl. Trastuzumab)
Taking anything else?

Check Another of Your Medications Against Tangerine

Covers the 2,830 medications we’ve checked against Tangerine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tangerine and Trastuzumab May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Tangerine

    “Orally, very few adverse effects have been reported with the medicinal use of tangerine. However, a thorough evaluation of safety outcomes has not been conducted.

    Topically, contact dermatitis has been associated with tangerine essential oil.”

    Tangerine · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 28610. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

    “According to one case report, the essential oil of tangerine in a fragrance has been associated with contact dermatitis.”

    Tangerine · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 28610. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

    Trastuzumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab. Read the label on DailyMed ›

Effects for Trastuzumab come from the ADVERSE REACTIONS section of its FDA label; effects for Tangerine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 86,493 voluntary FDA FAERS reports for Trastuzumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Trastuzumab Is Prescribed For, and What Tangerine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Trastuzumab is a prescription medicine with approved uses on its FDA label. Tangerine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Trastuzumab is prescribed for: Trastuzumab injection is used in adults to treat certain cancers that overexpress the HER2 protein. For breast cancer, it is used as adjuvant (after-surgery) treatment for early-stage HER2-positive breast cancer, in combination with certain chemotherapy regimens, as well as for metastatic (spread) HER2-positive breast cancer — either with paclitaxel as a first-line treatment or as a single agent after prior chemotherapy. Ontruzant is also indicated in adults for treatment of HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma (a type of stomach or esophageal junction cancer), in combination with cisplatin and capecitabine or 5-fluorouracil, for patients who have not received prior treatment for metastatic disease. Patients must be selected based on FDA-approved HER2 testing before starting therapy.

Tangerine has been studied for:

  • Cancer studied, not established Tangerine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Tangerine for cancer

    Observational research has found that daily intake of oranges and/or tangerines is associated with a reduced odds of developing nasopharyngeal carcinoma when compared with consuming oranges and/or tangerines less than once a week.

    1 source cited
    1. 28608. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Trastuzumab on your own; if you are taking Tangerine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Tangerine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 705 real supplement products containing Tangerine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tangerine. Even though Tangerine itself has no known interaction with Trastuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tangerine and Trastuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tangerine
Top 25%

#257 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trastuzumab
Top half

#1,275 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tangerine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tangerine and Trastuzumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tangerine

What is Tangerine?

  • Source of vitamin C
  • Digestive support
  • Aromatherapy and relaxation
  • Cough and phlegm (traditional)
  • Skin and flavoring uses

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and aromatherapy, strong human evidence for specific health benefits beyond basic nutrition is limited. Enjoying tangerines as part of a balanced diet is generally safe for most people.

Citrus reticulata · Rutaceae · Fruit, peel, and essential oil · Fresh fruit, juice, dried peel, essential oil, capsules, extracts

An interaction check asks whether these two react with each other — it does not ask whether Tangerine is a good idea for someone in your situation. Here is what our Tangerine record says about it on its own.

Tangerine: dosing

There is no official or standardized medicinal dose for tangerine. As a food, you can simply enjoy it the way you would any fruit.For peel, extracts, essential oil, or capsule products, there is no established dose proven safe and effective for any condition. Essential oils are for external or aromatherapy use only unless a professional advises otherwise.

From our Tangerine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tangerine monograph & all interactions
Medication

About Trastuzumab Injection

What Is Trastuzumab Injection Used For?

Brand name: Herceptin

Trastuzumab injection is used in adults to treat certain cancers that overexpress the HER2 protein. For breast cancer, it is used as adjuvant (after-surgery) treatment for early-stage HER2-positive breast cancer, in combination with certain chemotherapy regimens, as well as for metastatic (spread) HER2-positive breast cancer — either with paclitaxel as a first-line treatment or as a single agent after prior chemotherapy.

Ontruzant is also indicated in adults for treatment of HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma (a type of stomach or esophageal junction cancer), in combination with cisplatin and capecitabine or 5-fluorouracil, for patients who have not received prior treatment for metastatic disease. Patients must be selected based on FDA-approved HER2 testing before starting therapy.

Most-Reported Side Effects for Trastuzumab

From FAERS, the FDA’s public side-effect reporting system (88,598 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 7,825 reports
Nausea 6,098 reports
Fatigue 5,551 reports
Alopecia 5,432 reports
Disease progression 4,960 reports
See full Trastuzumab Injection drug information
Keep checking

Other Drugs & Tangerine

Browse every other medication we’ve checked against Tangerine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
643Minor
2,186No known interaction
643 Minor 2,186 No interaction
Minor

643 interactions

Showing 60 of 643 minor interactions — see all 643 on the Tangerine page.

No interaction 2,186 drugs checked — show the list

We also checked Tangerine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Tangerine list.

See the full Tangerine interactions page
See every supplement checked against Trastuzumab, ranked by severity
Evidence & sources

Tangerine References

The 3 references that drive our Tangerine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tangerine and Trastuzumab Together: Common Questions

Is it safe to take Tangerine with Trastuzumab?
We do not list a known interaction between Tangerine and Trastuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tangerine and Trastuzumab have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Tangerine and Trastuzumab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Tangerine in each. That is a conversation for your prescriber, especially if Trastuzumab is being adjusted to a target.
Does Tangerine interact with any other medications?
Yes. Tangerine has 643 documented drug interactions in our database — Trastuzumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tangerine monograph Uses, safety profile, and every drug interaction in one place Trastuzumab Injection drug information The full plain-English guide to this medication Trastuzumab supplement interactions Every supplement checked against Trastuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trastuzumab and Tangerine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.