Drug & supplement interaction

Tonka Bean + Diclofenac

Diclofenac brand name: Zorvolex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tonka Bean and Diclofenac in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tonka Bean and Diclofenac

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac and Tonka Bean in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tonka Bean at all — not against Diclofenac, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tonka Bean safety at a glance

Tonka Bean overall Use caution Tonka bean is high in coumarin, which can harm the liver in larger amounts, and it is restricted as a food additive in many countries.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac and Tonka Bean? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tonka Bean and Diclofenac May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Tonka Bean

    “Orally, tonka bean may be unsafe.

    Most Common Adverse Effects:

    Orally: Diarrhea, dizziness, insomnia, nausea, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Liver toxicity, paralysis of the heart.”

    Tonka Bean · Natural Medicines adverse-effect record, reported in diarrhea.

    Diclofenac

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac. Read the label on DailyMed ›

  • Trouble sleeping / Dizziness Additional detail

    Tonka Bean

    “Orally, coumarin, a constituent of tonka bean, has been associated with dizziness and insomnia.”

    Tonka Bean · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 287. Marshall ME, Butler K, Fried A. Phase I evaluation of coumarin (1,2 benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 1991;3:170-8.

    Diclofenac

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac. Read the label on DailyMed ›

  • Nausea / Diarrhea / Vomiting reported in 6.1% of FDA reports for Diclofenac Additional detail

    Tonka Bean

    “Orally, coumarin, a constituent of tonka bean, has been associated with nausea, vomiting, and diarrhea.”

    Tonka Bean · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 286. Mohler JL, Gomella LG, Crawford ED, et al. Phase II evaluation of coumarin (1,2-benzopyrone) in metastatic prostatic carcinoma. Prostate 1992;20:123-31. PubMed
    2. 287. Marshall ME, Butler K, Fried A. Phase I evaluation of coumarin (1,2 benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 1991;3:170-8.

    Diclofenac

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Diclofenac come from the ADVERSE REACTIONS section of its FDA label; effects for Tonka Bean come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 164,880 voluntary FDA FAERS reports for Diclofenac that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tonka Bean in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Tonka Bean or Diclofenac

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tonka Bean or Diclofenac, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac

This page covers Tonka Bean only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac page lists 306 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 265 moderate · 34 minor.

From our pharmacist’s overview on the Diclofenac page

“Diclofenac (Zorvolex) is an NSAID pain reliever that already stresses the stomach lining and kidneys on its own, so treat this list as a real safety issue, not fine print. Two thirds of the 306 supplements on file can thin the blood or slow clotting, and stacked on an NSAID that raises the odds of stomach bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac interaction page

One more smart check

Taking Tonka Bean as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Tonka Bean, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tonka Bean. Even though Tonka Bean itself has no known interaction with Diclofenac, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tonka Bean and Diclofenac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tonka Bean
Steady interest

#778 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac
Top 25%

#370 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tonka Bean reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tonka Bean and Diclofenac records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tonka Bean

What is Tonka Bean?

  • Flavoring in food and desserts
  • Fragrance and perfume
  • Cough and sore throat (traditional)
  • Digestive complaints (traditional)
  • Relaxation

Tonka bean comes from the seed of a South American tree and is prized for its sweet, vanilla-like aroma in perfumes and cooking. It contains coumarin, which can be toxic to the liver and is restricted in food in many countries, so it is not recommended as a health supplement. There is no reliable evidence that it treats any medical condition.

Dipteryx odorata · Fabaceae · Seeds (beans) and the extract or essential oil · Whole or grated bean, extract/flavoring, essential oil, perfume ingredient

An interaction check asks whether these two react with each other — it does not ask whether Tonka Bean is a good idea for someone in your situation. Here is what our Tonka Bean record says about it on its own.

Tonka Bean: dosing

There is no established safe or effective medicinal dose for tonka bean, and it is not recommended as a supplement. In cooking, chefs use only a tiny shaving of the bean because of its strong flavor and coumarin content.If you come across a product containing tonka bean, follow the product label and keep amounts very small.

From our Tonka Bean monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tonka Bean monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand name: Zorvolex

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac

From FAERS, the FDA’s public side-effect reporting system (164,880 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,336 reports
Arthralgia 11,682 reports
Rash 11,262 reports
Rheumatoid arthritis 11,000 reports
Nausea 10,099 reports
See full Diclofenac drug information
Keep checking

Other Drugs & Tonka Bean

Browse every other medication we’ve checked against Tonka Bean — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tonka Bean against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tonka Bean list.

See the full Tonka Bean interactions page
See every supplement checked against Diclofenac, ranked by severity
Evidence & sources

Tonka Bean References

The 4 references that drive our Tonka Bean monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Mohler JL, Gomella LG, Crawford ED, et al. Phase II evaluation of coumarin (1,2-benzopyrone) in metastatic prostatic carcinoma. Prostate 1992;20:123-31. PubMed
  3. Marshall ME, Butler K, Fried A. Phase I evaluation of coumarin (1,2 benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 1991;3:170-8.
  4. Cox D, O'Kennedy R, Thornes RD. The rarity of toxicity in patients treated with coumarin (1,2-benzopyrone). Hum Toxicol 1989;8:501-6.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tonka Bean and Diclofenac Together: Common Questions

Is it safe to take Tonka Bean with Diclofenac?
We do not list a known interaction between Tonka Bean and Diclofenac. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tonka Bean and Diclofenac have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Diclofenac interact with any supplements?
Yes. Diclofenac has documented interactions with 306 supplements in our database — Tonka Bean is not one of them. The Diclofenac interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tonka Bean monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac supplement interactions Every supplement checked against Diclofenac, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac and Tonka Bean?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.