Transfer Factor + Pregabalin
Pregabalin brand names: Lyrica, Lyrica CR.
We found no known interaction between Transfer Factor and Pregabalin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Transfer Factor and Pregabalin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pregabalin and Transfer Factor in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Transfer Factor at all — not against Pregabalin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Transfer Factor safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Questions About Transfer Factor or Pregabalin
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Transfer Factor or Pregabalin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Lyrica And Flexeril Together? ›
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Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Pregabalin
This page covers Transfer Factor only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pregabalin page lists 95 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 73 moderate · 15 minor.
From our pharmacist’s overview on the Pregabalin page
“Pregabalin (Lyrica) calms overactive nerves, which is how it eases nerve pain, seizures, and anxiety, and that calming action stacks with almost everything on this list. Of the 95 supplements and herbs, the large majority add their own sedation on top of pregabalin's, and a few can tip that into genuine danger, with deep sedation and s…”
Reviewed by 2 · Jul 18, 2026
Where Transfer Factor and Pregabalin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#752 of 1,452 supplements looked up here in the last 7 days
#40 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Transfer Factor reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Transfer Factor and Pregabalin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Transfer Factor
What is Transfer Factor?
- Immune support
- Preventing colds and infections
- Allergies
- General wellness
- Chronic viral conditions
Transfer factors are small immune molecules taken from cow colostrum or egg yolk and sold as supplements meant to boost or 'train' the immune system. Solid human evidence for the supplement products is limited, and quality varies widely between brands. Talk with your pharmacist or doctor before using one, especially if you have an immune condition.
Small immune molecules (peptides) extracted from sources such as cow colostrum or hen egg yolk · Capsules, tablets, powders
An interaction check asks whether these two react with each other — it does not ask whether Transfer Factor is a good idea for someone in your situation. Here is what our Transfer Factor record says about it on its own.
Transfer Factor: dosing
There is no official or standardized dose for transfer factor supplements. Because products differ in how they are made and how concentrated they are, the right amount is hard to define.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide if a product is appropriate and reasonable.
From our Transfer Factor monograph — the full record covers uses, side effects and every documented interaction.
About Pregabalin
What Is Pregabalin Used For?
Brand names: Lyrica, Lyrica CR
Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury.
Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.
Most-Reported Side Effects for Pregabalin
From FAERS, the FDA’s public side-effect reporting system (270,557 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Transfer Factor
Browse every other medication we’ve checked against Transfer Factor — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Transfer Factor against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Transfer Factor list.
Transfer Factor References
The 49 references that drive our Transfer Factor monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Jones JF, Minnich LL, Jeter WS, et al. Treatment of childhood combined Epstein-Barr virus/cytomegalovirus infection with oral bovine transfer factor. Lancet 1981;2:122-4. PubMed
- Steele RW, Myers MG, Vincent MM. Transfer factor for the prevention of varicella-zoster infection in childhood leukemia. N Engl J Med 1980;303:355-9. PubMed
- Louie E, Borkowsky W, Klesius PH, et al. Treatment of cryptosporidiosis with oral bovine transfer factor. Clin Immunol Immunopathol 1987;44:329-34. PubMed
- McMeeking A, Borkowsky W, Klesius PH, et al. A controlled trial of bovine dialyzable leukocyte extract for cryptosporidiosis in patients with AIDS. J Infect Dis 1990;161:108-12. PubMed
- Fudenberg HH. Transfer factor: past, present and future. Annu Rev Pharmacol Toxicol 1989;29:475-516. PubMed
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Miller LL, Spitler LE, Allen RE, Minor DR. A randomized, double-blind, placebo-controlled trial of transfer factor as adjuvant therapy for malignant melanoma. Cancer 1988;61:1543-9. PubMed
- Bukowski RM, Deodhar S, Hewlett JS, Greenstreet R. Randomized controlled trial of transfer factor in Stage II malignant melanoma. Cancer 1983;51:269-72. PubMed
- Bowden RA, Siegel MS, Steele RW, et al. Immunologic and clinical responses to varicella-zoster virus-specific transfer factor following marrow ransplantation. J Infect Dis 1985;152:1324-7.
- Sharma MK, Anaraki F, Ala F. Preliminary results of transfer factor therapy of persistant cutaneous leishmania infection. Clin Immunol Immunopathol 1979;12:183-90. PubMed
- Whyte RI, Schork MA, Sloan H, et al. Adjuvant treatment using transfer factor for bronchogenic carcinoma: long-term follow-up. Ann Thorac Surg 1992;53:391-6. PubMed
- Lloyd AR, Hickie I, Brockman A, et al. Immunologic and psychologic therapy for patients with chronic fatigue syndrome: a double-blind, placebo-controlled trial. Am J Med 1993;94:197-203. PubMed
- Spitler LE. Transfer factor therapy in the Wiskott-Aldrich syndrome. Results of long-term follow-up in 32 patients. Am J Med 1979;67:59-66.
- Roda E, Viza D, Pizza G, et al. Transfer factor for the treatment of HBsAg-positive chronic active hepatitis. Proc Soc Exp Biol Med 1985;178:468-75. PubMed
- Basten A, McLeod JG, Pollard JD, et al. Transfer factor in treatment of multiple sclerosis. Lancet 1980;2:931-4. PubMed
- Fog T, Pedersen L, Raun NE, et al. Long-term transfer-factor treatment for multiple sclerosis. Lancet 1978;1:851-3. PubMed
- Fujisawa T, Yamaguchi Y, Kimura H, et al. Adjuvant immunotherapy of primary resected lung cancer with transfer factor. Cancer 1984;54:663-9. PubMed
- Delgado O, Romano EL, Belfort E, et al. Dialyzable leukocyte extract therapy in immunodepressed patients with cutaneous leishmaniasis. Clin Immunol Immunopathol 1981;19:351-9. PubMed
- Stevens, D. A., Ferrington, R. A., Merigan, T. C., and Marinkovich, V. A. Randomized trial of transfer factor treatment of human warts. Clin.Exp.Immunol. 1975;21(3):520-524.
- Iseki, M., Aoyama, T., Koizumi, Y., Ojima, T., Murase, Y., and Osano, M. [Effects of transfer factor on chronic hepatitis B in childhood]. Kansenshogaku Zasshi 1989;63(12):1329-1332. PubMed
- Corrado, F., Pizza, G., De, Vinci C., and Corrado, G. [Immunotherapy with transfer factor in hormone-resistant metastasized carcinoma of the prostate]. Arch.Esp.Urol. 1989;42 Suppl 2:191-196.
- No author. Interferon-alpha and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trial. AUSTIMS Research Group. J.Neurol.Neurosurg.Psychiatry 1989;52(5):566-574. PubMed
- Ashorn, R., Uotila, A., Kuokkanen, K., Rasanen, L., Karhumaki, E., and Krohn, K. Cellular immunity in acne vulgaris during transfer factor treatment. Ann.Clin.Res. 1985;17(4):152-155.
- Goldenberg, G. J., Brandes, L. J., Lau, W. H., Miller, A. B., Wall, C., and Ho, J. H. Cooperative trial of immunotherapy for nasopharyngeal carcinoma with transfer factor from donors with Epstein-Barr virus antibody activity. Cancer Treat.Rep. 1985;69(7-
- Hancock, B. W., Bruce, L., Sokol, R. J., and Clark, A. Transfer factor in Hodgkin's disease: a randomized clinical and immunological study. Eur.J.Cancer Clin.Oncol. 1988;24(5):929-933. PubMed
- Miller, L. L., Spitler, L. E., Allen, R. E., and Minor, D. R. A randomized, double-blind, placebo-controlled trial of transfer factor as adjuvant therapy for malignant melanoma. Cancer 4-15-1988;61(8):1543-1549. PubMed
- Wagner, G., Knapp, W., Gitsch, E., and Selander, S. Transfer factor for adjuvant immunotherapy in cervical cancer. Cancer Detect.Prev.Suppl 1987;1:373-376.
- Gilchrist, G. S., Ivins, J. C., Ritts, R. E., Jr., Pritchard, D. J., Taylor, W. F., and Edmonson, J. M. Adjuvant therapy for nonmetastatic osteogenic sarcoma: an evaluation of transfer factor versus combination chemotherapy. Cancer Treat.Rep. 1978;62(2):
- Hoyeraal, H. M., Froland, S. S., Salvesen, C. F., Munthe, E., Natvig, J. B., Kass, E., Blichfeldt, P., Hegna, T. M., Revlem, E., Sandstad, B., and Hjort, N. L. No effect of transfer factor in juvenile rheumatoid arthritis by double-blind trial. Ann.Rheum
- Vicary, F. R., Chambers, J. D., and Dhillon, P. Double-blind trial of the use of transfer factor in the treatment of Crohn's disease. Gut 1979;20(5):408-413. PubMed
- Ashorn, R. G., Rasanen, L., Marnela, K. M., and Krohn, K. J. Human transfer factor in vitro. II. Augmentation of the secretion of leucocyte migration inhibitory factor (LIF) by leucocyte dialysate and by its components L-serine and glycine. Clin.Exp.Immu
- Olarte, M. R., Gersten, J. C., Zabriskie, J., and Rowland, L. P. Transfer factor is ineffective in amyotrophic lateral sclerosis. Ann.Neurol. 1979;5(4):385-388. PubMed
- Shulman, S. T., Hutto, J. H., Jr., Ayoub, E. M., Howlett, S. A., Scott, B., and McGuigan, J. E. A double-blind evaluation of transfer factor therapy of HBsAg-positive chronic aggressive hepatitis: preliminary report of efficacy. Cell Immunol. 3-15-1979;4 PubMed
- Ellis-Pegler, R., Sutherland, D. C., Douglas, R., Woodfield, D. G., and Wilson, J. D. Transfer factor and hepatitis B: a double blind study. Clin.Exp.Immunol. 1979;36(2):221-226.
- Thestrup-Pedersen, K., Grunnet, E., and Zachariae, H. Transfer factor therapy in mycosis fungoides: a double-blind study. Acta Derm.Venereol. 1982;62(1):47-53. DOI
- Fujisawa, T., Yamaguchi, Y., Kimura, H., Arita, M., Shiba, M., and Baba, M. Randomized controlled trial of transfer factor immunochemotherapy as an adjunct to surgical treatment for primary adenocarcinoma of the lung. Jpn.J.Surg. 1984;14(6):452-458. PubMed
- Lamoureux, G., Cosgrove, J., Duquette, P., Lapierre, Y., Jolicoeur, R., and Vanderland, F. A clinical and immunological study of the effects of transfer factor on multiple sclerosis patients. Clin.Exp.Immunol. 1981;43(3):557-564.
- Pizza, G., Meduri, R., De, Vinci C., Scorolli, L., and Viza, D. Transfer factor prevents relapses in herpes keratitis patients: a pilot study. Biotherapy 1994;8(1):63-68. PubMed
- Fernandez, O., Diaz, N., Morales, E., Toledo, J., Hernandez, E., Rojas, S., Madriz, X., and Lopez, Saura P. Effect of transfer factor on myelosuppression and related morbidity induced by chemotherapy in acute leukaemias. Br.J.Haematol. 1993;84(3):423-427 PubMed
- Raise, E., Guerra, L., Viza, D., Pizza, G., De, Vinci C., Schiattone, M. L., Rocaccio, L., Cicognani, M., and Gritti, F. Preliminary results in HIV-1-infected patients treated with transfer factor (TF) and zidovudine (ZDV). Biotherapy 1996;9(1-3):49-54. PubMed
- Meduri, R., Campos, E., Scorolli, L., De, Vinci C., Pizza, G., and Viza, D. Efficacy of transfer factor in treating patients with recurrent ocular herpes infections. Biotherapy 1996;9(1-3):61-66. PubMed
- Pizza, G., Viza, D., De, Vinci C., Palareti, A., Cuzzocrea, D., Fornarola, V., and Baricordi, R. Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses. Biotherapy 1996;9(1-3):67-72. PubMed
- Byston, J., Cech, K., Pekarek, J., and Jilkova, J. Effect of anti-herpes specific transfer factor. Biotherapy 1996;9(1-3):73-75. PubMed
- De Vinci, C., Levine, P. H., Pizza, G., Fudenberg, H. H., Orens, P., Pearson, G., and Viza, D. Lessons from a pilot study of transfer factor in chronic fatigue syndrome. Biotherapy 1996;9(1-3):87-90. PubMed
- Prasad, U., bin Jalaludin, M. A., Rajadurai, P., Pizza, G., De, Vinci C., Viza, D., and Levine, P. H. Transfer factor with anti-EBV activity as an adjuvant therapy for nasopharyngeal carcinoma: a pilot study. Biotherapy 1996;9(1-3):109-115. PubMed
- Pilotti, V., Mastrorilli, M., Pizza, G., De, Vinci C., Busutti, L., Palareti, A., Gozzetti, G., and Cavallari, A. Transfer factor as an adjuvant to non-small cell lung cancer (NSCLC) therapy. Biotherapy 1996;9(1-3):117-121. PubMed
- Pizza, G., De, Vinci C., Cuzzocrea, D., Menniti, D., Aiello, E., Maver, P., Corrado, G., Romagnoli, P., Dragoni, E., LoConte, G., Riolo, U., Palareti, A., Zucchelli, P., Fornarola, V., and Viza, D. A preliminary report on the use of transfer factor for t
- Acosta-Rios MP, Sauer-Ramírez E, Castro-Muñoz LJ, et al. Effect of dialyzable leukocyte extract on chronic cervicitis in patients with HPV infection. J Med Life. 2017;10(4):237-243.
- Rodriguez-Flores A, Nuñez-Fernandez G, Estrada-Garcia I, et al. Adjuvant treatment with a dialyzable leukocytes extract contributes to maintain HPV-infected women free of low-grade cervical lesions. Eur J Gynaecol Oncol. 2015;36(6):655-61.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Transfer Factor and Pregabalin Together: Common Questions
Is it safe to take Transfer Factor with Pregabalin?
Do Transfer Factor and Pregabalin have any of the same side effects?
Does Pregabalin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Pregabalin and Transfer Factor?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.