Tribulus - Paxil (Paroxetine) Interaction
Herbal: Tribulus
Also Known As: Tribulus terrestris, Abrojo, Abrojos, Al-Gutub, Baijili, Bindii, Bulgarian Tribulus Terrestris, Caltrop, Cat's-Head, Ci Ji Li, Common Dubbletjie, Croix-de-Malte, Devil's-Thorn, Devil's-Weed, Épine du Diable, Escarbot, Espigón, German Tribulus Terrestris, Goathead, Gokantaka
Drug: Paroxetine
Brand names:
Paxil CR, Paxil, Brisdelle
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 08, 2025
Interaction Details
There were no interactions found between Paroxetine and Tribulus. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Tribulus Overview
Tribulus is a plant that belongs to the Zygophyllaceae family. It is native to a variety of warm and tropical regions of the world, including Africa, Asia, Europe, and Australia. The plant is known for its spiky, star-shaped flowers and hairy fruit, which contains small, hard seeds.
Tribulus is often utilized as an ingredient in dietary supplements and is one of the most commonly used natural medicines in the world. Its most well-known use is as an aphrodisiac, with a purported ability to improve libido and sexual function. It has also been used to boost athletic performance, and reduce inflammation.
Most often, it is the leaf, fruit, and root of Tribulus that are used as natural medicine. They contain a number of compounds, including protodioscin, which may influence certain hormones, such as testosterone and dehydroepiandrosterone.
Paroxetine Overview
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Paroxetine tablets, suspension (liquid), and extended-release (long-acting) tablets are used to treat depression, panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). Paroxetine tablets and suspension are also used to treat obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), generalized anxiety disorder (GAD; excessive worrying that is difficult to control), and posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience). Paroxetine extended-release tablets are also used to treat premenstrual dysphoric disorder (PMDD, physical and psychological symptoms that occur before the onset of the menstrual period each month). Paroxetine capsules (Brisdelle) are used to treat hot flashes (sudden feelings of warmth, especially in the face, neck, and chest) in women who are experiencing menopause (stage of life when menstrual periods become less frequent and stop and women may experience other symptoms and body changes). Paroxetine is in a class of medications called selective serotonin-reuptake inhibitors (SSRIs). It treats depression and other mental illnesses by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. There is not enough information available at this time to know how paroxetine works to treat hot flashes.
Tribulus - More Interactions
Tribulus interacts with 254 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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