Drug & supplement interaction

Wallflower + Guaifenesin

Guaifenesin brand names: Robitussin, Humibid LA, Amibid LA, Numobid, Muco-Fen 800, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wallflower and Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Wallflower and Guaifenesin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Guaifenesin and Wallflower in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wallflower safety at a glance

Wallflower overall Use caution The plant contains heart-active glycosides that can be toxic, and human safety data are very limited.
Pregnancy Possibly Unsafe When used orally due to its cardiac glycoside content and possible toxic effects; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally due to its cardiac glycoside content and possible toxic effects; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Guaifenesin and Wallflower? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Guaifenesin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Guaifenesin is filed under 2 classifications — including oral drugs. Wallflower has documented interactions with 6 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Guaifenesin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wallflower Does Interact With Other Medications

Wallflower has 123 moderate known drug interactions in our database — Guaifenesin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 123 No known interaction 2,707 (incl. Guaifenesin)
Taking anything else?

Check Another of Your Medications Against Wallflower

Covers the 2,830 medications we’ve checked against Wallflower. Pick one to open its full report.

Special populations

Wallflower in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally due to its cardiac glycoside content and possible toxic effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Wallflower or Guaifenesin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wallflower or Guaifenesin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Guaifenesin

This page covers Wallflower only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guaifenesin page lists 26 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Berberine (moderate), Bitter Orange (moderate) and Coffee Charcoal (moderate).

By severity: 2 major · 15 moderate · 9 minor.

From our pharmacist’s overview on the Guaifenesin page

“Guaifenesin (Robitussin, Humibid LA) loosens chest mucus, and by itself it is a mild medicine, but two of the 26 supplements on this list rate major, so those two deserve your attention first. Activated charcoal can bind the drug in your gut and blunt what it does, and grapefruit raises blood levels of dextromethorphan, the cough suppr…”

Reviewed by 2 · Jul 18, 2026

Open the Guaifenesin interaction page

How much people look this up

Where Wallflower and Guaifenesin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wallflower
Top half

#703 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guaifenesin
Steady interest

#1,701 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wallflower reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wallflower and Guaifenesin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wallflower

What is Wallflower?

  • Heart-related folk tonic
  • Nervous tension
  • Joint and muscle aches (topical)
  • Menstrual complaints
  • As an ornamental and fragrance plant

Wallflower (Erysimum cheiri) is a fragrant garden plant with a long history in traditional medicine, but there is very little modern human research to support any health use. It contains cardiac glycoside-type compounds that can be toxic, so it should not be taken internally without professional guidance, and it should be avoided during pregnancy and breastfeeding.

Erysimum cheiri · Brassicaceae · Flowers, leaves, seeds, and aerial parts · Dried herb, tincture, infusion (tea), and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Wallflower is a good idea for someone in your situation. Here is what our Wallflower record says about it on its own.

Wallflower: dosing

There is no established or standardized dose for wallflower. It is not a mainstream supplement, and reliable dosing information from clinical research does not exist.If you come across a product that contains wallflower, follow the label exactly and do not exceed the suggested amount.

From our Wallflower monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wallflower monograph & all interactions
Medication

About Guaifenesin

What Is Guaifenesin Used For?

Brand names: Robitussin, Humibid LA, Amibid LA, Numobid, Muco-Fen 800, Bidex, Organidin, X-pect, Mucinex

Guaifenesin helps loosen phlegm (mucus) and thin bronchial secretions — the sticky fluid in your airways — so your cough can clear it out more effectively. It is used to relieve chest congestion associated with colds, respiratory infections, and other conditions that cause a mucus-filled cough.

This use is supported across multiple products including tablets, extended-release tablets, and oral solutions such as Childrens Mucus Relief, Tussin, Guaifenesin STRAWBERRY-BANANA FLAVOR, 12 Hour Mucus Relief, 365 Whole Foods Market Guaifenesin, Dr. Simi Mucus Relief, and others.

See full Guaifenesin drug information
Keep checking

Other Drugs & Wallflower

Browse every other medication we’ve checked against Wallflower — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
123Moderate
0Minor
2,706No known interaction
123 Moderate 2,706 No interaction
Moderate

123 interactions

Showing 60 of 123 moderate interactions — see all 123 on the Wallflower page.

No interaction 2,706 drugs checked — show the list

We also checked Wallflower against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,706 medications checked with no known interaction — see the full Wallflower list.

See the full Wallflower interactions page
See every supplement checked against Guaifenesin, ranked by severity
Evidence & sources

Wallflower References

The 4 references that drive our Wallflower monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wallflower and Guaifenesin Together: Common Questions

Is it safe to take Wallflower with Guaifenesin?
We do not list a known interaction between Wallflower and Guaifenesin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Wallflower and Guaifenesin combination checked?
Interactions in our licensed database are recorded against drug classes. Guaifenesin is filed under 2 classifications, and Wallflower has documented interactions with 6 drug classes — none of Guaifenesin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wallflower interact with any other medications?
Yes. Wallflower has 123 documented drug interactions in our database — Guaifenesin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Guaifenesin interact with any supplements?
Yes. Guaifenesin has documented interactions with 26 supplements in our database — Wallflower is not one of them. The Guaifenesin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wallflower monograph Uses, safety profile, and every drug interaction in one place Guaifenesin drug information The full plain-English guide to this medication Guaifenesin supplement interactions Every supplement checked against Guaifenesin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Guaifenesin and Wallflower?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.