Drug & supplement interaction

White Pepper + Crofelemer

Crofelemer brand names: Fulyzaq, Mytesi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between White Pepper and Crofelemer in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

White Pepper and Crofelemer

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crofelemer and White Pepper in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

White Pepper safety at a glance

White Pepper overall Generally safe Generally safe in the small amounts used to flavor food.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of topical white pepper or white pep... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of white pepper when used in medicina... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crofelemer and White Pepper? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Crofelemer

Interactions in our licensed database are recorded against drug classes, not just single drug names. Crofelemer is filed under a single classification — oral drugs. White Pepper has documented interactions with 16 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cyclosporine (neoral, sandimmune) (moderate) — and none of Crofelemer’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

White Pepper Does Interact With Other Medications

White Pepper has 976 moderate, 3 minor known drug interactions in our database — Crofelemer isn’t one of them. If you take anything else, check it against the full list below.

Moderate 976 Minor 3 No known interaction 1,851 (incl. Crofelemer)
Taking anything else?

Check Another of Your Medications Against White Pepper

Covers the 2,830 medications we’ve checked against White Pepper. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests White Pepper and Crofelemer May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    White Pepper

    “Orally, white pepper can cause a burning aftertaste and irritation to the throat and anterior tongue. Single and repeated application of piperine, a constituent of white pepper, increased irritation of the tongue and oral cavity, resulting in decreased taste.”

    White Pepper · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 29268. Rentmeister-Bryant, H. and Green, B. G. Perceived irritation during ingestion of capsaicin or piperine: comparison of trigeminal and non-trigeminal areas. Chem.Senses 1997;22(3):257-266. PubMed
    2. 29265. Dessirier, J. M., Nguyen, N., Sieffermann, J. M., Carstens, E., and O'Mahony, M. Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects. Chem.Senses 1999;24(4):405-413. PubMed
    3. 29266. Stevens, D. A. and Lawless, H. T. Enhancement of responses to sequential presentation of oral chemical irritants. Physiol Behav. 1987;39(1):63-65. PubMed
    4. 29267. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
    5. 29263. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI

    Crofelemer

    Listed in the ADVERSE REACTIONS section of the FDA label for Crofelemer. Read the label on DailyMed ›

Reported for White Pepper but not commonly for Crofelemer: stomach upset, an allergic reaction, dizziness and headache.

Effects for Crofelemer come from the ADVERSE REACTIONS section of its FDA label; effects for White Pepper come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 233 voluntary FDA FAERS reports for Crofelemer that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

White Pepper in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of topical white pepper or white pepper oil when used in medicinal amounts during pregnancy.

Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of white pepper when used in medicinal amounts during breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Crofelemer Is Prescribed For, and What White Pepper Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Crofelemer is a prescription medicine with approved uses on its FDA label. White Pepper is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Crofelemer is prescribed for: Mytesi (crofelemer) is approved to provide symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy. It is not intended to treat diarrhea caused by an infection. Before starting Mytesi, a doctor will rule out infectious causes of diarrhea.

White Pepper has been studied for:

  • Diarrhea studied, not established White Pepper has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    White Pepper for diarrhea

    Preliminary clinical research in children ages 2 months to 2.5 years shows that covering the navel with cooked and ground white pepper is more effective for curing acute or persistent diarrhea, but not chronic diarrhea, when compared with oral montmorillonite (clay) powder. Cure was defined as no diarrhea within three days of initiating treatment.

    1 source cited
    1. 94016. Jin CQ, Jia YX, Dong HX, Zhou JW, Sun GF, Zhang YY, Zhao Q, Zheng BY. Stir-fried white pepper can treat diarrhea in infants and children efficiently: a randomized controlled trial. Am J Chin Med. 2013;41(4):765-72. doi: 10.1142/S0192415X13500511. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Crofelemer on your own; if you are taking White Pepper for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Crofelemer

This page covers White Pepper only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crofelemer page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Crofelemer interaction page

One more smart check

Taking White Pepper as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing White Pepper, each one broken down to its full ingredient list — and combination products often carry several ingredients besides White Pepper. Even though White Pepper itself has no known interaction with Crofelemer, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where White Pepper and Crofelemer Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement White Pepper
Top half

#724 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Crofelemer
Steady interest

#2,581 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every White Pepper reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The White Pepper and Crofelemer records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About White Pepper

What is White Pepper?

  • Digestive upset
  • Seasoning and appetite support
  • Cough and cold remedies (traditional)
  • Minor aches and pains (traditional)
  • Antimicrobial (traditional)

White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice. In normal food amounts it is generally safe for most people, but there is little solid human research supporting its use as a medicine. Talk with your pharmacist or doctor before using concentrated supplements, especially if you are pregnant, breastfeeding, or have a health condition.

Piper nigrum · Piperaceae · Dried, ripe seeds (with the outer fruit layer removed) · Ground powder, whole peppercorns, culinary spice, and occasionally capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether White Pepper is a good idea for someone in your situation. Here is what our White Pepper record says about it on its own.

White Pepper: dosing

There is no established medicinal dose for white pepper. As a spice, people simply use the amount that tastes good in cooking.If you are considering a white pepper or piperine supplement, follow the directions on the product label and do not exceed the recommended amount.

From our White Pepper monograph — the full record covers uses, side effects and every documented interaction.

Read the full White Pepper monograph & all interactions
Medication

About Crofelemer

What Is Crofelemer Used For?

Brand names: Fulyzaq, Mytesi

Mytesi (crofelemer) is approved to provide symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

It is not intended to treat diarrhea caused by an infection. Before starting Mytesi, a doctor will rule out infectious causes of diarrhea.

Most-Reported Side Effects for Crofelemer

From FAERS, the FDA’s public side-effect reporting system (233 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 26 reports
Anxiety 14 reports
Emotional distress 14 reports
Anhedonia 12 reports
Fatigue 11 reports
See full Crofelemer drug information
Keep checking

Other Drugs & White Pepper

Browse every other medication we’ve checked against White Pepper — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
976Moderate
3Minor
1,850No known interaction
976 Moderate 3 Minor 1,850 No interaction
Moderate

976 interactions

Showing 60 of 976 moderate interactions — see all 976 on the White Pepper page.

Minor

3 interactions

No interaction 1,850 drugs checked — show the list

We also checked White Pepper against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,850 medications checked with no known interaction — see the full White Pepper list.

See the full White Pepper interactions page
See every supplement checked against Crofelemer, ranked by severity
Evidence & sources

White Pepper References

The 28 references that drive our White Pepper monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  3. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  4. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  5. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  6. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  7. Stager, J., Wuthrich, B., and Johansson, S. G. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475-478. PubMed
  8. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
  9. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
  10. Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
  11. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
  12. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
  13. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI
  14. Dessirier, J. M., Nguyen, N., Sieffermann, J. M., Carstens, E., and O'Mahony, M. Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects. Chem.Senses 1999;24(4):405-413. PubMed
  15. Stevens, D. A. and Lawless, H. T. Enhancement of responses to sequential presentation of oral chemical irritants. Physiol Behav. 1987;39(1):63-65. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking White Pepper and Crofelemer Together: Common Questions

Is it safe to take White Pepper with Crofelemer?
We do not list a known interaction between White Pepper and Crofelemer. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do White Pepper and Crofelemer have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are White Pepper and Crofelemer used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for White Pepper in each. That is a conversation for your prescriber, especially if Crofelemer is being adjusted to a target.
How was the White Pepper and Crofelemer combination checked?
Interactions in our licensed database are recorded against drug classes. Crofelemer is filed under 1 classification, and White Pepper has documented interactions with 16 drug classes — none of Crofelemer's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does White Pepper interact with any other medications?
Yes. White Pepper has 979 documented drug interactions in our database — Crofelemer is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Crofelemer interact with any supplements?
Yes. Crofelemer has documented interactions with 17 supplements in our database — White Pepper is not one of them. The Crofelemer interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

White Pepper monograph Uses, safety profile, and every drug interaction in one place Crofelemer drug information The full plain-English guide to this medication Crofelemer supplement interactions Every supplement checked against Crofelemer, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 28 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.