Drug & supplement interaction

White Pepper + Daptomycin

Daptomycin brand names: Cubicin, Dapzura RT.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between White Pepper and Daptomycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

White Pepper and Daptomycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Daptomycin and White Pepper in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

White Pepper safety at a glance

White Pepper overall Generally safe Generally safe in the small amounts used to flavor food.

Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of topical white pepper or white pep... Read the full pregnancy detail

Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of white pepper when used in medicina... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Daptomycin and White Pepper? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Daptomycin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Daptomycin is filed under a single classification — antibiotic drugs. White Pepper has documented interactions with 16 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cyclosporine (neoral, sandimmune) (moderate) — and none of Daptomycin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

White Pepper Does Interact With Other Medications

White Pepper has 976 moderate, 3 minor known drug interactions in our database — Daptomycin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 976 Minor 3 No known interaction 1,851 (incl. Daptomycin)

Taking anything else?

Check Another of Your Medications Against White Pepper

Covers the 2,830 medications we’ve checked against White Pepper. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests White Pepper and Daptomycin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

An allergic reaction Worth acting on Additional detail
White Pepper
“Orally, white pepper can cause dyspepsia and other gastrointestinal discomfort. When given in a nasal spray, white pepper has been reported to cause cardiovascular, gastrointestinal, neurologic, and respiratory effects. Rarely, white pepper has been reported to cause allergic reaction.”

White Pepper · Natural Medicines adverse-effect record, reported in dyspepsia.
6 sources cited

29263. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI

29265. Dessirier, J. M., Nguyen, N., Sieffermann, J. M., Carstens, E., and O'Mahony, M. Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects. Chem.Senses 1999;24(4):405-413. PubMed

29266. Stevens, D. A. and Lawless, H. T. Enhancement of responses to sequential presentation of oral chemical irritants. Physiol Behav. 1987;39(1):63-65. PubMed

29267. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed

25599. Stager, J., Wuthrich, B., and Johansson, S. G. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475-478. PubMed

46241. Niinimaki, A., Hannuksela, M., and Makinen-Kiljunen, S. Skin prick tests and in vitro immunoassays with native spices and spice extracts. Ann.Allergy Asthma Immunol. 1995;75(3):280-286.
Daptomycin

Listed in the ADVERSE REACTIONS section of the FDA label for Daptomycin. Read the label on DailyMed ›
Sweating Additional detail
White Pepper
“When given in a nasal spray, piperine, a constituent of black pepper, induced sweating in 17 out of 127 study participants and cold hands and feet in 18 out of 127 participants.”

White Pepper · Natural Medicines adverse-effect record, reported in common cold.
1 source cited

29263. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI
Daptomycin

Listed in the ADVERSE REACTIONS section of the FDA label for Daptomycin. Read the label on DailyMed ›
Dizziness / Headache Additional detail
White Pepper
“When given in a nasal spray, piperine, a constituent of white pepper, induced headache, lightheadedness, dizziness, and feeling calm, alert, or "high" in up to 82 out of 127 study participants.”

White Pepper · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

29263. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI
Daptomycin

Listed in the ADVERSE REACTIONS section of the FDA label for Daptomycin. Read the label on DailyMed ›

Reported for White Pepper but not commonly for Daptomycin: stomach upset and nausea.

Effects for Daptomycin come from the ADVERSE REACTIONS section of its FDA label; effects for White Pepper come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 9,174 voluntary FDA FAERS reports for Daptomycin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

White Pepper in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of topical white pepper or white pepper oil when used in medicinal amounts during pregnancy.

Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of white pepper when used in medicinal amounts during breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Daptomycin

This page covers White Pepper only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Daptomycin page lists 27 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate), Bifidobacterium Bifidum (moderate) and Bifidobacterium Breve (moderate).

By severity: 26 moderate · 1 minor.

From our pharmacist’s overview on the Daptomycin page

“Every one of the 27 supplement interactions on file for daptomycin (Cubicin, Dapzura RT) tells the same story. It is a potent IV antibiotic used for serious infections such as MRSA, and like any antibiotic it can kill the live organisms in probiotic supplements and fermented milk products, blunting their benefit rather than the drug's.”

Reviewed by 2 · Jul 18, 2026

Open the Daptomycin interaction page

One more smart check

Taking White Pepper as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing White Pepper, each one broken down to its full ingredient list — and combination products often carry several ingredients besides White Pepper. Even though White Pepper itself has no known interaction with Daptomycin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where White Pepper and Daptomycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement White Pepper

Steady interest

#1,224 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Daptomycin

Top 5%

#138 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every White Pepper reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The White Pepper and Daptomycin records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About White Pepper

What is White Pepper?

Digestive upset
Seasoning and appetite support
Cough and cold remedies (traditional)
Minor aches and pains (traditional)
Antimicrobial (traditional)

White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice. In normal food amounts it is generally safe for most people, but there is little solid human research supporting its use as a medicine. Talk with your pharmacist or doctor before using concentrated supplements, especially if you are pregnant, breastfeeding, or have a health condition.

Piper nigrum · Piperaceae · Dried, ripe seeds (with the outer fruit layer removed) · Ground powder, whole peppercorns, culinary spice, and occasionally capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether White Pepper is a good idea for someone in your situation. Here is what our White Pepper record says about it on its own.

White Pepper: dosing

There is no established medicinal dose for white pepper. As a spice, people simply use the amount that tastes good in cooking.If you are considering a white pepper or piperine supplement, follow the directions on the product label and do not exceed the recommended amount.

From our White Pepper monograph — the full record covers uses, side effects and every documented interaction.

Read the full White Pepper monograph & all interactions

Medication

About Daptomycin Injection

What Is Daptomycin Injection Used For?

Brand names: Cubicin, Dapzura RT

Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI) caused by specific gram-positive bacteria — including MRSA (methicillin-resistant Staphylococcus aureus) — in adults and children ages 1 to 17. It is also used to treat Staphylococcus aureus bloodstream infections (bacteremia) in adults and children ages 1 to 17, including adult patients with right-sided infective endocarditis (a serious infection of the heart's inner lining).

Important limits: daptomycin injection is not approved for pneumonia or for left-sided infective endocarditis due to S. aureus. It is also not recommended for infants under 1 year of age due to potential risks to the muscular and nervous systems seen in animal studies.

Most-Reported Side Effects for Daptomycin

From FAERS, the FDA’s public side-effect reporting system (9,174 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Acute kidney injury 599 reports

Fever 478 reports

Eosinophilic pneumonia 465 reports

Rhabdomyolysis 370 reports

Eosinophilia 364 reports

See full Daptomycin Injection drug information

Keep checking

Other Drugs & White Pepper

Browse every other medication we’ve checked against White Pepper — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

976Moderate

3Minor

1,850No known interaction

976 Moderate 3 Minor 1,850 No interaction

Moderate

976 interactions

Showing 60 of 976 moderate interactions — see all 976 on the White Pepper page.

Minor

3 interactions

No interaction 1,850 drugs checked — show the list

We also checked White Pepper against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,850 medications checked with no known interaction — see the full White Pepper list.

See the full White Pepper interactions page

See every supplement checked against Daptomycin, ranked by severity

Evidence & sources

White Pepper References

The 28 references that drive our White Pepper monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
Stager, J., Wuthrich, B., and Johansson, S. G. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475-478. PubMed
Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Franzon, M., Jarvik, M. E., and Steinberg, C. Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. Addiction 1995;90(12):1671-1682. DOI
Dessirier, J. M., Nguyen, N., Sieffermann, J. M., Carstens, E., and O'Mahony, M. Oral irritant properties of piperine and nicotine: psychophysical evidence for asymmetrical desensitization effects. Chem.Senses 1999;24(4):405-413. PubMed
Stevens, D. A. and Lawless, H. T. Enhancement of responses to sequential presentation of oral chemical irritants. Physiol Behav. 1987;39(1):63-65. PubMed
Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
Rentmeister-Bryant, H. and Green, B. G. Perceived irritation during ingestion of capsaicin or piperine: comparison of trigeminal and non-trigeminal areas. Chem.Senses 1997;22(3):257-266. PubMed
Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. PubMed
Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. PubMed
Aher, S., Biradar, S., Gopu, C. L., and Paradkar, A. Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm.Pharmacol. 2009;61(9):1179-1186. PubMed
Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224.
Niinimaki, A., Hannuksela, M., and Makinen-Kiljunen, S. Skin prick tests and in vitro immunoassays with native spices and spice extracts. Ann.Allergy Asthma Immunol. 1995;75(3):280-286.
Meding, B. Skin symptoms among workers in a spice factory. Contact Dermatitis 1993;29(4):202-205. PubMed
van den Akker, T. W., Roesyanto-Mahadi, I. D., van Toorenenbergen, A. W., and van Joost, T. Contact allergy to spices. Contact Dermatitis 1990;22(5):267-272. PubMed
Niinimaki, A., Bjorksten, F., Puukka, M., Tolonen, K., and Hannuksela, M. Spice allergy: results of skin prick tests and RAST with spice extracts. Allergy 1989;44(1):60-65. PubMed
Jin CQ, Jia YX, Dong HX, Zhou JW, Sun GF, Zhang YY, Zhao Q, Zheng BY. Stir-fried white pepper can treat diarrhea in infants and children efficiently: a randomized controlled trial. Am J Chin Med. 2013;41(4):765-72. doi: 10.1142/S0192415X13500511. PubMed
Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci. 2019;218:314-323. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Daptomycin Is Linked to Lower Levels of 7 Nutrients

Natural Medicines records Daptomycin as a medicine that can lower these. This is not an interaction with White Pepper — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Daptomycin nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking White Pepper and Daptomycin Together: Common Questions

Is it safe to take White Pepper with Daptomycin?

We do not list a known interaction between White Pepper and Daptomycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do White Pepper and Daptomycin have any of the same side effects?

Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the White Pepper and Daptomycin combination checked?

Interactions in our licensed database are recorded against drug classes. Daptomycin is filed under 1 classification, and White Pepper has documented interactions with 16 drug classes — none of Daptomycin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does White Pepper interact with any other medications?

Yes. White Pepper has 979 documented drug interactions in our database — Daptomycin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Daptomycin interact with any supplements?

Yes. Daptomycin has documented interactions with 27 supplements in our database — White Pepper is not one of them. The Daptomycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

White Pepper monograph Uses, safety profile, and every drug interaction in one place Daptomycin Injection drug information The full plain-English guide to this medication Daptomycin supplement interactions Every supplement checked against Daptomycin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 28 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Daptomycin and White Pepper?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.