Drug & supplement interaction

Wild Carrot + Irbesartan, Hydrochlorothiazide

Irbesartan, Hydrochlorothiazide brand name: CoAprovel.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Irbesartan, Hydrochlorothiazide falls into 2 drug categories that Wild Carrot can interact with; the most serious is rated moderate. Theoretically, excessive doses of wild carrot seed oil might interfere with antihypertensive therapy due to cardiotonic effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Wild Carrot and Irbesartan, Hydrochlorothiazide

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Wild Carrot interacts with whole categories of medication. Irbesartan, Hydrochlorothiazide falls into 2 of those categories, so it can interact with Wild Carrot in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Irbesartan, Hydrochlorothiazide

Irbesartan, Hydrochlorothiazide falls under ANTIHYPERTENSIVE DRUGS — the group Wild Carrot interacts with.

Theoretically, excessive doses of wild carrot seed oil might interfere with antihypertensive therapy due to cardiotonic effects.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your CoAprovel combines two blood pressure lowerers: irbesartan, which relaxes blood vessels, and hydrochlorothiazide, a water pill that helps your body shed extra fluid and salt. Neither one is a prodrug, so this isn't about how your body activates the medicine.

The concern here is purely theoretical. In lab settings, the essential oil from wild carrot seeds has shown effects on the heart and blood vessels that might work against your blood pressure treatment, possibly leaving your numbers higher than they should be. This is only based on pharmacology, not real human studies, and ordinary culinary amounts of carrot won't matter. Concentrated seed-oil supplements are the worry. If you'd like to try wild carrot, check with your pharmacist or doctor first and keep monitoring your blood pressure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Moderate

PHOTOSENSITIZING DRUGS

2 of 2

Irbesartan, Hydrochlorothiazide also falls under PHOTOSENSITIZING DRUGS.

Theoretically, concomitant use might result in increased photosensitivity. Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the deal with combining wild carrot and CoAprovel (irbesartan with hydrochlorothiazide). Wild carrot contains plant oils that may make your skin more sensitive to sunlight. The hydrochlorothiazide piece of your combo pill is already a known sun-sensitizer, so the worry is that stacking the two could add up. In real life that might mean you burn faster or break out in a rash after time outdoors, even on a day when you'd normally be fine.

I'll be straight with you though: this is a theoretical concern based on how these things work, not something proven in studies. It's easy to play it safe by using sunscreen, a hat, and shade. If you'd like to use wild carrot, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Wild Carrot Also Interacts With Other Medications

Wild Carrot has 474 moderate known drug interactions in our database — the Irbesartan, Hydrochlorothiazide one above is among them. If you take anything else, check it against the full list below.

Moderate 474 No known interaction 2,356 (incl. Irbesartan, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Wild Carrot

Covers the 2,830 medications we’ve checked against Wild Carrot. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Irbesartan, Hydrochlorothiazide

This page covers Wild Carrot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Irbesartan, Hydrochlorothiazide page lists 273 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 226 moderate · 37 minor.

Open the Irbesartan, Hydrochlorothiazide interaction page

One more smart check

Taking Wild Carrot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Wild Carrot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Carrot. Your product may carry other ingredients that interact with Irbesartan, Hydrochlorothiazide too, on top of Wild Carrot — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Carrot and Irbesartan, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Carrot
Steady interest

#1,157 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Irbesartan, Hydrochlorothiazide
Top 10%

#221 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Wild Carrot

What is Wild Carrot?

Wild Carrot
  • Urinary and bladder complaints
  • Digestive upset and gas
  • Menstrual support
  • Supporting milk production
  • Mild diuretic (water pill) effect

Wild carrot is a traditional herb (the wild ancestor of the garden carrot) used mostly for urinary, digestive, and menstrual complaints. High-quality human studies are lacking, so its benefits are unproven, and it should be avoided in pregnancy because of traditional use to affect the uterus. Talk with your pharmacist or doctor before using it.

Read the full Wild Carrot monograph & all interactions
Keep checking

Other Drugs & Wild Carrot

Browse every other medication we’ve checked against Wild Carrot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
474Moderate
0Minor
2,355No known interaction
474 Moderate 2,355 No interaction
Moderate

474 interactions

Showing 60 of 474 moderate interactions — see all 474 on the Wild Carrot page.

No interaction 2,355 drugs checked — show the list

We also checked Wild Carrot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,355 medications checked with no known interaction — see the full Wild Carrot list.

See the full Wild Carrot interactions page
See every supplement checked against Irbesartan, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Wild Carrot monograph › Uses, safety, and every drug interaction in one place Irbesartan, Hydrochlorothiazide supplement interactions › Every supplement checked against Irbesartan, Hydrochlorothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Wild Carrot and Irbesartan, Hydrochlorothiazide Together: Common Questions

Can you take Wild Carrot with Irbesartan, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Wild Carrot and Irbesartan, Hydrochlorothiazide?
Irbesartan, Hydrochlorothiazide belongs to more than one drug category, and Wild Carrot interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Wild Carrot and Irbesartan, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.