Drug & supplement interaction

Wild Cherry + Elexacaftor, Tezacaftor, Ivacaftor

Elexacaftor, Tezacaftor, Ivacaftor brand name: Trikafta.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Wild Cherry has a moderate interaction with Elexacaftor, Tezacaftor, Ivacaftor. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Wild Cherry and Elexacaftor, Tezacaftor, Ivacaftor

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Elexacaftor, Tezacaftor, Ivacaftor

Elexacaftor, Tezacaftor, Ivacaftor falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Wild Cherry interacts with.

In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes. Theoretically, wild cherry might increase levels of drugs metabolized by CYP3A4. However, so far, this interaction has not been reported in humans.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the quick picture with Trikafta. All three pieces of this medicine (elexacaftor, tezacaftor, and ivacaftor) are cleared by a liver enzyme called CYP3A4. Lab studies hint that wild cherry may slow that enzyme down. If that happened in real life, your body could break Trikafta down a little less, letting levels creep up. That might mean more of the side effects this combo is known for, like headache, belly pain, diarrhea, a rash, or changes on liver blood tests.

I want to be honest, though: this is only a test-tube finding, and it has never been reported in actual patients. Normal cough-syrup or lozenge amounts of wild cherry are unlikely to cause trouble. Still, since Trikafta matters so much for your lungs, run any wild cherry product by your pharmacist or CF team first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Wild Cherry Also Interacts With Other Medications

Wild Cherry has 642 moderate known drug interactions in our database — the Elexacaftor, Tezacaftor, Ivacaftor one above is one of them. If you take anything else, check it against the full list below.

Moderate 642 No known interaction 2,188 (incl. Elexacaftor, Tezacaftor, Ivacaftor)
Taking anything else?

Check Another of Your Medications Against Wild Cherry

Covers the 2,830 medications we’ve checked against Wild Cherry. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Elexacaftor, Tezacaftor, Ivacaftor

This page covers Wild Cherry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Elexacaftor, Tezacaftor, Ivacaftor page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Elexacaftor, Tezacaftor, Ivacaftor page

“Grapefruit is the first thing I would flag for anyone taking Trikafta (elexacaftor, tezacaftor, ivacaftor). All three components of this cystic fibrosis medicine are cleared by the CYP3A4 enzyme, and grapefruit blocks that enzyme, raising drug levels and the odds of side effects.”

Reviewed by 2 · Jul 18, 2026

Open the Elexacaftor, Tezacaftor, Ivacaftor interaction page

One more smart check

Taking Wild Cherry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 439 real supplement products containing Wild Cherry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Cherry. Your product may carry other ingredients that interact with Elexacaftor, Tezacaftor, Ivacaftor too, on top of Wild Cherry — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Cherry and Elexacaftor, Tezacaftor, Ivacaftor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Cherry
Top 25%

#336 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Elexacaftor, Tezacaftor, Ivacaftor
Top 10%

#270 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Wild Cherry

What is Wild Cherry?

Wild Cherry
  • Cough
  • Bronchitis and respiratory irritation
  • Sore throat
  • Digestive upset and diarrhea
  • Flavoring agent

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence proving it works. The bark, leaves, and seeds naturally contain cyanide-producing compounds, so it should be used only in properly prepared products and avoided in large amounts. Talk with a pharmacist or doctor before using it, especially during pregnancy or for children.

Read the full Wild Cherry monograph & all interactions
Medication

About Elexacaftor, Tezacaftor, and Ivacaftor

What Is Elexacaftor, Tezacaftor, and Ivacaftor Used For?

Brand name: Trikafta

Trikafta (elexacaftor, tezacaftor, and ivacaftor) is used to treat cystic fibrosis (CF) in adults and children aged 2 years and older who have a clinical diagnosis of CF and carry at least one CFTR gene variant that is expected to respond to the medication — either based on clinical trial data or laboratory testing.

If a patient's genetic variant is not already known, an FDA-cleared CF genetic test should be used to confirm eligibility before starting treatment.

See full Elexacaftor, Tezacaftor, and Ivacaftor drug information
Keep checking

Other Drugs & Wild Cherry

Browse every other medication we’ve checked against Wild Cherry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
642Moderate
0Minor
2,187No known interaction
642 Moderate 2,187 No interaction
Moderate

642 interactions

Showing 60 of 642 moderate interactions — see all 642 on the Wild Cherry page.

No interaction 2,187 drugs checked — show the list

We also checked Wild Cherry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,187 medications checked with no known interaction — see the full Wild Cherry list.

See the full Wild Cherry interactions page
See every supplement checked against Elexacaftor, Tezacaftor, Ivacaftor, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Wild Cherry monograph › Uses, safety, and every drug interaction in one place Elexacaftor, Tezacaftor, Ivacaftor supplement interactions › Every supplement checked against Elexacaftor, Tezacaftor, Ivacaftor, ranked by severity Elexacaftor, Tezacaftor, and Ivacaftor drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Wild Cherry and Elexacaftor, Tezacaftor, Ivacaftor Together: Common Questions

Can you take Wild Cherry with Elexacaftor, Tezacaftor, Ivacaftor?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Wild Cherry and Elexacaftor, Tezacaftor, Ivacaftor interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Elexacaftor, Tezacaftor, Ivacaftor and Wild Cherry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.