Medication interaction hub

What Supplements Interact with Elexacaftor, Tezacaftor, Ivacaftor?

Elexacaftor, Tezacaftor, Ivacaftor brand name: Trikafta. Every interaction below applies to the brands too.

138 Interactions 3 Major 94 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Elexacaftor, Tezacaftor, Ivacaftor? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Elexacaftor, Tezacaftor, Ivacaftor against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the first thing I would flag for anyone taking Trikafta (elexacaftor, tezacaftor, ivacaftor). All three components of this cystic fibrosis medicine are cleared by the CYP3A4 enzyme, and grapefruit blocks that enzyme, raising drug levels and the odds of side effects. It is one of just three major-rated entries among the 138 supplements and herbs on this page, and the list as a whole warrants real vigilance, not a quick skim.

Most of the rest tells the same enzyme story. Of the 138, 121 can nudge CYP3A4 in either direction, sending Trikafta levels up (more side effects) or down (less benefit for your lungs). St. John's wort, another major, pushes them down, while activated charcoal, the third, can soak up the dose in the gut before it reaches the bloodstream. The 94 moderate and 41 minor entries mostly repeat these themes with weaker evidence, which is why the three majors belong at the top of your reading.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 94 Minor 41 No known interaction 1,314

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Elexacaftor, Tezacaftor, Ivacaftor: Top Interactions at a Glance

The most significant Elexacaftor, Tezacaftor, Ivacaftor supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 138 interacting ingredients — plus 1,314 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Elexacaftor, Tezacaftor, Ivacaftor + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Elexacaftor, Tezacaftor, Ivacaftori

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Elexacaftor, Tezacaftor, Ivacaftori

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Elexacaftor, Tezacaftor, Ivacaftori

St.

Read the full interaction
The complete list

Every Supplement Checked Against Elexacaftor, Tezacaftor, Ivacaftor

All 1,452 ingredients in our database, ranked by severity — 138 with a Elexacaftor, Tezacaftor, Ivacaftor interaction on file and 1,314 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Elexacaftor, Tezacaftor, Ivacaftor?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Karaya Gum with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Marshmallow with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Melatonin with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Passion Flower with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Puravive with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Rhodiola with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Valerian with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Vitamin D with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Xanthan Gum with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Yerba Mate with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Yohimbe with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Eleuthero with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Green Tea with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Gymnema with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Humann Superbeets Heart Chews with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Jequirity with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Kava with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Milk Thistle with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Elexacaftor, Tezacaftor, Ivacaftor answer

Can you take Mommy's Bliss Gripe Water with Elexacaftor, Tezacaftor, Ivacaftor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Elexacaftor, Tezacaftor, Ivacaftor answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Elexacaftor, Tezacaftor, Ivacaftor is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Elexacaftor, Tezacaftor, Ivacaftor, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Elexacaftor, Tezacaftor, Ivacaftor sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Elexacaftor, Tezacaftor, Ivacaftor through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Elexacaftor, Tezacaftor, Ivacaftor through this category.

About Elexacaftor, Tezacaftor, Ivacaftor

Elexacaftor, tezacaftor, and ivacaftor is a three-medicine combination used to treat cystic fibrosis in patients aged 2 years and older who have certain genetic variants in the CFTR gene.

Generic name: Elexacaftor, Tezacaftor, Ivacaftor  ·  Brand name: Trikafta.

See the full Elexacaftor, Tezacaftor, and Ivacaftor drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Elexacaftor, Tezacaftor, Ivacaftor

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Elexacaftor, Tezacaftor, Ivacaftor.

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Pharmacist Counseling Corner

Elexacaftor, Tezacaftor, Ivacaftor & Supplements: Common Questions

What supplements interact with Elexacaftor, Tezacaftor, Ivacaftor?
Our database currently documents 138 ingredients with a known Elexacaftor, Tezacaftor, Ivacaftor interaction (3 major, 94 moderate, 41 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 138. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Elexacaftor, Tezacaftor, Ivacaftor supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Elexacaftor, Tezacaftor, Ivacaftor?
Plenty of supplements coexist fine with Elexacaftor, Tezacaftor, Ivacaftor; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Trikafta have the same supplement interactions as Elexacaftor, Tezacaftor, Ivacaftor?
Yes — Trikafta all contain Elexacaftor, Tezacaftor, Ivacaftor, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Elexacaftor, Tezacaftor, Ivacaftor and my other medications?
This page covers Elexacaftor, Tezacaftor, Ivacaftor against supplements and herbal ingredients. Checking Elexacaftor, Tezacaftor, Ivacaftor against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Elexacaftor, Tezacaftor, and Ivacaftor drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.