Drug & supplement interaction

Wild Yam + Abaloparatide

Abaloparatide brand name: Tymlos.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wild Yam and Abaloparatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wild Yam and Abaloparatide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Abaloparatide and Wild Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wild Yam safety at a glance

Wild Yam overall Use caution Likely fine for short-term use in healthy adults, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Abaloparatide and Wild Yam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Wild Yam Does Interact With Other Medications

Wild Yam has 41 moderate known drug interactions in our database — Abaloparatide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 No known interaction 2,789 (incl. Abaloparatide)
Taking anything else?

Check Another of Your Medications Against Wild Yam

Covers the 2,830 medications we’ve checked against Wild Yam. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wild Yam and Abaloparatide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 17.5% of FDA reports for Abaloparatide Additional detail

    Wild Yam

    “Orally, wild yam can cause headache and fever, especially at higher doses.”

    Wild Yam · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Abaloparatide

    Listed in the ADVERSE REACTIONS section of the FDA label for Abaloparatide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Vomiting Additional detail

    Wild Yam

    “Orally, wild yam can cause upset stomach and vomiting, especially at higher doses (12,86450).”

    Wild Yam · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Abaloparatide

    Listed in the ADVERSE REACTIONS section of the FDA label for Abaloparatide. Read the label on DailyMed ›

Reported for Wild Yam but not commonly for Abaloparatide: stomach upset, a severe allergic reaction, loss of vision and blood clots.

Effects for Abaloparatide come from the ADVERSE REACTIONS section of its FDA label; effects for Wild Yam come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 29,258 voluntary FDA FAERS reports for Abaloparatide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Abaloparatide Is Prescribed For, and What Wild Yam Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Abaloparatide is a prescription medicine with approved uses on its FDA label. Wild Yam is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Abaloparatide is prescribed for: Tymlos (abaloparatide) subcutaneous injection is used to treat osteoporosis in postmenopausal women who are at high risk for fracture — meaning they have a history of osteoporotic fracture or multiple risk factors. In these women, Tymlos reduces the risk of both spinal (vertebral) and non-spinal (nonvertebral) fractures. It is also used when other osteoporosis treatments have not worked or were not tolerated. Tymlos is also indicated to increase bone density in men with osteoporosis who are at high risk for fracture, or who have failed or cannot tolerate other osteoporosis therapies.

Wild Yam has been studied for:

  • Osteoporosis studied, not established Wild Yam has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Wild Yam for osteoporosis

    Although there is interest in using oral wild yam for osteoporosis, there is insufficient reliable information about the clinical effects of wild yam for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Abaloparatide on your own; if you are taking Wild Yam for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Wild Yam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,014 real supplement products containing Wild Yam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Yam. Even though Wild Yam itself has no known interaction with Abaloparatide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Yam and Abaloparatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Yam
Top 25%

#227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Abaloparatide
Steady interest

#1,549 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wild Yam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wild Yam and Abaloparatide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wild Yam

What is Wild Yam?

  • Menopausal symptoms
  • Menstrual cramps
  • Hormone balance (popular belief)
  • Digestive cramps
  • Joint and muscle discomfort

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular claims, your body cannot convert its compounds into hormones like progesterone, so creams marketed that way usually don't work as advertised. Talk with a pharmacist or doctor before using it.

Dioscorea villosa · Dioscoreaceae · Root and rhizome (underground stem) · Capsules, tablets, dried root, tinctures, topical creams, tea

An interaction check asks whether these two react with each other — it does not ask whether Wild Yam is a good idea for someone in your situation. Here is what our Wild Yam record says about it on its own.

Wild Yam: dosing

There is no well-established standard dose for wild yam. The amount can vary widely between products and forms (capsules, tinctures, teas, or creams).The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Wild Yam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wild Yam monograph & all interactions
Medication

About Abaloparatide Injection

What Is Abaloparatide Injection Used For?

Brand name: Tymlos

Tymlos (abaloparatide) subcutaneous injection is used to treat osteoporosis in postmenopausal women who are at high risk for fracture — meaning they have a history of osteoporotic fracture or multiple risk factors. In these women, Tymlos reduces the risk of both spinal (vertebral) and non-spinal (nonvertebral) fractures. It is also used when other osteoporosis treatments have not worked or were not tolerated.

Tymlos is also indicated to increase bone density in men with osteoporosis who are at high risk for fracture, or who have failed or cannot tolerate other osteoporosis therapies.

Most-Reported Side Effects for Abaloparatide

From FAERS, the FDA’s public side-effect reporting system (29,258 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 5,123 reports
Nausea 3,913 reports
Dizziness 3,860 reports
Fatigue 3,419 reports
Heart rate increased 2,593 reports
See full Abaloparatide Injection drug information
Keep checking

Other Drugs & Wild Yam

Browse every other medication we’ve checked against Wild Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
0Minor
2,788No known interaction
41 Moderate 2,788 No interaction
Moderate

41 interactions

No interaction 2,788 drugs checked — show the list

We also checked Wild Yam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,788 medications checked with no known interaction — see the full Wild Yam list.

See the full Wild Yam interactions page
See every supplement checked against Abaloparatide, ranked by severity
Evidence & sources

Wild Yam References

The 7 references that drive our Wild Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wild Yam and Abaloparatide Together: Common Questions

Is it safe to take Wild Yam with Abaloparatide?
We do not list a known interaction between Wild Yam and Abaloparatide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wild Yam and Abaloparatide have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Wild Yam and Abaloparatide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Wild Yam in each. That is a conversation for your prescriber, especially if Abaloparatide is being adjusted to a target.
Does Wild Yam interact with any other medications?
Yes. Wild Yam has 41 documented drug interactions in our database — Abaloparatide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wild Yam monograph Uses, safety profile, and every drug interaction in one place Abaloparatide Injection drug information The full plain-English guide to this medication Abaloparatide supplement interactions Every supplement checked against Abaloparatide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Abaloparatide and Wild Yam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.