Drug & supplement interaction

Ylang Ylang Oil + Amitriptyline

Amitriptyline brand name: Elavil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ylang Ylang Oil and Amitriptyline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ylang Ylang Oil and Amitriptyline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amitriptyline and Ylang Ylang Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ylang Ylang Oil at all — not against Amitriptyline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ylang Ylang Oil safety at a glance

Ylang Ylang Oil overall Use caution Generally safe for aromatherapy or diluted topical use, but it can cause skin irritation and should not be taken by mouth.
Pregnancy Likely Safe When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable inf... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable inf... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amitriptyline and Ylang Ylang Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ylang Ylang Oil and Amitriptyline May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Ylang Ylang Oil

    “Topically, ylang ylang oil in combination with other herbs has caused contact dermatitis in various case reports.”

    Ylang Ylang Oil · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 98615. Posadzki P, Alotaibi A, Ernst E. Adverse effects of aromatherapy: a systematic review of case reports and case series. Int J Risk Saf Med. 2012;24(3):147-61. PubMed

    Amitriptyline

    Listed in the ADVERSE REACTIONS section of the FDA label for Amitriptyline. Read the label on DailyMed ›

Reported for Ylang Ylang Oil but not commonly for Amitriptyline: itching.

Effects for Amitriptyline come from the ADVERSE REACTIONS section of its FDA label; effects for Ylang Ylang Oil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 17,459 voluntary FDA FAERS reports for Amitriptyline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ylang Ylang Oil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in food. Ylang ylang oil has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of using ylang ylang oil in medicinal amounts. Additionally, there is insufficient reliable information available regarding use of ylang ylang oil as aromatherapy during labor. Ylang ylang oil aromatherapy has been used with apparent safety during active labor in a small clinical study. However, a high-quality assessment of safety has not been conducted.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Ylang Ylang Oil or Amitriptyline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ylang Ylang Oil or Amitriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amitriptyline

This page covers Ylang Ylang Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 17 major · 228 moderate · 51 minor.

From our pharmacist’s overview on the Amitriptyline page

“Amitriptyline (Elavil), an older antidepressant now often prescribed for nerve pain, migraines, and sleep, is one of the drugs I genuinely want patients to be careful with, and 17 of the 296 supplement and herbal ingredients on this list carry a major rating. Most of the serious ones deepen the drowsiness amitriptyline already causes,…”

Reviewed by 2 · Jul 18, 2026

Open the Amitriptyline interaction page

How much people look this up

Where Ylang Ylang Oil and Amitriptyline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ylang Ylang Oil
Steady interest

#1,439 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amitriptyline
Top 5%

#36 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ylang Ylang Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ylang Ylang Oil and Amitriptyline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ylang Ylang Oil

What is Ylang Ylang Oil?

  • Stress and anxiety relief
  • Aromatherapy and relaxation
  • Promoting restful sleep
  • Skin and hair care
  • Mood and well-being

Ylang ylang oil is a fragrant essential oil made from the flowers of the Cananga odorata tree, used mostly in aromatherapy and skin care for relaxation. Some small studies hint at mild calming effects, but the evidence is limited, and it should never be swallowed and must always be diluted before being applied to skin.

Cananga odorata · Annonaceae · Essential oil distilled from the flowers · Essential oil, diluted massage oil, aromatherapy blends, room diffusers, perfumes and cosmetics

An interaction check asks whether these two react with each other — it does not ask whether Ylang Ylang Oil is a good idea for someone in your situation. Here is what our Ylang Ylang Oil record says about it on its own.

Ylang Ylang Oil: dosing

There is no established standard dose for ylang ylang oil, and it is not meant to be taken internally. For aromatherapy, a few drops are typically added to a diffuser or inhaled briefly. For topical use, the oil should always be diluted to a low concentration in a carrier oil.Because products vary widely in strength, follow the directions on the label and start with the smallest amount.

From our Ylang Ylang Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ylang Ylang Oil monograph & all interactions
Medication

About Amitriptyline

What Is Amitriptyline Used For?

Brand name: Elavil

Amitriptyline HCL and Amitriptyline Hydrochloride tablets are used to relieve symptoms of depression. Depression that originates from within the body (called endogenous depression) tends to respond better than other types of depression.

Most-Reported Side Effects for Amitriptyline

From FAERS, the FDA’s public side-effect reporting system (17,459 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,535 reports
Headache 1,476 reports
Fatigue 1,448 reports
Dyspnea 1,442 reports
Dizziness 1,227 reports
See full Amitriptyline drug information
Keep checking

Other Drugs & Ylang Ylang Oil

Browse every other medication we’ve checked against Ylang Ylang Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ylang Ylang Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ylang Ylang Oil list.

See the full Ylang Ylang Oil interactions page
See every supplement checked against Amitriptyline, ranked by severity
Evidence & sources

Ylang Ylang Oil References

The 4 references that drive our Ylang Ylang Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
  3. Posadzki P, Alotaibi A, Ernst E. Adverse effects of aromatherapy: a systematic review of case reports and case series. Int J Risk Saf Med. 2012;24(3):147-61. PubMed
  4. Sirkeci I, Cagan O, Koc S. The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women: A randomized controlled trial. Complement Ther Clin Pract. 2023; 52:101748. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ylang Ylang Oil and Amitriptyline Together: Common Questions

Is it safe to take Ylang Ylang Oil with Amitriptyline?
We do not list a known interaction between Ylang Ylang Oil and Amitriptyline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ylang Ylang Oil and Amitriptyline have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Amitriptyline interact with any supplements?
Yes. Amitriptyline has documented interactions with 296 supplements in our database — Ylang Ylang Oil is not one of them. The Amitriptyline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ylang Ylang Oil monograph Uses, safety profile, and every drug interaction in one place Amitriptyline drug information The full plain-English guide to this medication Amitriptyline supplement interactions Every supplement checked against Amitriptyline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amitriptyline and Ylang Ylang Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.