Zizyphus - Aptivus (tipranavir) Interaction
Herbal: Zizyphus
Also Known As: Ziziphus jujuba, Anèbe, Annab, Azufaifo, Badar, Ber, Black Date, Black Jujube, Chinese Date, Chinese Jujube, Da Zao, Date Seed, Datte Chinoise, Datte Noire, Fructus Jujubae, Fructus Ju Jubae, Hei Zao, Hong Zao, Jujube, Jujube Chinois, Jujube Plum, Jujube Noir, Jujube Rouge
Drug: tipranavir
Brand names:
Aptivus
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
tipranavir is classified as belonging to the following category: Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Animal research shows that zizyphus induces CYP1A2 enzymes. However, this effect has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Jing XY, Peng YR, Wang XM, Duan JA. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015 Aug;13(8):588-94.
Zizyphus Overview
Zizyphus is a genus of trees and shrubs belonging to the buckthorn family (Rhamnaceae). There are several species of Zizyphus, including Zizyphus jujuba, Zizyphus lotus, and Zizyphus mauritiana. These are all traditionally associated with common names (such as Zizyphus jujuba being known as the Chinese date or red date).
In traditional medicine, the leaves, bark, and fruit of Zizyphus species are used to treat a variety of conditions, including insomnia, anxiety, and digestive problems. Most commonly, the fruit, which is edible and resembles a date, is used. It is rich in fiber, vitamin C, B vitamins, and some fatty acids.
Zizyphus - More Interactions
Zizyphus interacts with 465 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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