Herb & supplement monograph

Alpha-gpc Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Alpha-gpc interacts with medications. The heart of this page is the interaction list — every drug Alpha-gpc is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Alpha-gpc is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

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Alpha-gpc Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Alpha-gpc drug interaction appears low for most people. None of Alpha-gpc's known interactions are rated major or even moderate; every one on record is minor.

Interactions deserving the most attention

The only interaction worth singling out involves scopolamine, a medication used for motion sickness. A small human study found that alpha-GPC partially counteracted the attention and memory dulling caused by injected scopolamine, which suggests the two can work against each other. Whether alpha-GPC would also weaken the motion sickness benefit of the scopolamine patch is not clear, so people relying on that patch may want to keep this in mind. Beyond scopolamine, nothing in the profile rises to the level of a real safety concern.

What the rest of the list means

Although more than a dozen medications appear on Alpha-gpc's interaction list, all are graded minor, and the documented evidence is limited. Much of the concern is theoretical, and even the best-studied example showed only a partial, modest effect in a small study. A long list here reflects caution, not proven harm.

Check your medications against Alpha-gpc

Based on HelloPharmacist’s Alpha-gpc interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Alpha-gpc

16 medications have a known interaction with Alpha-gpc, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Alpha-gpc using our pharmacist-reviewed interaction data.

AI summaries are generated from our Alpha-gpc interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist