Alpha-gpc + Colesevelam
Colesevelam brand names: WelChol, Lodalis.
We found no known interaction between Alpha-gpc and Colesevelam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Colesevelam states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Alpha-gpc and Colesevelam
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Colesevelam and Alpha-gpc in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Alpha-gpc safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Colesevelam
Interactions in our licensed database are recorded against drug classes, not just single drug names. Colesevelam is filed under a single classification — oral drugs. Alpha-gpc has documented interactions with 1 drug class — the most serious being scopolamine (transderm scop) (minor) — and none of Colesevelam’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Alpha-gpc Does Interact With Other Medications
Alpha-gpc has 16 minor known drug interactions in our database — Colesevelam isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Alpha-gpc
We haven’t checked that one against Alpha-gpc yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Alpha-gpc. Pick one to open its full report.
Some Colesevelam Products Have a Food Rule — Alpha-gpc Should Not Break It
At least one FDA label for a product containing Colesevelam says to take it with food. If you take Alpha-gpc on an empty stomach out of habit, keep them separate — and take Colesevelam with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Colesevelam products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Colesevelam hydrochloride should be taken as follows ( 2.2 , 2.4 ): Tablets Take 6 tablets once daily or 3 tablets twice daily with a meal and liquid.
From the Dosage and Administration section of the FDA label we read for Colesevelam — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Alpha-gpc or Colesevelam
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Alpha-gpc or Colesevelam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Colesevelam
This page covers Alpha-gpc only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Colesevelam page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Colesevelam page
“Colesevelam (WelChol, Lodalis) lowers cholesterol by binding bile acids in your gut, and every one of the 17 supplements on this list can interfere with how oral medicines are absorbed in that same territory. I would treat this list with genuine care, and the place to start is activated charcoal, the only major-rated entry.”
Reviewed by 2 · Jul 18, 2026
Taking Alpha-gpc as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,138 real supplement products containing Alpha-gpc, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alpha-gpc. Even though Alpha-gpc itself has no known interaction with Colesevelam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Alpha-gpc and Colesevelam Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#157 of 1,452 supplements looked up here in the last 7 days
#2,435 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-gpc reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alpha-gpc and Colesevelam records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Alpha-gpc
What is Alpha-gpc?
- Memory and learning support
- Age-related cognitive decline
- Alzheimer's disease and dementia (under study)
- Athletic and physical performance
- Source of choline
Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence in healthy people is limited. Talk to your pharmacist or doctor before starting it, especially if you take other medicines or have a health condition.
Synthesized compound; also found naturally in soy lecithin and small amounts in foods · Capsules, tablets, powder, liquid
An interaction check asks whether these two react with each other — it does not ask whether Alpha-gpc is a good idea for someone in your situation. Here is what our Alpha-gpc record says about it on its own.
Alpha-gpc: dosing
There is no official, standardized dose of Alpha-GPC for any condition. Doses used in research have varied depending on the purpose and the people studied.The safest approach is to follow the directions on the product label and not exceed them.
From our Alpha-gpc monograph — the full record covers uses, side effects and every documented interaction.
About Colesevelam
What Is Colesevelam Used For?
Brand names: WelChol, Lodalis
Colesevelam is used alongside diet and exercise to reduce high LDL cholesterol (the "bad" cholesterol) in adults with primary hyperlipidemia (high cholesterol). It is also approved to lower LDL cholesterol in boys and girls aged 10–17 who have heterozygous familial hypercholesterolemia (HeFH) — an inherited condition that causes very high cholesterol — when diet and lifestyle changes alone haven't worked.
Colesevelam tablets and oral suspension (Welchol and colesevelam hydrochloride products) are also used to improve blood sugar control in adults with type 2 diabetes, as an add-on to diet and exercise. Colesevelam is not for type 1 diabetes or diabetic ketoacidosis.
Most-Reported Side Effects for Colesevelam
From FAERS, the FDA’s public side-effect reporting system (2,014 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Alpha-gpc
Browse every other medication we’ve checked against Alpha-gpc — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
16 interactions
- Scopolamine ›
- Methscopolamine Bromide ›
- Chlorpheniramine, Methscopolamine, Phenylephrine ›
- Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine ›
- Atropine, Hyoscyamine, Scopolamine, Phenobarbital ›
- Chlorpheniramine, Methscopolamine, Pseudoephedrine ›
- Atropine, Hyoscyamine, Phenobarbital, Scopolamine ›
- Belladonna Alkaloids, Phenobarbital ›
- Atropine, Hyoscyamine, Scopolamine ›
- Barbital, Hyoscyamine, Scopolamine, Passiflora, Valeri ›
- Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian ›
- Chlorpheniramine, Methscopolamine ›
- Chlorpheniramine, Methscopolamine, Phenylpropanolamine ›
- Dextromethorphan, Methscopolamine, Phenylephrine ›
- Methscopolamine, Mivacurium, Phenylephrine ›
- Methscopolamine, Pseudoephedrine ›
No interaction 2,813 drugs checked — show the list
We also checked Alpha-gpc against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Alpha-gpc list.
Alpha-gpc References
The 4 references that drive our Alpha-gpc monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
- Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
- Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
- Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Alpha-gpc and Colesevelam Together: Common Questions
Is it safe to take Alpha-gpc with Colesevelam?
Do Alpha-gpc and Colesevelam have any of the same side effects?
Should I take Alpha-gpc and Colesevelam at the same time of day?
How was the Alpha-gpc and Colesevelam combination checked?
Does Alpha-gpc interact with any other medications?
Does Colesevelam interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.