Dulse Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Dulse interacts with medications. The heart of this page is the interaction list — every drug Dulse is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Dulse is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Dulse against your medication
Add one medicationDulse Drug Interactions: The Bottom Line
From the HelloPharmacist Editorial Team · Updated July 2026Based on the available evidence, the overall risk of a clinically significant Dulse drug interaction appears low for most people. None of the listed interactions are rated major, most are minor, and nearly all rest on theoretical concerns rather than documented problems in people.
The iodine in dulse is the main thing we watch. It could shift thyroid function, which matters most for people taking thyroid hormone or antithyroid drugs, and clinical research has linked dulse to a measurable rise in thyroid stimulating hormone levels. The same iodine concern applies to amiodarone, a heart rhythm drug that already carries a large iodine load. Dulse is also rich in potassium, so pairing it with digoxin or potassium-sparing diuretics could in theory push potassium too high, though this has not been shown in humans.
A long list like this does not mean every combination is harmful. Most entries are predictions based on dulse's natural iodine and potassium content, not on reported harm. In fact, moderate dietary potassium taken with blood pressure medicines has not raised potassium levels in people, so many of these concerns may never play out in real life.
Based on HelloPharmacist’s Dulse interaction data and reviewed under our editorial standards.
Drugs that interact with Dulse
85 medications have a known interaction with Dulse, graded by severity. Select any drug for the full evidence-based detail.
Don’t want to scroll the list? Just ask.
Tell us the medications you take and we’ll check each one against Dulse using our pharmacist-reviewed interaction data.
AI summaries are generated from our Dulse interaction data for education only — always confirm with your pharmacist. How we use AI
No drugs match “”.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Dulse combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The kinds of drugs Dulse affects
Every type of medication (drug category) Dulse is known to interact with. Open any category for the detail — or search your exact drug in the checker above.
Amiodarine (Cordarone)
Theoretically, combining dulse with amiodarone might cause excessively high iodine levels.
Dulse is rich in iodine, and amiodarone contains 37.3% iodine and can increase iodine levels.
Antithyroid Drugs
Theoretically, due to its iodine content, dulse might alter the effects of antithyroid drugs.
Dulse is rich in iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history.
Digoxin (Lanoxin)
Theoretically, dulse might increase the risk of hyperkalemia when taken with digoxin.
Dulse is rich in potassium, and digoxin can increase potassium levels in the blood. This interaction has not been demonstrated in humans.
Thyroid Hormone
Theoretically, due to its iodine content, dulse might alter the effects of thyroid hormone.
Dulse is rich in iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Although dulse has been associated with a statistically significant increase in thyroid stimulating hormone (TSH) levels in clinical research, clinically significant increases have not been documented.
Ace Inhibitors (Aceis)
Theoretically, dulse might increase the risk of hyperkalemia when taken with ACEIs.
Dulse is rich in potassium. ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels. However, using these drugs while consuming dulse in quantities that provide larger amounts of potassium daily might increase the risk of hyperkalemia. Additionally, in vitro research suggests that dulse protein hydrolysates inhibit the activity of ACE. However, these effects have not been demonstrated in humans.
Angiotensin Receptor Blockers (Arbs)
Theoretically, dulse might increase the risk of hyperkalemia when taken with ARBs.
Dulse is rich in potassium. ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels. However, using these drugs while consuming dulse in quantities that provide higher amounts of potassium daily might increase the risk of hyperkalemia. Additionally, in vitro research suggests that dulse protein hydrolysates inhibit the activity of angiotensin converting enzyme (ACE). However, these effects have not been demonstrated in humans.
Potassium-Sparing Diuretics
Theoretically, dulse might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dulse is rich in potassium, and potassium-sparing diuretics can increase potassium levels in the blood. This interaction has not been shown in humans.
Dulse: Uses, Safety & Side Effects
Dulse is a red seaweed eaten as a food in many coastal cultures and is a natural source of iodine, potassium, protein, and antioxidant compounds. As a food it is generally considered safe for most people, but concentrated supplements can deliver large amounts of iodine and potassium, so use caution. Talk to your pharmacist or doctor before using it medicinally, especially if you have thyroid or kidney problems.

- Scientific name
- Palmaria palmata
- Family
- Palmariaceae
- Part used
- Whole edible thallus (the leafy seaweed fronds)
- Common forms
- Dried flakes, whole dried leaf, powder, capsules, and as a food ingredient
- Nutritional supplement (iodine, minerals)
- Source of plant protein
- General wellness
- Anti-inflammatory support
- Thyroid/iodine support
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as a food, but supplements may contain high iodine and potassium and should be used cautiously.
There is insufficient reliable information available about the safety of dulse when used in medicinal amounts during pregnancy or lactation; avoid amo...
Read the full pregnancy detailThere is insufficient reliable information available about the safety of dulse when used in medicinal amounts during pregnancy or lactation; avoid amo...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Dulse (Palmaria palmata) is a red seaweed that grows along the cold, rocky coasts of the northern Atlantic and Pacific oceans, including northern Europe, North America, and parts of Japan. People have harvested and eaten it for centuries, especially in places like Ireland, Iceland, and Canada's Maritime provinces.
It is most often used as a food. Dulse can be eaten dried as a chewy snack, sprinkled as flakes onto soups and salads, or ground into a powder. More recently it has been sold as a dietary supplement in capsule or powder form, often marketed as a natural source of minerals and protein.
How it works
Dulse naturally contains a mix of nutrients and plant compounds. It is a good source of iodine, which the body needs to make thyroid hormones, and it also provides potassium, protein, fiber, and various vitamins and minerals.
Researchers have identified polyphenols and peptides in dulse that, in test-tube and animal studies, appear to act as antioxidants and may influence inflammation and blood pressure. It is important to understand that these are proposed mechanisms based on early laboratory research and may not translate into clear benefits in people.
Does Dulse work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Dulse, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Hypercholesterolemia
It is unclear if oral dulse is beneficial in patients with hypercholesterolemia.
Insufficient Reliable Evidence To Rate Iodine deficiency
Although there has been interest in using oral dulse for the prevention of iodine deficiency, there is insufficient reliable information about the clinical effects of dulse for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Eaten in normal food amounts, dulse is generally considered safe for most healthy people. The main concerns come from its high iodine and potassium content, which can become significant with concentrated supplements or large servings.
People with thyroid conditions (such as overactive or underactive thyroid) should be cautious, because too much iodine can disrupt thyroid function. People with kidney disease or those told to limit potassium should also be careful, since the body may struggle to clear extra potassium. Like other seaweeds, dulse can also absorb heavy metals from the ocean, so product quality matters.
For pregnancy and breastfeeding, food amounts are likely fine, but concentrated supplements should be avoided because their iodine content can be unpredictable and limited safety data exist. When in doubt, choose food over supplements and check with your doctor or pharmacist.
Side effects
Dulse is usually well tolerated as a food. Possible side effects include digestive upset, such as bloating or gas, especially when eaten in large amounts.
Because of its iodine content, excessive intake can affect the thyroid and may cause symptoms related to too much or too little thyroid hormone over time. Very high potassium intake could be a concern for people with kidney problems. Allergic reactions are uncommon but possible. Stop using it and seek medical care if you notice signs of an allergic reaction.
Dosing
There is no established standardized medicinal dose for dulse. As a food it is eaten in small amounts as flakes, snacks, or a recipe ingredient.
If you use a dulse supplement, follow the directions on the product label and do not exceed the recommended amount. Because iodine and potassium content can vary a lot between products, it is wise to check with a pharmacist or doctor before taking it regularly, particularly if you have thyroid or kidney concerns.
Dulse & Pregnancy
Dulse & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 5 references that drive our Dulse monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Allsopp P, Crowe W, Bahar B, et al. The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults. Eur J Nutr PubMed
- McGrath BM, Harmon JP, Bishop G. Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case report. J Med Case Rep. 2010;4:301. PubMed
- Furuta T, Miyabe Y, Yasui H, Kinoshita Y, Kishimura H. Angiotensin I converting enzyme inhibitory peptides derived from phycobiliproteins of dulse Palmaria palmata. Mar Drugs. 2016;14(2):32. PubMed
- Takase T, Nakamura A, Miyoshi H, et al. Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double-blind placebo-controlled trial. Phytother Res. 2020.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Dulse
144 brands in our database make a supplement containing Dulse.
Supplement products with Dulse
575 products in our database contain Dulse. Open any to see its full ingredient list and every drug interaction we check.
Dulse: Common Questions
What is Dulse used for, and does it work?
Does Dulse interact with prescription medications?
How are Dulse interactions rated?
Is it safe to take Dulse with my medications?
Where does this Dulse interaction information come from?
What is Dulse used for?
Is Dulse safe to eat?
Can I take Dulse if I have a thyroid problem?
Is Dulse safe during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Dulse
A rotating sample of real supplements in our database that list Dulse — open any to see its full ingredients and every drug interaction we check.
- Men's One by Bluebonnet
- One for Men by Bluebonnet
- Ultra Juice Green by Natures Plus
- Dulse by Hawaii Pharm
- Candida Balance by Crystal Star
- MaxiONE Iron Free by Bluebonnet
- Greens on the Go Berry by It Works!
- Thyroid Health by New Sun
- Red Marine Algae 375 mg by Solaray
- For Him Fertility Support by Bluebonnet Intimate Essentials
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